{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T12:44:06Z","timestamp":1648903446726},"reference-count":25,"publisher":"Institute of Biochemistry","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>The aim of the study was to assess the prooxidant-antioxidant balance depending on endothelial nitric oxide  synthase G894T polymorphism. The frequency distribution of alleles and genotypes of G894T polymorphism,  nitrite concentration, hydrogen sulphide, lipid peroxidation products (diene conjugates, malonic dialdehyde),  antioxidants (reduced glutathione, catalase, ceruloplasmin, retinol) were determined in venous blood of healthy males.  The incidence of the GG genotype was 49.1%, GT \u2013 44.2%, TT \u2013 6.7%. The level of malonic dialdehyde  in erythrocytes with the GG genotype is 16.8% lower than in the genotype GT. The concentration of hydrogen sulphide  in the blood with the GG genotype was 27.5 [18,2; 32,5] mM, GT \u2013 28.6 [22.9; 33.8] mM, TT \u2013 36.3 [33.8; 42.5] mM.  The content of total nitrites in plasma with the GG genotype was 10.4 [9,0; 12,5] mM, GT \u2013 10.4 [8.9; 11.8] mM,  TT \u2013 9.4 [8.8; 9.8] mM. The genotype GG causes a lower level of malonic dialdehyde in comparison with  the heterozygous genotype. The G894T polymorphism allele T is associated with a low content of total nitrites  in the plasma and a high concentration of hydrogen sulfide. The data obtained suggest that if the oxygen supply  of the organism is impaired, the endothelial nitric oxide synthase G894T polymorphism may be important  for the oxidative stress development.<\/jats:p>","DOI":"10.18097\/pbmc20186404349","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T07:29:23Z","timestamp":1535009363000},"page":"349-353","source":"Crossref","is-referenced-by-count":0,"title":["Prooxidant-antioxidant balance depending on endothelial nitric oxide synthase G894T polymorphism"],"prefix":"10.18097","volume":"64","author":[{"given":"V.V.","family":"Zinchuk","sequence":"first","affiliation":[{"name":"Grodno State Medical University, Grodno, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.D.","family":"Zhadko","sequence":"additional","affiliation":[{"name":"Grodno State Medical University, Grodno, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.E.","family":"Gulyai","sequence":"additional","affiliation":[{"name":"Grodno State Medical University, Grodno, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2018]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Gudkov L.L., Shumaev K.B., Kalennikova E.I., Vanin A.F., Ruuge E.K. 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