{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:37Z","timestamp":1793640757483,"version":"4.5.1"},"reference-count":37,"publisher":null,"issue":"5","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u00a0\u00a0\u00a0\u00a0\u00a0 To evaluate the diagnostic significance of clinical and demographic parameters for predicting a 2-year probability of ventricular tachyarrhythmias (VT) in patients with chronic heart failure and reduced left ventricular ejection fraction (CHFrLVEF).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Material and methods<\/jats:italic>\n                    \u00a0 This single-center, prospective cohort study included 175 patients with CHFrLVEF who were implanted with a cardioverter defibrillator (CD). The endpoint was a CD-detected episode of VT. Patients were followed up for 2 years with visits at 3, 12, and 24 months after CD implantation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    The primary endpoint was observed in 43 (24.4\u200a%) patients at an average of 20.9\u2008months (95\u200a% confidence interval (CI), 20\u201321.9). The 2-year risk of fatal ventricular arrhythmias increased with detection of unstable VT (one-factor analysis, odds ratio (OR), 4.2; 95\u200a% CI, 1.1\u201316.5; \u0440=0.041; multifactor analysis, OR, 6.3; 95\u200a% CI, 1.5\u201326.3; \u0440=0.012) and with ischemic CHFrLVEF origin (one-factor analysis, OR, 2.2; 95\u200a% CI, 1.1\u20134.5; p=0.021; multifactor analysis, OR, 2.5; 95\u200a% CI, 1.2\u20135.1; \u0440=0.018). In the presence of any type of atrial fibrillation (AF) in patients with non-ischemic CHFrLVEF, the probability of VT increased threefold (one-factor analysis, OR, 2.97; 95\u200a% CI, 1.02\u20138.8; \u0440=0.047; multifactor analysis, OR, 3.5; 95\u200a% CI, 1.1\u201310.9; \u0440=0.032).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u00a0\u00a0\u00a0\u00a0\u00a0 The presence of ischemic heart disease and unstable VT paroxysms can be included in the number of important clinical predictors of VT in patients with CHFrLVEF. In patients with non-ischemic CHF, the presence of AF is associated with a high risk of VT.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2021.5.n1480","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T04:22:47Z","timestamp":1623385367000},"page":"32-40","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Predictors of Occurrence of Ventricular Tachyarrhythmias in Patients with Reduced Left Ventricle Ejection Fraction. Results of Single-Center Prospective Study"],"prefix":"10.68900","volume":"61","author":[{"given":"N. N.","family":"Ilov","sequence":"first","affiliation":[{"name":"Astrakhan State Medical University, Astrakhan;\r\nFederal Center for Cardiovascular Surgery, Astrakhan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. V.","family":"Palnikova","sequence":"additional","affiliation":[{"name":"Federal Center for Cardiovascular Surgery, Astrakhan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Stompel","sequence":"additional","affiliation":[{"name":"Federal Center for Cardiovascular Surgery, Astrakhan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0410. A.","family":"Nechepurenko","sequence":"additional","affiliation":[{"name":"Federal Center for Cardiovascular Surgery, Astrakhan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Packer M. What causes sudden death in patients with chronic heart failure and a reduced ejection fraction? European Heart Journal. 