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CLEC-2 and  podoplanin are involved in the processes of embryonic development (blood-lymph vessel separation and angiogenesis),  maintaining of vascular integrity of small vessels during inflammation and prevention of blood-lymphatic mixing  in high endothelial venules. However, CLEC-2 and podoplanin are contributing to tumor methastasis progression,  Salmonella sepsis, deep-vein thrombosis. CLEC-2 signalling cascade includes tyrosine-kinases (Syk, SFK, Btk)  as well as adapter LAT and phospholipase Cg2, which induces calcium signalling. CLEC-2, podoplanin and proteins,  participating in CLEC-2 signalling cascade, are perspective targets for antithrombotic therapy.<\/jats:p>","DOI":"10.18097\/pbmc20186405387","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T07:00:08Z","timestamp":1540969208000},"page":"387-396","source":"Crossref","is-referenced-by-count":3,"title":["CLEC-2 induced signalling in blood platelets"],"prefix":"10.18097","volume":"64","author":[{"given":"A.A.","family":"Martyanov","sequence":"first","affiliation":[{"name":"Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia; Center for Theoretical Problems of Physicochemical Pharmacology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.N.","family":"Kaneva","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia; Rogachev National Scientific and Practical Centre of Pediatric Hematology, Oncology and Immunology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Panteleev","sequence":"additional","affiliation":[{"name":"Center for Theoretical Problems of Physicochemical Pharmacology, Moscow, Russia; Rogachev National Scientific and Practical Centre of Pediatric Hematology, Oncology and Immunology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.N.","family":"Sveshnikova","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia; Center for Theoretical Problems of Physicochemical Pharmacology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7443","published-online":{"date-parts":[[2018]]},"reference":[{"key":"ref1","unstructured":"Gajton A., Kholl Dzh. 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