{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:34Z","timestamp":1793640694226,"version":"4.5.1"},"reference-count":27,"publisher":null,"issue":"3","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>\n                      <jats:bold>Aim\u00a0\u00a0\u00a0<\/jats:bold>\n                      \u00a0\u00a0\n                    <\/jats:italic>\n                    To evaluate the incidence and features of left atrial appendage (LAA) thrombosis in patients with persistent atrial fibrillation (AF) after novel coronavirus infection (COVID-19).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>\n                      <jats:bold>Material and methods\u00a0<\/jats:bold>\n                    <\/jats:italic>\n                    Percutaneous echocardiography (pcEchoCG) was performed for 128 patients with persistent AF prepared for cardioversion, 36 (28.1\u200a%) of whom had had COVID-19. In 3 (8.3\u200a%) patients, the lung lesion area was 50\u201375\u200a%; in 31 (86.1\u200a%) patients, 25\u201350\u200a%; in 1 (2.8\u200a%) patient, less than 25\u200a%. One patient had no lung lesion. Median time from the onset of COVID-19 to the patient enrollment in the study was 76.5 days. At the time of enrollment, the polymerase chain reaction test for SARS-CoV-2 was negative in all patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results<\/jats:italic>\n                    <\/jats:bold>\n                    Patients after COVID-19 and those who had not had COVID-19 were comparable by age (62.5\u00b19.2 and 62.4\u00b19.1 years, respectively; \u0440=0.956), gender (men 52.8 and 59.8\u200a%, respectively; \u0440=0.471), and risk of stroke (score 2.19\u00b11.28 and score 1.95\u00b11.35, respectively; \u0440=0.350). Duration of the last arrhythmia episode was longer for patients after COVID-19 than for the comparison group (76.5 and 45.0 days, respectively; \u0440=0.011). All patients received oral anticoagulants. 55.6\u200a% of COVID-19 patients received rivaroxaban, whereas 62.0% of patients who had not had COVID-19 were treated with apixaban. Median duration of the anticoagulant treatment was longer for COVID-19 patients than for the comparison group (61.5 and 32.0 days; \u0440=0.051). LAA thrombus was detected in 7 (19.4\u200a%) patients after COVID-19 and in 6 (6.5\u200a%) patients of the comparison group (\u0440=0.030). In COVID-19 patients, the thrombus adhered to LAA wall over the entire thrombus length whereas in patients who had not have COVID-19, the thrombus had a free part that formed a sharp angle with LAA walls. In the presence of LAA thrombus, the LAA blood flow velocity was considerably higher for COVID-19 patients than for the comparison group (31.0\u00b18.9 and 18.8\u00b14.9\u2008cm\/sec, respectively; p=0.010). At the follow-up examination performed at 24.0 days on the average, the thrombus was found to be dissolved in 80 and 50% of patients after and without COVID-19, respectively (\u0440=0.343).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>\n                      <jats:bold>Conclusion\u00a0<\/jats:bold>\n                      \u00a0\u00a0\u00a0\u00a0\n                    <\/jats:italic>\n                    In patients with persistent AF after the novel coronavirus infection, LAA thrombosis was detected more frequently than in patients who had never had COVID-19; it was characterized by mural localization and was not associated with a decrease in LAA blood flow velocity.\n                  <\/jats:p>\n                  <jats:p>\u00a0<\/jats:p>","DOI":"10.18087\/cardio.2022.3.n1790","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:50:50Z","timestamp":1649814650000},"page":"21-27","source":"Crossref","is-referenced-by-count":2,"title":["The left atrial appendage thrombosis of in patients with persistent atrial fibrillation after the novel coronavirus infection"],"prefix":"10.68900","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-3791","authenticated-orcid":true,"given":"E. S.","family":"Mazur","sequence":"first","affiliation":[{"name":"Tver State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-434X","authenticated-orcid":true,"given":"V. V.","family":"Mazur","sequence":"additional","affiliation":[{"name":"Tver State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-7366","authenticated-orcid":true,"given":"N. D.","family":"Bazhenov","sequence":"additional","affiliation":[{"name":"Tver State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1397-1327","authenticated-orcid":true,"given":"M. Ye.","family":"Kunitsina","sequence":"additional","affiliation":[{"name":"Tver State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"ref1","unstructured":"Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Temporary guidelines of the Ministry of Health of the Russian Federation. Version 11 of 07.05.2021.  Available at: https:\/\/static-0.minzdrav.gov.ru\/system\/attachments\/attaches\/000\/055\/735\/original\/B\u041c\u0420_COVID-19.pdf.  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