{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:21:30Z","timestamp":1740176490614,"version":"3.37.3"},"reference-count":53,"publisher":"APO Society of Specialists in Heart Failure","issue":"9S","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>Aim. The study assesses the effects of therapy based on the use of telmisartan in patients with arterial hypertension and stable angina on\u00a0the clinical and functional indicators of the cardiovascularvascular system. Material and methods. 52 patients with a combination of arterial hypertension (AH) I and II stages and coronary artery disease II with the mean age 63.5 \u00b1 5.4 years (79% males and 21% of\u00a0females) were enrolled in the trial. The duration of AH and CAD were 17.5\u00b13.8 and 12.5\u00b13.1 accordingly. All patients took a daily 80 mg dose of\u00a0telmisartan. The efficacy of treatment was estimated in 3,6 and 12 months. Results. The use of telmisartan in complex treatment of high-risk patients with AH has led to decreasing blood pressure to the target level, increasing exercise tolerance (walking the distance from 315.5 m to 410.2 m in 6 minutes). 12 months of therapy based on telmisartan showed significant decrease in left hy\u2011 pertrophy ventricle (LV myocardial mass index on average by 10.4%), a decrease in the total duration of depression ST segment from 9.6\u00b12.9\u00a0to\u00a02.7\u00b11.5\u00a0mm and a decrease in the depth of depression from 1.5\u00b10.3 mm to 0.3\u00b10.09 mm, with a trend towards decrease in\u00a0the number of episodes of\u00a0ST-segment depression, as well as the absence of a significant change in heart rate. After 12 months of en\u2011 dothelium-dependent vasodilation therapy, the condition of 31 (60%) patients improved, and 18 (35%) patients showed the tendency to improvement. The\u00a0tests with reactive hyperemia conducted after 12 months of treatment revealed decreased linear velocity of blood flow in the brachial artery on\u00a0average by 17%. Conclusion. The use of telmisartan in complex therapy improves the quality of life according to\u00a0the EQ-VAS questionnaire by 25 points after 12 months of therapy, contributes to lowering blood pressure in 96% of patients, reduc\u2011 ing myocardial hypertrophy, endothelial dysfunction and severity of ischemic manifestations (reducing the need for nitroglycerin intake to an average of\u00a00,5 inhalations, as well as a decrease in the ST segment depression of 40% after 12 months of therapy).<\/jats:p>","DOI":"10.18087\/cardio.n356","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T12:04:12Z","timestamp":1571832252000},"page":"42-50","source":"Crossref","is-referenced-by-count":0,"title":["Therapy of patients with the high risk of arterial hypertension with the use of telmisartan"],"prefix":"10.18087","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-4708","authenticated-orcid":true,"given":"A. V.","family":"Nikitin","sequence":"first","affiliation":[{"name":"N.N. Burdenko Voronezh State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9900-556X","authenticated-orcid":true,"given":"L. V.","family":"Vasilieva","sequence":"additional","affiliation":[{"name":"N.N. Burdenko Voronezh State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-2558","authenticated-orcid":true,"given":"E. V.","family":"Gosteva","sequence":"additional","affiliation":[{"name":"N.N. Burdenko Voronezh State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4665-2966","authenticated-orcid":true,"given":"I. A.","family":"Starodubtseva","sequence":"additional","affiliation":[{"name":"N.N. Burdenko Voronezh State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Latisheva","sequence":"additional","affiliation":[{"name":"N.N. Burdenko Voronezh State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7442","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Bliziotis IA, Destounis A, Stergiou GS. Home versus ambulatory and office blood pressure in predicting target organ dam  age in hypertension: a systematic review and meta-analysis. Journal of Hypertension. 2012;30(7):1289\u201399. DOI: 10.1097\/ HJH.0b013e3283531eaf","DOI":"10.1097\/HJH.0b013e3283531eaf"},{"key":"ref2","unstructured":"Ionov M.V., Zvartau N.E., Konradi A.O. First look at new 2018 joint ESH\/ESC Guidelines on diagnosis and management of hypertension. Arterial Hypertension. 2018;24(3):351\u20138. DOI: 10.18705\/1607-419X -2018-243-351-358"},{"key":"ref3","unstructured":"Rogoza A.N., Oszhepkova E.V., Tsagareshvili E.V., Gorieva Sh.B. 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DOI: 10.15829\/1728-8800-2019-1-73-81","DOI":"10.15829\/1728-8800-2019-1-73-81"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Bakris G. Comparison of telmisartan vs. valsartan in the treatment of mild to moderate hypertension using ambulatory blood pressure monitoring. Journal of Clinical Hypertension (Greenwich, Conn.). 2002;4(4 Suppl 1):26\u201331. PMID: 12147926","DOI":"10.1111\/j.1524-6175.2002.01586.x"},{"key":"ref33","unstructured":"Zhusupova A.M. Hemodynamic parameters in patients with arterial hypertension in the treatment of telmisartan. Medicine and Ecology. 2011;1:135\u20138."},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Choi H-J. Blood Pressure Variability and Its Management in Hypertensive Patients. Korean Journal of Family Medicine. 