{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:14Z","timestamp":1793640674352,"version":"4.5.1"},"reference-count":13,"publisher":null,"issue":"5","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u00a0 \u00a0To evaluate the prevalence of iron deficiency (ID) in Russian patients with heart failure (HF).\n                    <jats:italic>Material and methods<\/jats:italic>\n                    \u00a0 \u00a0Iron metabolism variables were studied in 498 (198 women, 300 men) patients with HF. Data were evaluated at admission for HF (97\u200a%) or during an outpatient visit (3\u200a%). ID was determined according to the European Society of Cardiology Guidelines.\n                    <jats:italic>Results \u00a0<\/jats:italic>\n                    \u00a083.1\u200a% of patients had ID; only 43.5\u200a% of patients with ID had anemia. Patients with ID were older: 70.0 [63.0;79.0] vs. 66.0 years [57.0;75.2] (p=0.009). The number of patients with ID increased in parallel with the increase in HF functional class (FC). Among patients with ID, fewer people were past or current alcohol users (p=0.002), and a greater number of patients had atrial fibrillation (60.1 vs. 45.2\u200a%, p=0.016). A multiple logistic regression showed that more severe HF (HF FC) was associated with a higher incidence of ID detection, whereas past alcohol use was associated with less pronounced ID. An increase in N-terminal pro-brain natriuretic peptide (NT-proBNP) by 100\u2008pg\/ml was associated with an increased likelihood of ID (odds ratio, 1.006, 95\u200a% confidence interval: 1.002\u20131.011, p=0.0152).\n                    <jats:italic>Conclusion \u00a0<\/jats:italic>\n                    \u00a0The incidence rate of HF patients is high in the Russian Federation (83.1\u200a%). Only 43.5\u200a% of these patients had anemia. The prevalence of ID in the study population increased with increases in HF FC and NT-proBNP.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2022.5.n2083","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T03:42:59Z","timestamp":1655091779000},"page":"4-8","source":"Crossref","is-referenced-by-count":13,"title":["Iron deficiency in Russia heart failure patients. Observational cross-sectional multicenter study"],"prefix":"10.68900","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-2048","authenticated-orcid":true,"given":"V. Yu.","family":"Mareev","sequence":"first","affiliation":[{"name":"Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-6081","authenticated-orcid":true,"given":"Yu. L.","family":"Begrambekova","sequence":"additional","affiliation":[{"name":"Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-7189","authenticated-orcid":true,"given":"Yu. V.","family":"Mareev","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine; Medical Research and Educational Center, Lomonosov Moscow State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-4282","authenticated-orcid":true,"given":"Zh. D.","family":"Kobalava","sequence":"additional","affiliation":[{"name":"People\u2019s Friendship University of Russia; Vinogradov Municipal Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-2393","authenticated-orcid":true,"given":"L. V.","family":"Karapetyan","sequence":"additional","affiliation":[{"name":"People\u2019s Friendship University of Russia; Vinogradov Municipal Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-8606","authenticated-orcid":true,"given":"S. A.","family":"Galochkin","sequence":"additional","affiliation":[{"name":"People\u2019s Friendship University of Russia; Vinogradov Municipal Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-8933","authenticated-orcid":true,"given":"E. R.","family":"Kazakhmedov","sequence":"additional","affiliation":[{"name":"People\u2019s Friendship University of Russia; Vinogradov Municipal Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4308-4764","authenticated-orcid":true,"given":"A. A.","family":"Lapshin","sequence":"additional","affiliation":[{"name":"People\u2019s Friendship University of Russia; Vinogradov Municipal Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-6900","authenticated-orcid":true,"given":"A. A.","family":"Garganeeva","sequence":"additional","affiliation":[{"name":"Research Institute of Cardiology, Tomsk National Research Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-2234","authenticated-orcid":true,"given":"E. A.","family":"Kuzheleva","sequence":"additional","affiliation":[{"name":"Research