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In this study, we have identified different allelic variants of the mtDNA oriB site  in MS patients (n=106) and healthy individuals (n=71) using capillary sequencing, and determined the amount  of mtDNA copy blood leukocytes by droplet digital polymerase chain reaction (ddPCR). The continuous polycytosine  tract was significantly more common in MS patients, and such a link was particularly strong in MS patients  with type 2 diabetes (p&lt;0.01). No significant correlation has been found between mtDNA copy number  and the oriB site variants, but in general there is a tendency to decreased mtDNA copy number in MS patients.<\/jats:p>","DOI":"10.18097\/pbmc20176306533","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T16:53:32Z","timestamp":1513616012000},"page":"533-538","source":"Crossref","is-referenced-by-count":3,"title":["The association of the mitochondrial DNA oriB variants with metabolic syndrome"],"prefix":"10.18097","volume":"63","author":[{"given":"D.A.","family":"Skuratovskaia","sequence":"first","affiliation":[{"name":"Immanuel Kant Baltic Federal University, Kaliningrad, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.K.","family":"Sofronova","sequence":"additional","affiliation":[{"name":"Immanuel Kant Baltic Federal University, Kaliningrad, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Zatolokin","sequence":"additional","affiliation":[{"name":"Kaliningrad Region Hospital, Kaliningrad, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Vasilenko","sequence":"additional","affiliation":[{"name":"Immanuel Kant Baltic Federal University, Kaliningrad, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.S.","family":"Litvinova","sequence":"additional","affiliation":[{"name":"Immanuel Kant Baltic Federal University, Kaliningrad, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.O.","family":"Mazunin","sequence":"additional","affiliation":[{"name":"Immanuel Kant Baltic Federal University, Kaliningrad, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2017]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Sorriento D., Pascale A.V., Finelli R., Carillo A.L., Annunziata R., Trimarco B., Iaccarino G. 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