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Knowledge about the patient's genetic susceptibility to keratoconus would allow correcting the tactics of treatment of refractive anomalies and avoiding serious side effects. The studies of causal mutations indicate the genetic heterogeneity of keratoconus, which complicates the development of a diagnostic panel. Selection of candidate variants from the currently known ones based on clear criteria may be one of the approaches for diagnostic markers search. In this review, we have analyzed articles on keratoconus markers in order to form a list of candidate variants for genotyping in the Russian population. The selection criteria took into account the complexes of symptoms in which a marker was found, populations in which a particular marker was investigated, the presence and results of replication studies. The analysis included markers in VSX1, SOD1, ZEB1, LOX, CAST, DOCK9, TGFBI, HGF, MAP3K19, KCND3, COL4A3, COL4A4, COL5A1, FNDC3B, FOXO1, BANP-ZNF469, MPDZ-NF1B, WNT10A genes. Based on the results of the analysis, the following candidate variants were selected for genotyping in the Russian population of patients with keratoconus: rs1536482 and rs7044529 in the COL5A1 gene, rs5745752 and rs2286194 in the HGF gene, rs4954218 in the MAP3K19 gene, rs4839200 near the KCND3 gene, rs2721051 near the FOXO1 gene, rs1324183 between the MPDZ and the NF1B genes, and rs121908120 in the WNT10A gene.<\/jats:p>","DOI":"10.18097\/pbmc20196501009","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T21:11:58Z","timestamp":1551215518000},"page":"9-20","source":"Crossref","is-referenced-by-count":4,"title":["Search for genetic markers for precise diagnostics of keratoconus"],"prefix":"10.18097","volume":"65","author":[{"given":"L.O.","family":"Skorodumova","sequence":"first","affiliation":[{"name":"Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.V.","family":"Belodedova","sequence":"additional","affiliation":[{"name":"Fyodorov Eye Microsurgery Complex Federal State Institution, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.I.","family":"Sharova","sequence":"additional","affiliation":[{"name":"Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.E.","family":"Malyugin","sequence":"additional","affiliation":[{"name":"Fyodorov Eye Microsurgery Complex Federal State Institution, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2019]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Romero-Jim\u00e9nez M., Santodomingo-Rubido J., Wolffsohn J.S. 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