{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T21:01:24Z","timestamp":1761253284446},"reference-count":28,"publisher":"Institute of Biochemistry","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Synthesis of lipoilcarnosine (LipC) \u2013 a conjugated molecule based on two natural antioxidants, carnosine and  a-lipoic acid, is described. Its physico-chemical, antioxidant properties and biological activity are characterized.  According to reversed-phase HPLC with a UV detector, purity of the final product was 89.3%. The individuality  of the obtained sodium salt of LipC was confirmed by tandem HPLC-mass spectrometry. High resistance of LipC  to hydrolysis with serum carnosinase was demonstrated. The antioxidant activity of LipC measured by reaction  with the formation of thiobarbituric acid reacting substances and kinetic parameters of iron-induced chemiluminescence  was higher than that of carnosine and lipoic acid. LipC did not affect viability of SH-SY5Y human neuroblastoma  culture cells, differentiated towards the dopaminergic type, at concentrations not exceeding 5 mM. At the concentration  range of 0.1-0.25 mM LipC protected neuronal cells against 1-methyl-4-phenylpyridinium (MPP + )-induced toxicity.<\/jats:p>","DOI":"10.18097\/pbmc20186403268","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T10:59:44Z","timestamp":1530529184000},"page":"268-275","source":"Crossref","is-referenced-by-count":5,"title":["Lipoilcarnosine: synthesis, study of physico-chemical and antioxidant properties, biological activity"],"prefix":"10.18097","volume":"64","author":[{"given":"S.L.","family":"Stvolinsky","sequence":"first","affiliation":[{"name":"Research Center of Neurology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.A.","family":"Antonova","sequence":"additional","affiliation":[{"name":"Moscow Technological University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.I.","family":"Kulikova","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, Moscow, Russia; Peoples' Friendship University of Russia, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.V.","family":"Lopachev","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.","family":"Abaimov","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Al-Baidani","sequence":"additional","affiliation":[{"name":"Moscow Technological University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.M.","family":"Lopacheva","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, Moscow, Russia; Lomonosov Moscow State University, International Biotechnological Center, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.N.","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Kaplun","sequence":"additional","affiliation":[{"name":"Moscow Technological University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.M.","family":"Sorokoumova","sequence":"additional","affiliation":[{"name":"Moscow Technological University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2018]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Halliwell B., Rafter J., Jenner A. 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