{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T22:38:47Z","timestamp":1648679927595},"reference-count":25,"publisher":"Institute of Biochemistry","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Ability of fractions of cobra\u2019s (Naja oxiana Eichwald) and copperhead snake\u2019s (Agkistrodon halys halys) venoms to hydrolyze fibrinogen\/fibrin was studied. In cobra\u2019s snake a component with molecular mass of nearly 60 kDa was found to hydrolyze a-chain of fibrinogen but failed to hydrolyze casein\/azocasein and fibrin. A fibrinogen-specific metalloproteinase, the enzyme was inhibited by EDTA. Cobra\u2019s venom reduced the mass of donor\u2019s fresh blood clots. The copperhead snake\u2019s venom and the fractions obtained by gel-filtration (HW-50) and ion exchange chromatography (DEAE-650) were found to hydrolyze casein\/azocasein, a- and b-chains of fibrinogen\/fibrin and donor\u2019s blood clots. The results from the study of the venom and proteolytically active fractions are the evidence for a thrombolytic potential in a copperhead snake\u2019s venom.<\/jats:p>","DOI":"10.18097\/pbmc20166203259","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T07:20:14Z","timestamp":1467271214000},"page":"259-264","source":"Crossref","is-referenced-by-count":0,"title":["Fibrinogen\/fibrin-specific enzymes from copperhead (Agkistrodon halys halys) and cobra (Naja oxiana eichwald) snake venoms"],"prefix":"10.18097","volume":"62","author":[{"given":"E.S.","family":"Yunusova","sequence":"first","affiliation":[{"name":"Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent, Republic of Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.S.","family":"Sadykov","sequence":"additional","affiliation":[{"name":"Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent, Republic of Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.M.","family":"Sultanalieva","sequence":"additional","affiliation":[{"name":"Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent, Republic of Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.V.","family":"Shkinev","sequence":"additional","affiliation":[{"name":"Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent, Republic of Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2016]]},"reference":[{"key":"ref1","unstructured":"Drozd N.N., Miftakhova N.T., Savchik E.Yu., Kalinina T.B., Makarov V.\u0410., Imbs T.I., Zvyagintseva T.N., Kuznetsova T.\u0410., Besednova N.N. 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