{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T16:40:04Z","timestamp":1746376804676,"version":"3.40.4"},"reference-count":20,"publisher":"APO Society of Specialists in Heart Failure","issue":"7S","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>Aim. To study clinical prognostic value of residual platelet activity in patients with acute coronary syndrome without ST segment elevation. Material and methods. The study included 120 patients with acute coronary syndrome without ST segment elevation (NSTE ACS) with coronary artery stenting. Testing of residual reactivity of platelets in the subjects was carried out after loading doses of\u00a0 aspirin and P2Y12-inhibitors.Patients were divided into two groups comparable in gender and age: with low residual reactivity of platelets (LRR), n=90 and with high residual reactivity of platelets (HRR), n=30. Between the groups a comparative assessment of clinical-laboratory and instrumental indicators, development of a combined end point (ischemic events) and bleeding during follow-up (16 \u00b1 6 months). Results. The group with HRR was initially heavier: patients with angina pectoris of functional class III, atrial fibrillation, myocardial infarction, was a higher risk on the GRACE (202,6\u00b111 vs. 148,6\u00b17, \u0440=0,03),increased levels of Troponin T (70,0 vs. 45,5%, \u0440=0,02), acute occlusion in the coronary arteries (66,6 vs. 42,4%, \u0440=0,02).The combined endpoint was more often reported in patients with HRR (40 vs. 20,7%, \u0440=0,04). Patients with ADP-aggregation of platelets in the range 0\u20131 Om had a greater risk of developing hemorrhagic events (17,1 vs. 2,1%, RR 8,05 CI: 1,1\u201359,9, \u0440=0,01). Conclusion. In patients with NSTE ACSHRR after loading doses of aspirin and P2Y12-inhibitor was associated with the development of repeated atherothrombotic events. Very low LRR was associated with the development of bleeding.<\/jats:p>","DOI":"10.18087\/cardio.2608","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T13:05:06Z","timestamp":1566565506000},"page":"40-46","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and prognostic value of the residual activity of platelets in patients with acute coronary syndrome without st segment elevation"],"prefix":"10.18087","volume":"59","author":[{"given":"O. A.","family":"Stoyko","sequence":"first","affiliation":[{"name":"Regional Clinical Hospital #1 of Tyumen Region"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. V.","family":"Shalaev","sequence":"additional","affiliation":[{"name":"Tyumen State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7442","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V et al. 2014 ESC\/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). European Heart Journal. 2014;35(37):2541\u2013619. 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