{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:21Z","timestamp":1793640681934,"version":"4.5.1"},"reference-count":1,"publisher":null,"issue":"8","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u00a0 \u00a0Cardiac involvement in acromegaly is defined as acromegalic cardiomyopathy, an insidious and chronic disease. Previous research on acromegalic cardiomyopathy was largely focused on morphological and functional assessment of the left heart. Since the literature data regarding right heart function in acromegalic patients are limited, we aimed to evaluate the structure and function of the right heart in such patients.\n                    <jats:italic>Material and Method<\/jats:italic>\n                    s \u00a0 \u00a0We included 43 adult participants as the acromegaly group and 42 individuals as the control group. All patients underwent echocardiographic evaluation. The results were compared between acromegaly and control groups and between active and controlled acromegaly groups.\n                    <jats:italic>Results \u00a0<\/jats:italic>\n                    \u00a0The acromegaly group had increased interventricular septum thickness, right ventricular (RV) free wall thickness, right atrium (RA) minor diameter, RV basal and longitudinal diameters, RV end-diastolic and end-systolic areas, E\u200a\/\u200aE\u2019 ratio, isovolumetric relaxation time, and RV ejection time. The E\u200a\/\u200aA ratio and E\u2019 velocity were reduced. GH and IGF-1 were positively correlated with RV longitudinal diameter, indexed RA minor-axis dimension, and indexed RV end-diastolic area. Patients with active acromegaly had increased RV index of myocardial performance (RVIMP) and isovolumetric contraction time and shortened RV ejection time compared to patients in remission. A RVIMP value of 0.435 predicted active acromegaly with a sensitivity and specificity of 0.83 and 0.64, respectively (p=0.002).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u00a0 \u00a0Increases in the size and diameters of the right heart chambers along with RV free wall thickness may be attributed to acromegalic cardiomyopathy. RVIMP, isovolumetric contraction time, and ejection time are parameters that can be used in the evaluation of active acromegaly disease.\n                  <\/jats:p>\n                  <jats:p>\u00a0<\/jats:p>","DOI":"10.18087\/cardio.2022.8.n2147","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T11:39:39Z","timestamp":1662464379000},"page":"52-58","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of right ventricular functions in acromegaly: comparison of active disease with remission"],"prefix":"10.68900","volume":"62","author":[{"given":"Osman","family":"Pirhan","sequence":"first","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd\u00fclcelil Sait","family":"Ertu\u011frul","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cennet","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilay","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Pehlivan","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamide","family":"Piskinpasa","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema Ciftci","family":"Dogansen","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Mert","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref1","unstructured":""}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/2147\/1265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:16:21Z","timestamp":1793639781000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/2147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":1,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,30]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2022.8.n2147","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,30]]}}}