{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:00Z","timestamp":1793640720415,"version":"4.5.1"},"reference-count":13,"publisher":null,"issue":"7","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/cardio.elpub.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u00a0\u00a0\u00a0\u00a0 To evaluate the efficacy and safety of a single sublingual dose of captopril in patients with poor control of arterial hypertension (AH) despite continuous use of long-acting angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). The safety of a single additional dose of a short-acting ACE inhibitor to relieve elevations of blood pressure (BP) in AH patients on ACE inhibitors or ARBs has not been adequately studied.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Material and methods<\/jats:italic>\n                    \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 This was a multicenter, prospective, randomized, double-blind, placebo-controlled pharmacodynamic study. The study included men and women aged 18 to 65 years with an established diagnosis of AH and ineffective treatment, despite regular use of constant doses of antihypertensive drugs for at least 3 weeks before inclusion in the study, who have not missed doses during the previous 3 days. Patients were randomly assigned to a sublingual Capoten 25 mg group (captopril group) or a placebo group at a 1:1 ratio. If the effect was insufficient after 30 min, an additional dose of the study drug (Capoten 25 mg or the respective placebo) was administered in each group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The study included 114 patients (57 patients in each group). At baseline, systolic BP (SBP) and diastolic BP (DBP) before the administration of the study drug did not differ significantly between the groups. At one hour after study drug dosing in the captopril group and the placebo group, mean decrease in SBP was 22.0 \u00b1 10.7 and 11.8 \u00b1 11.9 mm Hg, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). At one hour after captopril dosing, the mean decrease in DBP was 14.1\u00b18.3 and 7.5\u00b15.8 mm Hg, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001). The need for a second dose in the captopril group and the placebo group was 12.3 and 75.4%, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u00a0\u00a0\u00a0\u00a0\u00a0 The study confirmed the efficacy and safety of captopril compared to placebo in patients with a marked increase in BP in the absence of damage to target organs, which supports the validity of using captopril as a first-line drug in such clinical situations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>\u00a0<\/jats:italic>\n                  <\/jats:p>","DOI":"10.18087\/cardio.2025.7.n2984","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T08:09:04Z","timestamp":1754554144000},"page":"28-36","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter Prospective Randomized, Double-Blind, Placebo-Controlled Pharmacodynamic Study of The Additional Antihypertensive Effect of the Drug in Patients With Uncontrolled Arterial Hypertension Against the Background of Taking Renin-Angiotensin-Aldosterone System Blockers"],"prefix":"10.68900","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8505-1848","authenticated-orcid":true,"given":"S. R.","family":"Gilyarevsky","sequence":"first","affiliation":[{"name":"Russian Clinical and Research Center of Gerontology of the Pirogov Russian National Research Medical University, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"Kulibaba","sequence":"additional","affiliation":[{"name":"Vladimir Municipal Hospital #4, Vladimir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"Pobedinskaya","sequence":"additional","affiliation":[{"name":"Polyclinic #2 of the Kuvaevykh Ivanovo Clinical Hospital, Ivanovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. S.","family":"Rodyukova","sequence":"additional","affiliation":[{"name":"Medsi Clinical Hospital in Otradnoe, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Manko","sequence":"additional","affiliation":[{"name":"AO AKRIKHIN, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"Timoshina","sequence":"additional","affiliation":[{"name":"AO AKRIKHIN, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Almazova I.I., Aliyeva A.M., Rakhaev A.M., Komissarova M.S., Reznik E.V., Nikitin I.G. Nikitin. Algorithm for managing hypertensive crises. Therapy. 2020;6(8):113\u201322. DOI: 10.18565\/therapy.2020.8.113-122","DOI":"10.18565\/therapy.2020.8.113-122"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Yan BW, Arun AS, Curtis LH, Kadakia KT, Lin Z, Lu Y et al. JACC Data Report: Cardiovascular Disease Mortality Trends in the United States (1999-2023). Journal of the American College of Cardiology. 2025;85(25):2495\u20138. DOI: 10.1016\/j.jacc.2025.05.018","DOI":"10.1016\/j.jacc.2025.05.018"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Zhou B, Carrillo-Larco RM, Danaei G, Riley LM, Paciorek CJ, Stevens GA et al. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. The Lancet. 2021;398(10304):957\u201380. DOI: 10.1016\/S0140-6736(21)01330-1","DOI":"10.1016\/S0140-6736(21)01330-1"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Fatani N, Dixon DL, Van Tassell BW, Fanikos J, Buckley LF. Systolic Blood Pressure Time in Target Range and Cardiovascular Outcomes in Patients With Hypertension. Journal of the American College of Cardiology. 2021;77(10):1290\u20139. DOI: 10.1016\/j.jacc.2021.01.014","DOI":"10.1016\/j.jacc.2021.01.014"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Wang J, Jiang C, Li S, Wang Z, Wang Y, Lai Y et al. 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DOI: 10.1001\/jamainternmed.2023.1667","DOI":"10.1001\/jamainternmed.2023.1667"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/viewFile\/2984\/1876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:16:45Z","timestamp":1793639805000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/2984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,8,6]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2025.7.n2984","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,6]]}}}