{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:16Z","timestamp":1793640676498,"version":"4.5.1"},"reference-count":24,"publisher":null,"issue":"7","license":[{"start":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:00:00Z","timestamp":1659225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim\u00a0\u00a0\u00a0\u00a0\u00a0<\/jats:italic>\n                    To study the relationship of the platelet function and plasma homeostasis with the blood flow in the infarct-related artery (IRA) and with the course of acute myocardial infarction (AMI).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Material and methods\u00a0<\/jats:italic>\n                    This study included 93 patients with AMI (75 patients with ST-elevation AMI and 18 patients without ST segment elevation). 63 patients had TIMI 0-1 blood flow in the IRA and 30 patients had TIMI 2\u20133. Rotational thromboelastometry, impedance aggregometry, the endothelium-dependent vasodilation (EDVD) test, and the thrombodynamics test were performed for all patients. The primary clinical endpoint included the totality of in-hospital complications of AMI, and the secondary endpoint included the totality of out-of-hospital complications of AMI. Major bleedings (BARC 3-5) and minor bleedings (BARC 1-2) were evaluated separately.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    Patients with IRA TIMI 0\u20131 flow were characterized by a shorter blood clotting time (BCT), larger thrombus size and density, more intense platelet aggregation induced by arachidonic acid and ADP, and lower values of the EDVD test. It was found that the parameters of platelet aggregation induced by arachidonic acid (AUC Asa) in combination with BCT allowed assessment of the severity of IRA blood flow disorder (sensitivity 76\u200a%, specificity 71\u200a%) in patients with AMI, regardless of the presence of ST segment elevation on the ECG. In addition, the incidence of the primary endpoint was greater in patients with IRA TIMI 0\u20131 flow (41.3% and 16.7%, respectively; p=0.015). In patients with TIMI 2\u20133 flow in the long-term period of the disease, the incidence of minor bleedings was significantly higher (8.5% and 30.4\u200a%, respectively; p=0.045).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion\u00a0\u00a0\u00a0\u00a0\u00a0<\/jats:italic>\n                    Compared to patients with preserved blood flow, patients with AMI and IRA TIMI 0\u20131 flow are characterized by endothelial dysfunction and more intense processes of thrombogenesis and platelet aggregation. It has been shown for the first time that the combination of two simple criteria for assessing hemostasis (AUC Asa; BCT) allows assessment of the degree of IRA blood flow disorder in patients with AMI.\n                  <\/jats:p>\n                  <jats:p>\u00a0<\/jats:p>","DOI":"10.18087\/cardio.2022.7.n2143","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T09:53:02Z","timestamp":1661161982000},"page":"31-37","source":"Crossref","is-referenced-by-count":3,"title":["The state of platelet and plasma hemostasis as a predictor of coronary blood flow in patients with acute myocardial infarction"],"prefix":"10.68900","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-1154","authenticated-orcid":true,"given":"O. A.","family":"Duhin","sequence":"first","affiliation":[{"name":"Evdokimov Moscow State University of Medicine and Dentistry, Moscow;\r\nDavydovsky Municipal Clinical Hospital, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2316-4238","authenticated-orcid":true,"given":"A. I.","family":"Kalinskaya","sequence":"additional","affiliation":[{"name":"Evdokimov Moscow State University of Medicine and Dentistry, Moscow;\r\nDavydovsky Municipal Clinical Hospital, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-704X","authenticated-orcid":true,"given":"G. I.","family":"Rusakovich","sequence":"additional","affiliation":[{"name":"Evdokimov Moscow State University of Medicine and Dentistry, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-132X","authenticated-orcid":true,"given":"A. S.","family":"Anisimova","sequence":"additional","affiliation":[{"name":"Evdokimov Moscow State University of Medicine and Dentistry, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-0776","authenticated-orcid":true,"given":"J. E.","family":"Netylko","sequence":"additional","affiliation":[{"name":"Evdokimov Moscow State University of Medicine and