{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:32Z","timestamp":1793640692996,"version":"4.5.1"},"reference-count":12,"publisher":null,"issue":"6","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim\u00a0\u00a0\u00a0\u00a0\u00a0<\/jats:italic>\n                    Evaluating the efficacy and safety of early administration of antirecurrence antiarrhythmic therapy (AAT) following restoration of sinus rhythm (SR) with refralon.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aim\u00a0\u00a0\u00a0\u00a0\u00a0<\/jats:italic>\n                    Evaluating the efficacy and safety of early administration of antirecurrence antiarrhythmic therapy (AAT) following restoration of sinus rhythm (SR) with refralon.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Material and methods\u00a0<\/jats:italic>\n                    The study included 247 patients with atrial fibrillation\/atrial flutter (AF\/AFL) (142 men) who underwent pharmacological cardioversion (PCV) with refralon. A 4-step schedule of drug administration was used (successive intravenous infusions at doses of 5, 5, 10, and 10 \u00b5g\/kg; maximum total dose was 30 \u00b5g\/kg). Patients who recovered SR and had no contraindications were prescribed antirecurrence AAT in the early (\u226424\u2008h; n=101) or delayed (\u226524\u2008h; n=95) period. Lappaconitine hydrobromide, propafenone, and sotalol were administered orally as the antirecurrence therapy. The decision on the time of initiating ATT and the choice of the drug and its dose was taken by the attending physician individually. The safety criteria included a prolonged PQ interval &gt;200\u2008ms; second- or third-degree atrioventricular block; QRS complex duration &gt;120\u2008ms; QT prolongation &gt;500\u2008ms; and heartbeat pauses &gt;3\u2008s. The efficacy criteria included the absence of sustained recurrence of AF\/AFL after initiation of AAT and the duration of hospitalization after PCV. Patients were followed up during the study until they were discharged from the hospital.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    SR was recovered in 229 (92.7 %) patients. In the group of early AAT initiation, a PQ duration &gt;200\u2008ms was observed in 8 (7.9 %) patients, whereas in the group of delayed AAT initiation, in 7 patients (7.4 %; p=1.000). A wide QRS complex &gt;120\u2008ms was recorded in 1 (1.1 %) patient of the delayed AAT initiation group and in none of the patients of the early AAT initiation group (p=0.485). Ventricular arrhythmogenic effects and QT prolongation &gt;500\u2008ms were not detected in any patient. Numbers of early AF recurrence did not differ in the groups of early and delayed AAT initiation: 6 (5.9 %)\n                    <jats:italic>vs<\/jats:italic>\n                    . 5 (5.3 %), respectively (p=1.000). Median duration of hospitalization after PCV was 4 days in the group of early AAT initiation and 5 days in the group of delayed AAT initiation (\u0440=0.009).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion\u00a0\u00a0\u00a0\u00a0\u00a0<\/jats:italic>\n                    Early initiation of the refralon AAT does not increase the risk of drug adverse effects and reduces the duration of stay in the hospital.\n                  <\/jats:p>\n                  <jats:p>\u00a0<\/jats:p>","DOI":"10.18087\/cardio.2023.6.n2276","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T09:43:23Z","timestamp":1689846203000},"page":"21-27","source":"Crossref","is-referenced-by-count":7,"title":["Early initiation of anti-relapse antiarrhythmic therapy in patients with atrial fibrillation and flutter after pharmacological cardioversion with refralon"],"prefix":"10.68900","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9295-6813","authenticated-orcid":true,"given":"D. A.","family":"Gagloeva","sequence":"first","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-1040","authenticated-orcid":true,"given":"Kh. M.","family":"Dzaurova","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-8602","authenticated-orcid":true,"given":"M. A.","family":"Zelberg","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-6784","authenticated-orcid":true,"given":"N. Yu.","family":"Mironov","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-6345","authenticated-orcid":true,"given":"Yu. A.","family":"Yuricheva","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5418-7796","authenticated-orcid":true,"given":"S. F.","family":"Sokolov","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-9974","authenticated-orcid":true,"given":"S. P.","family":"Golitsyn","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Colilla S, Crow A, Petkun W, Singer DE, Simon T, Liu X. Estimates of Current and Future Incidence and Prevalence of Atrial Fibrillation in the U.S. Adult Population. The American Journal of Cardiology. 2013;112(8):1142\u20137. DOI: 10.1016\/j.amjcard.2013.05.063","DOI":"10.1016\/j.amjcard.2013.05.063"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Osmolovskaya Yu.F., Romanova N.V., Zhirov I.V., Tereschenko S.N. Epidemiology and management of heart failure patients with atrial fibrillation. Medical Council. 2016;10:93\u20137. 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