Institute of Cardiology, Tomsk National Research Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. \u0410.","family":"Efremushkina","sequence":"additional","affiliation":[{"name":"Altai State Medical University; Altai Territory Cardiological Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"Kiseleva","sequence":"additional","affiliation":[{"name":"Altai Territory Cardiological Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4642-3610","authenticated-orcid":true,"given":"O. L.","family":"Barbarash","sequence":"additional","affiliation":[{"name":"Research Institute for Complex Problems of Cardiovascular Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. B.","family":"Pecherina","sequence":"additional","affiliation":[{"name":"Research Institute for Complex Problems of Cardiovascular Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-6197","authenticated-orcid":true,"given":"A. S.","family":"Galyavich","sequence":"additional","affiliation":[{"name":"Kazan State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. M.","family":"Galeeva","sequence":"additional","affiliation":[{"name":"Kazan State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. V.","family":"Baleeva","sequence":"additional","affiliation":[{"name":"Kazan State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-5186","authenticated-orcid":true,"given":"N. A.","family":"Koziolova","sequence":"additional","affiliation":[{"name":"Academician Vagner Perm State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Veklich","sequence":"additional","affiliation":[{"name":"Academician Vagner Perm State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-2976","authenticated-orcid":true,"given":"D. V.","family":"Duplyakov","sequence":"additional","affiliation":[{"name":"Research Institute of Cardiology, Samara State Medical University; Polyakov Samara Regional Clinical Cardiology Dispensary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Maksimova","sequence":"additional","affiliation":[{"name":"Polyakov Samara Regional Clinical Cardiology Dispensary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-742X","authenticated-orcid":true,"given":"S. S.","family":"Yakushin","sequence":"additional","affiliation":[{"name":"Academician Pavlov Ryazan State Medical University; Ryazan Regional Clinical Cardiology Dispensary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Smirnova","sequence":"additional","affiliation":[{"name":"Academician Pavlov Ryazan State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"Sedykh","sequence":"additional","affiliation":[{"name":"Academician Pavlov Ryazan State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-7730","authenticated-orcid":true,"given":"I. I.","family":"Shaposhnik","sequence":"additional","affiliation":[{"name":"South Ural State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Makarova","sequence":"additional","affiliation":[{"name":"South Ural State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Zemlyanukhina","sequence":"additional","affiliation":[{"name":"Chelyabinsk Municipal Clinical Hospital #1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. V.","family":"Skibitsky","sequence":"additional","affiliation":[{"name":"Kuban State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Fendrikova","sequence":"additional","affiliation":[{"name":"Kuban State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Skibitsky","sequence":"additional","affiliation":[{"name":"Kuban State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Spiropulos","sequence":"additional","affiliation":[{"name":"Clinical Hospital for Emergency Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Seredenina","sequence":"additional","affiliation":[{"name":"Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-5612","authenticated-orcid":true,"given":"Ya. A.","family":"Orlova","sequence":"additional","affiliation":[{"name":"Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0048-268X","authenticated-orcid":true,"given":"K. A.","family":"Eruslanova","sequence":"additional","affiliation":[{"name":"Russian Gerintology Research and Clinical Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-5093","authenticated-orcid":true,"given":"Yu. V.","family":"Kotovskaya","sequence":"additional","affiliation":[{"name":"Russian Gerintology Research and Clinical Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-688X","authenticated-orcid":true,"given":"O. N.","family":"Tkacheva","sequence":"additional","affiliation":[{"name":"Russian Gerintology Research and Clinical Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1219-8398","authenticated-orcid":true,"given":"M. A.","family":"Fedin","sequence":"additional","affiliation":[{"name":"Russian Gerintology Research and Clinical Centre; Pirogov Russian National Research Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure. Circulation. 