Dentistry, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-2510","authenticated-orcid":true,"given":"P. A.","family":"Polyakov","sequence":"additional","affiliation":[{"name":"Evdokimov Moscow State University of Medicine and Dentistry, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6310-7636","authenticated-orcid":true,"given":"E. Yu.","family":"Vasilieva","sequence":"additional","affiliation":[{"name":"Evdokimov Moscow State University of Medicine and Dentistry, Moscow;\r\nDavydovsky Municipal Clinical Hospital, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-6808","authenticated-orcid":true,"given":"A. V.","family":"Shpektor","sequence":"additional","affiliation":[{"name":"Evdokimov Moscow State University of Medicine and Dentistry, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2022,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Alabas OA, Jernberg T, Pujades-Rodriguez M, Rutherford MJ, West RM, Hall M et al. Statistics on mortality following acute myocardial infarction in 842 897 Europeans. Cardiovascular Research. 2020;116(1):149\u201357. DOI: 10.1093\/cvr\/cvz197","DOI":"10.1093\/cvr\/cvz197"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Widimsky P, Crea F, Binder RK, L\u00fcscher TF. The year in cardiology 2018: acute coronary syndromes. European Heart Journal. 2019;40(3):271\u201382. DOI: 10.1093\/eurheartj\/ehy904","DOI":"10.1093\/eurheartj\/ehy904"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Fefer P, Beigel R, Atar S, Aronson D, Pollak A, Zahger D et al. Outcomes of Patients Presenting With Clinical Indices of Spontaneous Reperfusion in ST-Elevation Acute Coronary Syndrome Undergoing Deferred Angiography. Journal of the American Heart Association. 2017;6(7):e004552. DOI: 10.1161\/JAHA.116.004552","DOI":"10.1161\/JAHA.116.004552"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Stone GW, Cox D, Garcia E, Brodie BR, Morice M-C, Griffin J et al. Normal Flow (TIMI-3) Before Mechanical Reperfusion Therapy Is an Independent Determinant of Survival in Acute Myocardial Infarction: Analysis From the Primary Angioplasty in Myocardial Infarction Trials. Circulation. 2001;104(6):636\u201341. DOI: 10.1161\/ hc3101.093701","DOI":"10.1161\/hc3101.093701"},{"key":"ref5","unstructured":"Urazovskaya I.L., Skrypnik D.V., Vasilieva E.Yu., Shpektor A.V. Influence of the state of the endothelium on the possibility of spontaneous thrombolysis in patients with ST-elevation myocardial infarction. Creative Cardiology. 2008;1:36\u20138."},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Hwang H, Park C, Cho J, Jin E, Sohn I, Kim D et al. Clinical characteristics of occluded culprit arteries and collaterals in patients with non-ST-segment elevation myocardial infarction and impact on clinical outcomes. Experimental and Therapeutic Medicine. 2018;16:3710\u201320. DOI: 10.3892\/etm.2018.6605","DOI":"10.3892\/etm.2018.6605"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA et al. Fourth Universal Definition of Myocardial Infarction (2018). Circulation. 2018;138(20):e618\u201351. DOI: 10.1161\/CIR.0000000000000617","DOI":"10.1161\/CIR.0000000000000617"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Appleby MA, Michaels AD, Chen M, Michael CG. Importance of the TIMI frame count: Implications for future trials. Current Controlled Trials in Cardiovascular Medicine. 2000;1(1):31\u20134. DOI: 10.1186\/CVM-1-1-031","DOI":"10.1186\/CVM-1-1-031"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Korpallov\u00e1 B, Samo\u0161 M, Bolek T, \u0160kor\u0148ov\u00e1 I, Kov\u00e1\u0159 F, Kubisz P et al. Role of Thromboelastography and Rotational Thromboelastometry in the Management of Cardiovascular Diseases. Clinical and Applied Thrombosis\/Hemostasis. 2018;24(8):1199\u2013207. DOI: 10.1177\/1076029618790092","DOI":"10.1177\/1076029618790092"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Balandina AN, Serebriyskiy II, Poletaev AV, Polokhov DM, Gracheva MA, Koltsova EM et al. Thrombodynamics \u2013 A new global hemostasis assay for heparin monitoring in patients under the anticoagulant treatment. PLOS ONE. 2018;13(6):e0199900. DOI: 10.1371\/journal.pone.0199900","DOI":"10.1371\/journal.pone.0199900"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Alley H, Owens CD, Gasper WJ, Grenon SM. Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research. Journal of Visualized Experiments. 2014;92:e52070. DOI: 10.3791\/52070","DOI":"10.3791\/52070"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Lemkes JS, Janssens GN, van Royen N. ST-resolution and spontaneous reperfusion in patients with transient ST-segment elevation myocardial infarction. European Heart Journal. 