{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T19:20:04Z","timestamp":1688584804991},"reference-count":27,"publisher":"Institute of Biochemistry","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Congenital pseudarthrosis of tibia is a genetic, systemic pathology with impaired bone remodeling  and unknown pathogenetic mechanisms. Orthopaedic treatment of the disease can fail in some cases. The process  of bone remodeling is known to occur under control of local and systemic growth factors, and we sought to explore  several osteotropic growth factors, markers of osteogenesis and biologically active molecules in the blood serum  of patients with congenital pseudarthrosis of tibia. The study included 12 patients with congenital pseudarthrosis of tibia  and anatomical shortening of 2.5\u00b11.1 cm. The' age of patients ranged from 7 years to 18 years. Blood serum was used  for enzyme immunoassay analysis. The own blood serum levels of 103 conditionally healthy individuals (of mean age  of 13.0\u00b10.27 years) were considered as the norm. Greater changes in the concentration were detected among  vascular endothelial and transforming growth factors. The patients showed imbalance in serum TGF, low reparative  potential of bone tissue due to osteoclast activation prevailing over differentiation of osteoblasts, progenitor and  mesenchymal cells. Dynamics in serum concentration of IGF at the time of frame removal indicated to terminating  osteoblast activation and collagen synthesis and concomitant active bone restructuring.<\/jats:p>","DOI":"10.18097\/pbmc20186406525","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T13:55:26Z","timestamp":1546005326000},"page":"525-533","source":"Crossref","is-referenced-by-count":1,"title":["Concentration of several osteotropic growth factors, markers of osteogenesis and biologically active molecules in the blood serum of patients with congenital pseudarthrosis of tibia during orthopaedic treatment with combined technologies"],"prefix":"10.18097","volume":"64","author":[{"given":"E.P.","family":"Vykhovanets","sequence":"first","affiliation":[{"name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.N.","family":"Luneva","sequence":"additional","affiliation":[{"name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.V.","family":"Nakoskina","sequence":"additional","affiliation":[{"name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.Yu.","family":"Borzunov","sequence":"additional","affiliation":[{"name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia; Tyumen State Medical University, Tyumen, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.S.","family":"Mokhovikov","sequence":"additional","affiliation":[{"name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2018]]},"reference":[{"key":"ref1","unstructured":"Kutikov S.A., Lettreuch A.R., Saighi-Bouaounina A., Borzunov D.Yu., Dyachkova G.V. 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