{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T00:24:15Z","timestamp":1648945455606},"reference-count":15,"publisher":"Institute of Biochemistry","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>In socially isolated male outbred albino mice, the changes of monoaminergic systems under acute hypoxia  with hypercapnia were studied. In cerebral cortex, hippocampus and striatum of the right and left sides of the brain,  the concentrations of norepinephrine, dopamine, serotonin and their metabolites \u2013 dihydroxyphenylacetic,  homovanillic and 5-hydroxyindoleacetic acids were investigated using the HPLC method. In isolated mice, which were  not subjected to hypoxia with hypercapnia, higher levels of dopamine and serotonin in the left cortex were found.  There was no asymmetry in monoamines and their metabolites in other studied brain structures. 10 min after the onset  of exposure, acute hypoxia with hypercapnia resulted in a right-sided increase in norepinephrine levels and a decrease  in dopamine levels in the striatum and serotonin levels in the hippocampus. In the cerebral cortex, 10 min after  of hypoxic exposure beginning, there was a left-sided decrease in the dopamine content, while the original  asymmetry found in the cortex of intact animals disappeared. In isolated mice perished of hypoxia with hypercapnia,  almost all parameters returned to the control level. The exception was the ratio of serotonin metabolite level  to the neurotransmitter, which in the right cortex became lower than in control animals. In white outbred mice,  the brain monoaminergic systems are suggested to be relatively resistant to the negative consequences of hypoxia  and hypercapnia, and corresponding shifts resulting in the reflex brain response to changes in the gas composition  of the respiratory air.<\/jats:p>","DOI":"10.18097\/pbmc20196506485","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T07:32:26Z","timestamp":1577345546000},"page":"485-497","source":"Crossref","is-referenced-by-count":0,"title":["The time course of changes in the state of monoaminergic systems in the brain of mice under the acute hypoxia with hypercapnia"],"prefix":"10.18097","volume":"65","author":[{"given":"I.V.","family":"Karpova","sequence":"first","affiliation":[{"name":"Institute of Experimental Medicine, St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.V.","family":"Mikheev","sequence":"additional","affiliation":[{"name":"Kirov Military Medical Academy, St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.V.","family":"Marysheva","sequence":"additional","affiliation":[{"name":"Kirov Military Medical Academy, St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.A.","family":"Kuritcyna","sequence":"additional","affiliation":[{"name":"St. Petersburg State Pediatric Medical University, St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.R.","family":"Bychkov","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, St. Petersburg Russia; Kirov Military Medical Academy, St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.D.","family":"Shabanov","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, St. Petersburg Russia; Kirov Military Medical Academy, St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2019]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Karpova I.V., Mikheev V.V., Marysheva V.V., Bychkov E.R., Shabanov P.D. 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