2020;41(18):1757\u201363. DOI: 10.1093\/eurheartj\/ehz553","DOI":"10.1093\/eurheartj\/ehz553"},{"key":"ref2","unstructured":"Shlyakhto E.V., Arutyunov G.P., Belenkov Yu.N., Boytsov S.A., Ardashev A.V., Abdullaev A.A. et al. National guidelines for determining the risk and prevention of sudden cardiac death (2nd edition). \u2013M.: Medpraktika-M;2018. - 247 p. ISBN 978-5-98803-397-4"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB et al. 2017 AHA\/ACC\/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2018;138(13):e210\u201371. DOI: 10.1161\/CIR.0000000000000548","DOI":"10.1161\/CIR.0000000000000615"},{"key":"ref4","unstructured":"Revishvili A.Sh., Shlyakhto E.V., Popov S.V., Pokushalov E.A., Shkolnikova M.A., Sulimov V.A. et al. Clinical recommendations for electrophysiological studies, catheter ablation and implantable antiarrhythmic devices. -M.: VNOA;2017. - 702 p. ISBN 978-5-9500922-0-6"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Zaman S, Goldberger JJ, Kovoor P. Sudden Death Risk-Stratification in 2018\u20132019: The Old and the New. Heart, Lung and Circulation. 2019;28(1):57\u201364. DOI: 10.1016\/j.hlc.2018.08.027","DOI":"10.1016\/j.hlc.2018.08.027"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Notaristefano F, Ambrosio G. Defibrillator and non-ischaemic dilated cardiomyopathy: a never ending story. European Heart Journal Supplements. 2019;21(Suppl B):B5\u20136. DOI: 10.1093\/eurheartj\/suz005","DOI":"10.1093\/eurheartj\/suz005"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Waldmann V, Jouven X, Narayanan K, Piot O, Chugh SS, Albert CM et al. Association Between Atrial Fibrillation and Sudden Cardiac Death: Pathophysiological and Epidemiological Insights. Circulation Research. 2020;127(2):301\u20139. DOI: 10.1161\/CIRCRESAHA.120.316756","DOI":"10.1161\/CIRCRESAHA.120.316756"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"El-Sherif N, Boutjdir M, Turitto G. Sudden Cardiac Death in Ischemic Heart Disease: Pathophysiology and Risk Stratification. Cardiac Electrophysiology Clinics. 2017;9(4):681\u201391. DOI: 10.1016\/j.ccep.2017.08.003","DOI":"10.1016\/j.ccep.2017.08.003"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Pietrasik G, Goldenberg I, McNITT S, Moss AJ, Zareba W. Obesity As a Risk Factor for Sustained Ventricular Tachyarrhythmias in MADIT II Patients. Journal of Cardiovascular Electrophysiology. 2007;18(2):181\u20134. DOI: 10.1111\/j.1540-8167.2006.00680.x","DOI":"10.1111\/j.1540-8167.2006.00680.x"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Hensen LCR, Goossens K, Podlesnikar T, Rotmans JI, Jukema JW, Delgado V et al. Left Ventricular Mechanical Dispersion and Global Longitudinal Strain and Ventricular Arrhythmias in Predialysis and Dialysis Patients. Journal of the American Society of Echocardiography. 2018;31(7):777\u201383. DOI: 10.1016\/j.echo.2018.01.010","DOI":"10.1016\/j.echo.2018.01.010"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Koene RJ, Adkisson WO, Benditt DG. Syncope and the risk of sudden cardiac death: Evaluation, management, and prevention. Journal of Arrhythmia. 2017;33(6):533\u201344. DOI: 10.1016\/j.joa.2017.07.005","DOI":"10.1016\/j.joa.2017.07.005"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Clementy N, Bisson A, Challal F, Andre C, Pierre B, Fauchier L et al. Nonsustained Ventricular Tachycardia at the Time of Implantation Predicts Appropriate Therapies on Rapid Ventricular Arrhythmia in Primary Prevention Patients With Nonischemic Cardiomyopathy: Results From the Very-High-Rate Registry. JACC: Clinical Electrophysiology. 2017;3(11):1338\u20139. DOI: 10.1016\/j.jacep.2017.04.016","DOI":"10.1016\/j.jacep.2017.04.016"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Schmitt C, Alt E, Plewan A, Schomig A. Initial experience with implantation of internal cardioverter\/defibrillators under local anaesthesia by electrophysiologists. European Heart Journal. 1996;17(11):1710\u20136. DOI: 10.1093\/oxfordjournals.eurheartj.a014755","DOI":"10.1093\/oxfordjournals.eurheartj.a014755"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Gutierrez A, Ash J, Akdemir B, Alexy T, Cogswell R, Chen J et al. Nonsustained ventricular tachycardia in heart failure with preserved ejection fraction. Pacing and Clinical Electrophysiology. 2020;43(10):1126\u201331. DOI: 10.1111\/pace.14043","DOI":"10.1111\/pace.14043"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Zecchin M, Di Lenarda A, Gregori D, Merlo M, Pivetta A, Vitrella G et al. Are Nonsustained Ventricular Tachycardias Predictive of Major Arrhythmias in Patients with Dilated Cardiomyopathy on Optimal Medical Treatment? Pacing and Clinical Electrophysiology. 