2012;33(6):330\u20135. DOI: 10.4082\/kjfm.2012.33.6.330","DOI":"10.4082\/kjfm.2012.33.6.330"},{"key":"ref35","unstructured":"Mancia G, Facchetti R, Bombelli M, Grassi G, Sega R. LongTerm Risk of Mortality Associated with Selective and Combined Elevation in Office, Home, and Ambulatory Blood Pressure. Hypertension. 2006;47(5):846\u201353. DOI: 10.1161\/01. HYP.0000215363.69793.bb"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Fagard RH, Celis H, Thijs L, Staessen JA, Clement DL, De Buyzere ML et al. Daytime and Nighttime Blood Pressure as Predictors of Death and Cause-Specific Cardiovascular Events in Hypertension. Hypertension. 2008;51(1):55\u201361. DOI: 10.1161\/ HYPERTENSIONAHA.107.100727","DOI":"10.1161\/HYPERTENSIONAHA.107.100727"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Bliziotis IA, Destounis A, Stergiou GS. Home versus ambulatory and office blood pressure in predicting target organ dam  age in hypertension: a systematic review and meta-analysis. Journal of Hypertension. 2012;30(7):1289\u201399. DOI: 10.1097\/ HJH.0b013e3283531eaf","DOI":"10.1097\/HJH.0b013e3283531eaf"},{"key":"ref38","unstructured":"Rogoza A.N., Oszhepkova E.V., Tsagareshvili E.V., Gorieva Sh.B. Modern non-invasive methods of blood pressure measurement for the diagnosis of hypertension and evaluation of the effectiveness of antihypertensive therapy. Manual for doctors. -M.: Medika;2007. \u2013 72 p. ISBN 978-5-98495-010-7"},{"key":"ref39","unstructured":"Leonova M.V. The modern view of endpoints for the evaluation of antihypertensive therapy. Good Clinical Practice. 2002;4:18\u2013 22."},{"key":"ref40","unstructured":"Shubik Yu.V., Baturova M.A., Tregubov A.V. Recommendations for Holter electrocardiogram monitoring: past, present, future. Journal of arrhythmology. 2018;94:57\u201367. DOI: 10.25760\/ VA-2018-94-57-67"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Makarov L.M., Komolyatova V.N., Kupriyanova O.O., Pervova E.V., Ryabykina G.V., Sobolev A.V. et al. National russian guidelines on application of the methods of Holter monitoring in clinical prac  tice. Russian Journal of Cardiology. 2014;19(2):6\u201371.","DOI":"10.15829\/1560-4071-2014-2-6-71"},{"key":"ref42","unstructured":"Ganau A, Devereux RB, Roman MJ, de Simone G, Pickering TG, Saba PS et al. Patterns of left ventricular hypertrophy and geomet  ric remodeling in essential hypertension. Journal of the American College of Cardiology. 1992;19(7):1550\u20138. DOI: 10.1016\/07351097(92)90617-V"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58(6):1072\u201383. DOI: 10.1161\/01.CIR.58.6.1072","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of  Cardiovascular Imaging. Journal of the American Society of Echocardiography: Official Publication of the American Society of Echocardiography. 2016;29(4):277\u2013314. DOI: 10.1016\/j.echo.2016.01.011","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"ATS Statement: Guidelines for the Six-Minute Walk Test. American Journal of Respiratory and Critical Care Medicine. 2002;166(1):111\u20137. DOI: 10.1164\/ajrccm.166.1.at1102","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"ref46","unstructured":"Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet (London, England). 1992;340(8828):1111\u20135. PMID: 1359209"},{"key":"ref47","unstructured":"Zateyshchikov D.A., Minushkina L.O., Kudryashova O.Yu., Barinov  V.G., Tsimbalova T.E., Nosenko E.M. et al. Functional State of Endothelium in Patients with Hypertension and Ischemic Heart Disease. Kardiologiia. 2000;40(6):14\u20137."},{"key":"ref48","unstructured":"Novik A.A., Ionova T.I. Guidelines for the study of quality of life in medicine. -St. Petersburg: Neva; M.:OLMA-Press;2002. \u2013 313 p. ISBN 978-5-7654-2112-3"},{"key":"ref49","unstructured":"Orlov A.I. Applied statistics: a textbook. \u2013 M.: Exam;2006. \u2013 671 p. ISBN 5-472-01122-1"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Pollehn T. The electrocardiographic differential diagnosis of ST seg  ment depression. Emergency Medicine Journal. 2002;19(2):129\u2013 35. DOI: 10.1136\/emj.19.2.129","DOI":"10.1136\/emj.19.2.129"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Kapustnik VA, Shelest BO, Kovalyova YuO, Shelest OM, Brek VV. The use of telmisartan in the treatment of arterial hypertension with obesity. Clinical pharamacy. 2018;22(1):4\u20139. DOI: 10.24959\/ cphj.18.1447","DOI":"10.24959\/cphj.18.1447"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Deneka I.\u0415., Rodionov A.V., Fomin V.V. The use of telmisartan in patients with refractory arterial hypertension and obesity. Cardiovascular Therapy and Prevention. 2019;18(1):73\u201381. DOI: 10.15829\/1728-8800-2019-1-73-81","DOI":"10.15829\/1728-8800-2019-1-73-81"},{"key":"ref53","unstructured":"Zhusupova A.M. Hemodynamic parameters in patients with arterial hypertension in the treatment of telmisartan. Medicine and Ecology. 2011;1:135\u20138."}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/684\/522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T05:50:13Z","timestamp":1576043413000},"score":1,"resource":{"primary":{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/view\/684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":53,"journal-issue":{"issue":"9S","published-online":{"date-parts":[[2019,10,23]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.n356","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"type":"electronic","value":"2412-5660"},{"type":"print","value":"0022-9040"}],"subject":[],"published":{"date-parts":[[2019,10,23]]}}}