{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T21:21:21Z","timestamp":1771968081593,"version":"3.50.1"},"reference-count":11,"publisher":"Institute of Biochemistry","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Accumulation of photosensibilisators - derivatives of E6 chlorines (\"Radachlorine\", \"Photoditazine\", \"Zelevsky's balsam\") in the mucous membrane and selection of most effective sources of emission have been investigated in 30 patients with rhinosinusitis and 10 with tonsillitis. As a source of emission we used light emitting diode (LED) matrix device \"ACT\" (wavelength approximately 405 nm (Sore band)) and a laser device LAHTA-\"MILON\"-ML500-SP (wavelength - 662 nm). Drug accumulation in the mucous membrane and changes of their concentrations after emission were evaluated by changes of fluorescence, measured with a LESA-01-BIOSPEC spectrometer. The percent of fluorescence decrease ranged from 50% to 92.7%. This suggests intensive disintegration of photosensibilisators, and consequently, high therapeutic activity of this method. Effectiveness of this method is also confirmed by clinical results.<\/jats:p>","DOI":"10.18097\/pbmc20125801112","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T08:33:11Z","timestamp":1429864391000},"page":"112-120","source":"Crossref","is-referenced-by-count":7,"title":["Effective photosensibilizator selection for e.n.t.-organ diseases treatment, based on their accumulation in pathologically changed tissues"],"prefix":"10.18097","volume":"58","author":[{"given":"Y.V.","family":"Alexeev","sequence":"first","affiliation":[{"name":"State Research and Clinical Center for Laser Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.V.","family":"Likhacheva","sequence":"additional","affiliation":[{"name":"State Research and Clinical Center for Laser Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.V.","family":"Tereshkin","sequence":"additional","affiliation":[{"name":"State Research and Clinical Center for Laser Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.V.","family":"Ponomarev","sequence":"additional","affiliation":[{"name":"Russian Academy of Medical Science, Institute of Biomedical Chemistry, RAMS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.M.","family":"Mazur","sequence":"additional","affiliation":[{"name":"State Research and Clinical Center for Laser Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2012]]},"reference":[{"key":"ref1","unstructured":"Stranadko E.F., Tolstykh P.I., Koraboev U.N. (1999) Materialy 3-go Vserossijskogo simpoziuma \"Fotodinamicheskaya terapiya\". - M., 83-91."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Juzeniene A., Peng Q., Moan J. (2007) Photochem. Photobiol. Sci., 6(12), 1234-1245.","DOI":"10.1039\/b705461k"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Henderson B., Dougherty T. (1992) Photochem. Photobiol., 55(1), 145-157.","DOI":"10.1111\/j.1751-1097.1992.tb04222.x"},{"key":"ref4","unstructured":"Bondarenko V.M., Konovalova G.N., Nikolaeva E.V., Kuzikov \u0410.N., Likhacheva E.V. (2008) Lazernaya meditsina, 12(2), 26-30."},{"key":"ref5","unstructured":"Gejnits \u0410.V., TSyganova G.I. (2007) Lazernaya meditsina, 11(4), 35."},{"key":"ref6","unstructured":"Markichev N.\u0410., Eliseenko V.I., \u0410lekseev YU.V., \u0410rmichev \u0410.V. (2005) Lazernaya meditsina, 9(2), 16-17."},{"key":"ref7","unstructured":"\u0410lekseev YU.V., Nikolaeva E.V., Makarova YU.B., \u0410rmichev \u0410.V. (2007) Sbornik tezisov VI Mezhdunarodnogo kongressa KOSMETIK international, Moskva, 102-104."},{"key":"ref8","unstructured":"Tsyb \u0410.F., Kaplan M.\u0410., Popuchiev YU.S., Romanenko YU.S. (2007) v kn.: Klinicheskie aspekty fotodinamicheskoj terapii, Moskva, 43-44."},{"key":"ref9","unstructured":"\u0410rmichev \u0410.V., \u0410lekseev YU.V. (2006) Mat. nauchno-prakt. konf. \"Sovremennye dostizheniya lazernoj meditsiny i ikh primenenie v prakticheskom zdravookhranenii\", Moskva, 195."},{"key":"ref10","unstructured":"Isaev V.M., Zenger V.G., \u0410shurov Z.M., Nasedkin \u0410.N., Reshetnikov \u0410.V. (2006) Mat. nauchno-prakt. konf. \"Sovremennye dostizheniya lazernoj meditsiny i ikh primenenie v prakticheskom zdravookhranenii\", Moskva, 144-145."},{"key":"ref11","unstructured":"Likhacheva E.V., \u0410lekseev Yu.V., Murav'ev M.V., Krasnovskij \u0410.\u0410., Ponomarev G.V., Tereshkin D.V., Nikolaeva E.V. (2008) Mat. chetvyortoj mezhdunarodnoj nauchn. konf. BIO-EHMI-2008, Kaluga, 200-201."}],"container-title":["Biomeditsinskaya Khimiya"],"original-title":[],"language":"ru","deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T11:47:46Z","timestamp":1568634466000},"score":1,"resource":{"primary":{"URL":"http:\/\/pbmc.ibmc.msk.ru\/en\/article-en\/PBMC-2012-58-1-112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012]]},"published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.18097\/pbmc20125801112","relation":{},"ISSN":["2310-6905","2310-6972"],"issn-type":[{"value":"2310-6905","type":"electronic"},{"value":"2310-6972","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}