2008;31(3):290\u20139. DOI: 10.1111\/j.1540-8159.2008.00988.x","DOI":"10.1111\/j.1540-8159.2008.00988.x"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Hashimoto K, Amino M, Yoshioka K, Kasamaki Y, Kinoshita T, Ikeda T. Combined evaluation of ambulatory\u2010based late potentials and nonsustained ventricular tachycardia to predict arrhythmic events in patients with previous myocardial infarction: A Japanese noninvasive electrocardiographic risk stratification of sudden cardiac death ( JANIES) substudy. Annals of Noninvasive Electrocardiology. 2021;26(1):e12803. DOI: 10.1111\/anec.12803","DOI":"10.1111\/anec.12803"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Hayashi M, Shimizu W, Albert CM. The Spectrum of Epidemiology Underlying Sudden Cardiac Death. Circulation Research. 2015;116(12):1887\u2013906. DOI: 10.1161\/CIRCRESAHA.116.304521","DOI":"10.1161\/CIRCRESAHA.116.304521"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Burke AP, Virmani R. Pathophysiology of Acute Myocardial Infarction. Medical Clinics of North America. 2007;91(4):553\u201372. DOI: 10.1016\/j.mcna.2007.03.005","DOI":"10.1016\/j.mcna.2007.03.005"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Masarone D, Limongelli G, Ammendola E, Verrengia M, Gravino R, Pacileo G. Risk Stratification of Sudden Cardiac Death in Patients with Heart Failure: An update. Journal of Clinical Medicine. 2018;7(11):436. DOI: 10.3390\/jcm7110436","DOI":"10.3390\/jcm7110436"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Halliday BP, Cleland JGF, Goldberger JJ, Prasad SK. Personalizing Risk Stratification for Sudden Death in Dilated Cardiomyopathy: The Past, Present, and Future. Circulation. 2017;136(2):215\u201331. DOI: 10.1161\/CIRCULATIONAHA.116.027134","DOI":"10.1161\/CIRCULATIONAHA.116.027134"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Goldberger JJ, Suba\u010dius H, Patel T, Cunnane R, Kadish AH. Sudden Cardiac Death Risk Stratification in Patients With Nonischemic Dilated Cardiomyopathy. Journal of the American College of Cardiology. 2014;63(18):1879\u201389. DOI: 10.1016\/j.jacc.2013.12.021","DOI":"10.1016\/j.jacc.2013.12.021"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Chao T-F, Liu C-J, Tuan T-C, Chen S-J, Chen T-J, Lip GYH et al. Risk and Prediction of Sudden Cardiac Death and Ventricular Arrhythmias for Patients with Atrial Fibrillation \u2013 A Nationwide Cohort Study. Scientific Reports. 2017;7(1):46445. DOI: 10.1038\/srep46445","DOI":"10.1038\/srep46445"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Gronefeld GC, Mauss O, Li Y-G, Klingenheben T, Hohnloser SH. Association Between Atrial Fibrillation and Appropriate Implantable Cardioverter Defibrillator Therapy: Results from a Prospective Study. Journal of Cardiovascular Electrophysiology. 2000;11(11):1208\u201314. DOI: 10.1046\/j.1540-8167.2000.01208.x","DOI":"10.1046\/j.1540-8167.2000.01208.x"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Denes P, Wu D, Dhingra R, Pietras RJ, Rosen KM. The Effects of Cycle Length on Cardiac Refractory Periods in Man. Circulation. 1974;49(1):32\u201341. DOI: 10.1161\/01.CIR.49.1.32","DOI":"10.1161\/01.CIR.49.1.32"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Denker S, Lehmann M, Mahmud R, Gilbert C, Akhtar M. Facilitation of ventricular tachycardia induction with abrupt changes in ventricular cycle length. The American Journal of Cardiology. 1984;53(4):508\u201315. DOI: 10.1016\/0002-9149(84)90022-5","DOI":"10.1016\/0002-9149(84)90022-5"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Sharykin A.S., Badtieva V.A., Trunina I.I., Osmanov I.M. Myocardial fibrosis \u2013 a new component of heart remodeling in athletes? Cardiovascular Therapy and Prevention. 