{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:49:24Z","timestamp":1759042164535},"reference-count":22,"publisher":"Institute of Biochemistry","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>To clarify the role of the infectious factor in the development of premature birth (PB) in women in serum,  the content of TLR-4, the p65 subunit of the nuclear factor NF-kB, the cytokine TNF-a and the activity of PLA2  (phospholipase A2) were determinated by the enzyme immunoassay was studied. The profile of bioregulators in women  with premature births was characterized by a high content of TLR-4, TNF-a and an increase in PLA2 activity  and a decrease in the activity of the p65 subunit of NF-kB. 89 women aged 20-39 years were examined at 34-40 weeks  gestation. They were divided into two groups: 42 women with preterm birth at 34-36.6 weeks, the control group  is represented by 47 patients. The risk factors for PB are the presence of PB in history, endocervicitis, colpitis,  dysbiosis, diseases of the urinary system (chronic pyelonephritis, chronic cystitis), aggravated obstetric and  gynecological history (the threat of abortion during gestation, moderate preeclampsia, anemia of the pregnant woman).  The obtained data of the studied bioregulators testify to the role of the infectious inflammatory process  in the development of PB, which is evidenced by the high level of TLR-4, a component of innate immunity leading  to the activation of the TLR-4 signaling pathway, which increases the activity of PLA2-factor of premature contractile  activity of the uterus.<\/jats:p>","DOI":"10.18097\/pbmc20186405439","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T11:00:08Z","timestamp":1540983608000},"page":"439-443","source":"Crossref","is-referenced-by-count":1,"title":["The role of modification of innate immunity in development of premature labore"],"prefix":"10.18097","volume":"64","author":[{"given":"N.A.","family":"Drukker","sequence":"first","affiliation":[{"name":"Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.A.","family":"Durnitsyna","sequence":"additional","affiliation":[{"name":"Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Nikashina","sequence":"additional","affiliation":[{"name":"Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2018]]},"reference":[{"key":"ref1","unstructured":"Saveleva G.M., Shalina R.I., Kurtser M.A., Shtabnitskij A.M., Kurtenok N.V., Konovalova O.V. 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