{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:35:27Z","timestamp":1775234127992,"version":"3.50.1"},"reference-count":18,"publisher":"Institute of Biochemistry","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form showed that active form of IgA1 protease exhibited species \u2013 and type-specificity for mouse and human immunoglobulins. Mutant form, which did not exhibit enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C protecting the mice from lethal infection by living virulent culture of heterologous serogroups of meningococcus. Obtained results make it possible to consider IgA1 protease as a perspective preparation at the stages of development of polyvalent vaccine for protection the people from meningococcal infection of various etiology<\/jats:p>","DOI":"10.18097\/pbmc20146004479","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T12:35:43Z","timestamp":1429878943000},"page":"479-486","source":"Crossref","is-referenced-by-count":5,"title":["Protective properties of recombinant igA1 protease from meningococcus"],"prefix":"10.18097","volume":"60","author":[{"given":"O.V.","family":"Kotel\u2019nikova","sequence":"first","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Alliluev","sequence":"additional","affiliation":[{"name":"Medical Faculty, Russian University of Peoples\u2019 Friendship"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.Yu.","family":"Drozhzhina","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.S.","family":"Koroleva","sequence":"additional","affiliation":[{"name":"Municipal infectious deceases hospital \u21162, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.","family":"Sitnikova","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Zinchenko","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.","family":"Gordeeva","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.D.","family":"Melikhova","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.","family":"Nokel","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.S.","family":"Zhigis","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.S.","family":"Zueva","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.A.","family":"Razgulyaeva","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.V.","family":"Serova","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.Yu.","family":"Yagudaeva","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.D.","family":"Rumsh","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2014]]},"reference":[{"key":"ref1","unstructured":"Platonov A.E., Kharit S.M., Platonova O.V. (2009) Epidemiologiya i Vaktsinoprofilaktika, 48(5), 32-45."},{"key":"ref2","unstructured":"Frasch C.E. (1995) Meningococcal vaccines, 7, 245-283."},{"key":"ref3","unstructured":"Donnelly J.J., Deck R.R., Liu M.A. (1990) J. Immunol., 145, 3071-3079."},{"key":"ref4","unstructured":"Sierra G.V.G., Campa H.C., Varacel N.M., Garcia I.L., Izquierdo P.L., Sotolongo P.F., Casanueva G.V., Rico C.O., Rodriguez C.R., Terry M.H. (1991) NIPH Ann., 14, 195\u2013210."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Mulks M.H., Plaut A.G. (1978) N. Engl. J. Med., 299, 973-976.","DOI":"10.1056\/NEJM197811022991802"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Plaut A.G. (1983) Annu. Rev. Microbiol., 37, 603-622.","DOI":"10.1146\/annurev.mi.37.100183.003131"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"McNabb P.C., Tomasi T.B. (1981) Annu. Rev. Microbiol., 35, 477-496.","DOI":"10.1146\/annurev.mi.35.100181.002401"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Mistry D., Stockley R.A. (2006) Int. J. Biochem. Cell. Biol.,38, 1244-1248.","DOI":"10.1016\/j.biocel.2005.10.005"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Kazeeva T.N., Shevelyova A.B. (2007) Biokhimiya, 72, 603-614.","DOI":"10.1134\/S0006297907050045"},{"key":"ref10","unstructured":"Serova O.V., Melnikov E.E., Zinchenko A.A., Kotelnikova O.V., Alliluev A.P., Bichucher A.M., Gordeeva E.A., Zhigis L.S., Zueva V.S., Kozlov L.V., Melikhova T.D., Nokel E.A., Yagudaeva E.Yu., Rumsh L.D. (2012) Biofarmatsevticheskij zhurnal, 3(6), 42-47."},{"key":"ref11","unstructured":"Yagudaeva E.Yu., Alliluev A.P., Gordeeva E.A., Zhigis L.S., Zinchenko A.A., Zueva V.S., Kozlov L.V.,.Kotelnikova O.V, Melikhova T.D., Nokel E.A., Razgulyaeva O.A., Serova O.V., Sitnikova E.A., Rumsh L.D. (2012) Materialy XX mezhdunarodnoj konferentsii Novye informatsionnye tekhnologii v meditsine, farmakologii, biologii, i ekologii, Yalta-Gurzuf, s. 101-102."},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Gregory J.L., Rundegren J., Arnold R.R. (1987) J. Immunol. Meth., 99,101-106.","DOI":"10.1016\/0022-1759(87)90037-8"},{"key":"ref13","unstructured":"Kozlov L.V., Romanov S.V., Dyakov V.L., Surovtsev V.I., Tejmurazov M.G. Patent RF \u201cSposob i nabor dlya immunofermentnogo opredeleniya aktivnosti i ingibirovaniya IgA1-proteazy\u201d \u21162310853. Bull. \u2116 32. 20.11.2007."},{"key":"ref14","unstructured":"Yagudaeva E.Yu., Zhigis L.S., Zueva V.S., Melnikov E.E., Zubov V.P., Kozlov L.V., Bichucher A.M., Kotelnikova O.V., Alliluev A.P., Rumsh L.D. (2010) Bioorgan. khimiya, 36, 96-105."},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Laemmli U.K. (1970) Nature, 227, 680\u2013685.","DOI":"10.1038\/227680a0"},{"key":"ref16","unstructured":"Kotelnikova O.V., Chibiskova O.V., Nesmeyanov V.A., Alliluev A.P., Volpina O.M., Koroev D.O., Zhmak M.N., Titova M.A., Ivanov V.T. (2005) Bull. exper. biol. med., \u21165, 553-556."},{"key":"ref17","unstructured":"Alliluev A.P., Kotelnikova O.V., Kuvakina V.I., Bobyleva G.V., Gofman I.L., Kazmina Yu.G. (1995) Zh. Mikrobiol., Epidemiol., Immunol., 4, 67-71."},{"key":"ref18","unstructured":"Yagudaeva E.Yu., Zhigis L.S., Zueva V.S., Melnikov E.E., Zubov V.P., Kozlov L.V., Bichucher A.M., Kotelnikova O.V., Alliluev A.P., Rumsh L.D. (2010) Bioorgan. khimiya, 36, 96-105."}],"container-title":["Biomeditsinskaya Khimiya"],"original-title":[],"language":"ru","deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T15:50:57Z","timestamp":1568649057000},"score":1,"resource":{"primary":{"URL":"http:\/\/pbmc.ibmc.msk.ru\/en\/article-en\/PBMC-2014-60-4-479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014]]},"published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.18097\/pbmc20146004479","relation":{},"ISSN":["2310-6905","2310-6972"],"issn-type":[{"value":"2310-6905","type":"electronic"},{"value":"2310-6972","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}