2019;18(6):126\u201335. DOI: 10.15829\/1728-8800-2019-6-126-135","DOI":"10.15829\/1728-8800-2019-6-126-135"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Centuri\u00f3n OA, Alderete JF, Torales JM, Garc\u00eda LB, Scavenius KE, Mi\u00f1o LM. Myocardial Fibrosis as a Pathway of Prediction of Ventricular Arrhythmias and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy. Critical Pathways in Cardiology. 2019;18(2):89\u201397. DOI: 10.1097\/HPC.0000000000000171","DOI":"10.1097\/HPC.0000000000000171"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Guichard J-B, Nattel S. Atrial Cardiomyopathy: A Useful Notion in Cardiac Disease Management or a Passing Fad? Journal of the American College of Cardiology. 2017;70(6):756\u201365. DOI: 10.1016\/j.jacc.2017.06.033","DOI":"10.1016\/j.jacc.2017.06.033"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"He X, Gao X, Peng L, Wang S, Zhu Y, Ma H et al. Atrial Fibrillation Induces Myocardial Fibrosis Through Angiotensin II Type 1 Receptor\u2013Specific Arkadia-Mediated Downregulation of Smad7. Circulation Research. 2011;108(2):164\u201375. DOI: 10.1161\/CIRCRESAHA.110.234369","DOI":"10.1161\/CIRCRESAHA.110.234369"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Avitall B, Bi J, Mykytsey A, Chicos A. Atrial and ventricular fibrosis induced by atrial fibrillation: Evidence to support early rhythm control. Heart Rhythm. 2008;5(6):839\u201345. DOI: 10.1016\/j.hrthm.2008.02.042","DOI":"10.1016\/j.hrthm.2008.02.042"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Ling L, Kistler PM, Ellims AH, Iles LM, Lee G, Hughes GL et al. Diffuse Ventricular Fibrosis in Atrial Fibrillation: Noninvasive evaluation and relationships with aging and systolic dysfunction. Journal of the American College of Cardiology. 2012;60(23):2402\u20138. DOI: 10.1016\/j.jacc.2012.07.065","DOI":"10.1016\/j.jacc.2012.07.065"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Hirsh BJ, Copeland-Halperin RS, Halperin JL. Fibrotic Atrial Cardiomyopathy, Atrial Fibrillation, and Thromboembolism: Mechanistic links and clinical inferences. Journal of the American College of Cardiology. 2015;65(20):2239\u201351. DOI: 10.1016\/j.jacc.2015.03.557","DOI":"10.1016\/j.jacc.2015.03.557"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Disertori M, Rigoni M, Pace N, Casolo G, Mas\u00e8 M, Gonzini L et al. Myocardial Fibrosis Assessment by LGE Is a Powerful Predictor of Ventricular Tachyarrhythmias in Ischemic and Nonischemic LV Dysfunction: A Meta-Analysis. JACC: Cardiovascular Imaging. 2016;9(9):1046\u201355. DOI: 10.1016\/j.jcmg.2016.01.033","DOI":"10.1016\/j.jcmg.2016.01.033"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Paoletti Perini A, Bartolini S, Pieragnoli P, Ricciardi G, Perrotta L, Valleggi A et al. CHADS2 and CHA2DS2-VASc scores to predict morbidity and mortality in heart failure patients candidates to cardiac resynchronization therapy. Europace. 2014;16(1):71\u201380. DOI: 10.1093\/europace\/eut190","DOI":"10.1093\/europace\/eut190"},{"key":"ref35","unstructured":"Orkun Temizer, Burak A\u00e7ar, \u00c7agri Yayla, Sefa \u00dcnal, Ahmet G\u00f6ktug Ertem, Esra G\u00fcc\u00fck Ipek et al. The Association between CHA2DS2-VASc Score and Mortality in Patients with Heart Failure with Reduced Ejection Fraction. Acta Cardiologica Sinica. 2017;33(4):429\u201335. DOI: 10.6515\/ACS20170221A"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Kuo L, Chao T-F, Liu C-J, Chen S-J, Tuan T-C, Lin Y-J et al. Usefulness of the CHA2DS2-VASc Score to Predict the Risk of Sudden Cardiac Death and Ventricular Arrhythmias in Patients With Atrial Fibrillation. The American Journal of Cardiology. 2018;122(12):2049\u201354. DOI: 10.1016\/j.amjcard.2018.08.056","DOI":"10.1016\/j.amjcard.2018.08.056"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Nof E, Kutyifa V, McNitt S, Goldberger J, Huang D, Aktas MK et al. CHA2DS2\u2010VASc Score and the Risk of Ventricular Tachyarrhythmic Events and Mortality in MADIT\u2010CRT. Journal of the American Heart Association. 2020;9(1):e014353. 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