{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T15:57:08Z","timestamp":1648915028335},"reference-count":23,"publisher":"Institute of Biochemistry","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Interstitial collagenase (MMP-1) belongs to the family of matrix metalloproteinases (MMP), which play  a key role in generalization processes of invasion and metastasis, which determine the degree of tumor malignancy.  MMP-1 refers to secreted, inducible MMP, the expression of which in normal tissues is not defined. Induction  of expression of MMP in CSS in the tumor occurs under the action of oncogenes of HPV, and in areas adjacent  to the tumor normal tissue under the action of the inductor expression of MMP \u2013 EMMPRIN (CD147), which  expressively on the surface of tumor cells. The aim of this study is to determine the possibility of expression ofMMP-1  and its regulators (tissue inhibitors TIMP-1 and activator - plasminogen activator \u2013 ADF) in morphologically normal  body of the uterus during CSS. The study was carried out using on a tissue \u201ctape\u201d \u2013 postoperative specimens  of the uterus when the diagnosis of CSS. All of the samples was expressed HPV16 gene E7. It was shown that:  1. The increase of MMP-1 expression, low expression (or lack thereof) of its inhibitors TIMP-1 and a very clear  expression of the activator take place in the tumor when CSS that lead to increased activity of MMP-1, and aims  to increase the destructive (invasive) potential of the tumor. 2. In morphologically normal tissue of the uterus  during CSS the expression of MMP-1 can occur from the vaginal wall to the bottom of the uterine cavity, but at a much  lower level than in the tumor. 3. These data indicate the possibility of development of a destructive process  in morphologically normalnyh body tissues of the uterus during CSS, important for understanding the mechanism  of tumor progression, and suggest participation in the process of expression of MMP-1 signaling by the type  of epithelial-mesenchymal interaction .<\/jats:p>","DOI":"10.18097\/pbmc20176306513","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T16:53:32Z","timestamp":1513616012000},"page":"513-519","source":"Crossref","is-referenced-by-count":3,"title":["Interstitial collagenase and their endogenous regulators in squamous cell cervical carcinoma"],"prefix":"10.18097","volume":"63","author":[{"given":"O.S.","family":"Timoshenko","sequence":"first","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.A.","family":"Gureeva","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.V.","family":"Kugaevskaya","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.E.","family":"Zavalishina","sequence":"additional","affiliation":[{"name":"Medical Academy of Postgraduate Education , Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.I.","family":"Solovyeva","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2017]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Visse R., Nagase H. 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