{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:03:52Z","timestamp":1746417832006,"version":"3.40.4"},"reference-count":31,"publisher":"APO Society of Specialists in Heart Failure","issue":"9S","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>Background. This study examined clinical, demographic, anthropometric, and inheritance factors that influence individual sensitivity to\u00a0warfarin therapy after heart valve surgery. The clinical significance of the pharmacogenetic approach was assessed using the individual time frame and time spent in the INR therapeutic range. Aims. We determined the clinical outcome of the pharmacogenetic approach at the start of warfarin therapy in patients with prosthetic heart valves. Materials and methods. The study included 915 patients, of\u00a0which 512\u00a0women and 403 men (mean age 56\u00b110 years), living in Western Siberia. Rheumatic heart disease was the main diagnosis that caused the acquired defect. Mechanical prostheses were used in 70% of cases of cardiac surgery. Real-time polymerase chain reaction used for\u00a0molecular genetic testing. Results. The frequencies of the alleles and genotypes of CYP2C9 and VKORC1 in the study population of\u00a0patients with heart valves prosthetic correspond to the distribution in Caucasoid populations. The use of pharmacogenetic testing results at the beginning of warfarin therapy reduced the time required for selecting a therapeutic dose of anticoagulant by\u00a02\u00a0times and increased the duration of stay in the INR therapeutic range by 20.2%. Conclusion. The use of the pharmacogenetic approach at\u00a0the\u00a0begin\u2011 ning of\u00a0warfarin therapy contributes to the effectiveness and safety of anticoagulant therapy in this category of\u00a0patients.<\/jats:p>","DOI":"10.18087\/cardio.n681","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T16:04:12Z","timestamp":1571846652000},"page":"25-30","source":"Crossref","is-referenced-by-count":0,"title":["Efficiency of pharmacogenetic approach to anticoagulant therapy in patients with prosthetic heart valves"],"prefix":"10.18087","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-2637","authenticated-orcid":true,"given":"E. V.","family":"Gorbunova","sequence":"first","affiliation":[{"name":"Federal State Budgetary Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-0889","authenticated-orcid":true,"given":"V. V.","family":"Rozhnev","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3002-2863","authenticated-orcid":true,"given":"A. V.","family":"Ponasenko","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4642-3610","authenticated-orcid":true,"given":"Olga Leonidovna","family":"Barbarash","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7442","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"ref1","unstructured":"Gilyarov M.Yu., Generozov E.V., Magomadova M.U., Moroshkina S.Yu., Pogoda T.V., Kostin P.A. et al. Algorithm of selection of an optimal dose of warfarin considering the polymorphism of cytochrome CYP2C9 gene and subunit 1 of vitamin K epoxide reductase gene. Journal of Arrhythmology. 2011;63:28\u201331."},{"key":"ref2","unstructured":"Gorbunova E.V., Odarenko Yu.N., Mamchur S.E., Kudryavtseva N.G., Salahov R.R. Improving efficiency and safety of anticoagulation therapy in patients with prosthetic heart valves. Complex Issues of  Cardiovascular Diseases. 2015;4:26\u201333."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Park YK, Lee MJ, Kim JH, Lee JS, Park RW, Kim G-M et al. Genetic and Non-Genetic Factors Affecting the Quality of Anticoagulation Control and Vascular Events in Atrial Fibrillation. Journal of Stroke and Cerebrovascular Diseases. 2017;26(6):1383\u201390. DOI: 10.1016\/j.jstrokecerebrovasdis.2017.02.022","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.02.022"},{"key":"ref4","unstructured":"Pop T.R., Chirila D.N., Buzoianu A.D. Pharmacogenetics of oral anticoagulant therapy. Human and Veterinary Medicine. 2013;5(1):9\u201313. 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Therapeutic Archive. 2014;86 (4):64\u201371."},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Biswas M, Bendkhale SR, Deshpande SP, Thaker SJ, Kulkarni DV, Bhatia SJ et al. Association between genetic polymorphisms of CYP2C9 and VKORC1 and safety and efficacy of warfarin: Results of a 5 years audit. Indian Heart Journal. 2018;70(Suppl 3):S13\u20139. DOI: 10.1016\/j.ihj.2018.02.005","DOI":"10.1016\/j.ihj.2018.02.005"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/681\/520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T16:02:58Z","timestamp":1746374578000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":31,"journal-issue":{"issue":"9S","published-online":{"date-parts":[[2019,10,23]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.n681","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"type":"electronic","value":"2412-5660"},{"type":"print","value":"0022-9040"}],"subject":[],"published":{"date-parts":[[2019,10,23]]}}}