2003;107(2):223\u20135. DOI: 10.1161\/01.CIR.0000052622.51963.FC","DOI":"10.1161\/01.CIR.0000052622.51963.FC"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Mozaffarian D, Nye R, Levy WC. Anemia predicts mortality in severe heart failure. Journal of the American College of Cardiology. 2003;41(11):1933\u20139. DOI: 10.1016\/S0735-1097(03)00425-X","DOI":"10.1016\/S0735-1097(03)00425-X"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Felker GM, Gattis WA, Leimberger JD, Adams KF, Cuffe MS, Gheorghiade M et al. Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. The American Journal of Cardiology. 2003;92(5):625\u20138. DOI: 10.1016\/S0002-9149(03)00740-9","DOI":"10.1016\/S0002-9149(03)00740-9"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Fitzsimons S, Yeo TJ, Ling LH, Sim D, Leong KTG, Yeo PSD et al. Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype. ESC Heart Failure. 2021;8(6):4572\u201383. DOI: 10.1002\/ehf2.13617","DOI":"10.1002\/ehf2.13617"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European Heart Journal. 2016;37(27):2129\u2013200. DOI: 10.1093\/eurheartj\/ehw128","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Tereshchenko S.N., Galyavich A.S., Uskach T.M., Ageev F.T., Arutyunov G.P., Begrambekova Yu.L. et al. 2020 Clinical practice guidelines for Chronic heart failure. Russian Journal of Cardiology. 2020;25(11):311\u201374. DOI: 10.15829\/1560-4071-2020-4083","DOI":"10.15829\/1560-4071-2020-4083"},{"key":"ref7","unstructured":"World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Av. at: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/85839\/WHO_NMH_NHD_MNM_11.1_eng.pdf?sequence=22&isAllowed=y."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Smirnova M.P., Chizhov P.A., Baranov A.A., Ivanova Yu.I., Medvedeva T.V., Pegashova M.A. Iron deficiency associations in patients with chronic heart failure. The Bulletin of Contemporary Clinical Medicine. 2021;14(4):27\u201334. DOI: 10.20969\/VSKM.2021.14(4).27-34","DOI":"10.20969\/VSKM.2021.14(4).27-34"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Rocha BML, Cunha GJL, Menezes Falc\u00e3o LF. The Burden of Iron Deficiency in Heart Failure. Journal of the American College of Cardiology. 2018;71(7):782\u201393. DOI: 10.1016\/j.jacc.2017.12.027","DOI":"10.1016\/j.jacc.2017.12.027"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Klip IjT, Comin-Colet J, Voors AA, Ponikowski P, Enjuanes C, Banasiak W et al. Iron deficiency in chronic heart failure: An international pooled analysis. American Heart Journal. 2013;165(4):575-582.e3. DOI: 10.1016\/j.ahj.2013.01.017","DOI":"10.1016\/j.ahj.2013.01.017"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Okonko DO, Grzeslo A, Witkowski T, Mandal AKJ, Slater RM, Roughton M et al. Effect of Intravenous Iron Sucrose on Exercise Tolerance in Anemic and Nonanemic Patients with Symptomatic Chronic Heart Failure and Iron Deficiency. Journal of the American College of Cardiology. 2008;51(2):103\u201312. DOI: 10.1016\/j.jacc.2007.09.036","DOI":"10.1016\/j.jacc.2007.09.036"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Ponikowski P, van Veldhuisen DJ, Comin-Colet J, Ertl G, Komajda M, Mareev V et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. European Heart Journal. 2015;36(11):657\u201368. DOI: 10.1093\/eurheartj\/ehu385","DOI":"10.1093\/eurheartj\/ehu385"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H et al. Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency. New England Journal of Medicine. 2009;361(25):2436\u201348. DOI: 10.1056\/NEJMoa0908355","DOI":"10.1056\/NEJMoa0908355"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/2083\/1216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:16:48Z","timestamp":1793639808000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/2083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,31]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2022.5.n2083","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,31]]}}}