2019;40(29):2465\u20132465. DOI: 10.1093\/eurheartj\/ehz333","DOI":"10.1093\/eurheartj\/ehz333"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Fefer P, Hod H, Hammerman H, Boyko V, Behar S, Matetzky S. Relation of Clinically Defined Spontaneous Reperfusion to Outcome in ST-Elevation Myocardial Infarction. The American Journal of Cardiology. 2009;103(2):149\u201353. DOI: 10.1016\/j.amjcard.2008.08.050","DOI":"10.1016\/j.amjcard.2008.08.050"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H et al. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet. 2021;397(10285):1637\u201345. DOI: 10.1016\/S0140-6736(21)00676-0","DOI":"10.1016\/S0140-6736(21)00676-0"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Kim JW, Seo HS, Suh SY, Choi CU, Kim EJ, Rha S-W et al. Relationship Between Lipoprotein(a) and Spontaneous Recanalization of Infarct-related Arteries in the Early Phase of Acute Myocardial Infarction. Clinical Cardiology. 2008;31(5):211\u20136. DOI: 10.1002\/clc.20143","DOI":"10.1002\/clc.20143"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Li J, Zhou Y, Zhang Y, Zheng J. Admission homocysteine is an independent predictor of spontaneous reperfusion and early infarct-related artery patency before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction. BMC Cardiovascular Disorders. 2018;18(1):125. DOI: 10.1186\/s12872-018-0868-3","DOI":"10.1186\/s12872-018-0868-3"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Kalinskaya A.I., Savvinova P.P., Vasilieva E.Yu., Shpektor A.V. The specifics of clotting and endogenic fibrinolysis in acute coronary syndrome patients. Russian Journal of Cardiology. 2018;23(9):12\u2013 6. DOI: 10.15829\/1560-4071-2018-9-12-16","DOI":"10.15829\/1560-4071-2018-9-12-16"},{"key":"ref18","unstructured":"Savvinova P.P., Kalinskaya A.I., Manchurov V.N., Anisimov K.V., Vailieva E.Yu., Shpektor A.V. Coronary angiogram and laboratory parameters of blood clot formation and lysis correlation in patients with acute coronary syndrome. Russian Journal of Endovascular Surgery. 2019;6(3):207\u201313. DOI: 10.24183\/2409-4080-2019-6-3-207-213"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Sumaya W, Wallentin L, James SK, Siegbahn A, Gabrysch K, Bertilsson M et al. Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy. European Heart Journal. 2018;39(13):1078\u201385. DOI: 10.1093\/eurheartj\/ehy013","DOI":"10.1093\/eurheartj\/ehy013"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Ma\u0142ek \u0141A, K\u0142opotowski M, \u015apiewak M, Wa\u015b J, Kunicki PK, Ru\u017cy\u0142\u0142o W et al. Patency of infarct-related artery and platelet reactivity in patients with ST-segment elevation myocardial infarction. Cor et Vasa. 2013;55(2):e126\u201330. DOI: 10.1016\/j.crvasa.2012.12.005","DOI":"10.1016\/j.crvasa.2012.12.005"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"B\u00f6rek\u00e7i A, G\u00fcr M, T\u00fcrko\u011flu C, Selek \u015e, Baykan AO, \u015eeker T et al. Oxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction. Clinical and Applied Thrombosis\/Hemostasis. 2016;22(2):171\u20137. DOI: 10.1177\/1076029614546329","DOI":"10.1177\/1076029614546329"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Kalinskaya A, Dukhin O, Lebedeva A, Maryukhnich E, Rusakovich G, Vorobyeva D et al. Circulating Cytokines in Myocardial Infarction Are Associated With Coronary Blood Flow. Frontiers in Immunology. 2022;13:837642. DOI: 10.3389\/fimmu.2022.837642","DOI":"10.3389\/fimmu.2022.837642"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Collet J-P, Thiele H, Barbato E, Barth\u00e9l\u00e9my O, Bauersachs J, Bhatt DL et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. European Heart Journal. 2020;32(23):2999\u20133054. DOI: 10.1093\/eurheartj\/ehaa575","DOI":"10.1093\/eurheartj\/ehaa624"},{"key":"ref24","unstructured":"Sibbing D, Aradi D, Jacobshagen C, Gross L, Trenk D, Geisler T et al. Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial. The Lancet. 2017;390(10104):1747\u201357. DOI: 10.1016\/S0140- 6736(17)32155-4"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/2143\/1252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:16:20Z","timestamp":1793639780000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/2143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,31]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,31]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2022.7.n2143","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,31]]}}}