{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T01:47:21Z","timestamp":1650419241093},"reference-count":9,"publisher":"Institute of Biochemistry","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The pharmacokinetics and bioavailability of a derivative of 3,7-diazabicyclo[3.3.1]nonane exhibiting  a nootropic effect, were studied after a single dose to rats. The pharmacokinetics of the compound was studied after  oral and intravenous administration to 270 male rats Sprague Dawley at doses of 2.5 mg\/kg, 13 mg\/kg and 25 mg\/kg.  Its distribution in organs and tissues (brain, thymus, heart, lungs, liver, kidneys, and spleen) was also investigated.  It was found that after a single intravenous administration, the investigated substance was determined in the blood  of animals for 24 h; the half-life was 4.69 h. The relative bioavailability of the 3,7-diazabicyclo[3.3.1]nonane derivative  after oral administration was 42.3%, thus suggesting the prospect of creating dosage forms for oral administration.  After a single oral administration, the dose dependence of AUC0-t was exponential. The substance is characterized  by heterogeneous distribution in the body with preferential accumulation mainly in well-vascularized tissues.<\/jats:p>","DOI":"10.18097\/pbmc20206601071","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T12:39:54Z","timestamp":1582893594000},"page":"71-76","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetic properties of an innovative nootropic agent based on a derivative of 3,7-diazabicyclo[3.3.1]nonane"],"prefix":"10.18097","volume":"66","author":[{"given":"G.E.","family":"Brkich","sequence":"first","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.V.","family":"Pyatigorskaya","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.V.","family":"Beregovykh","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Nedorubov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.V.","family":"Filippova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.A.","family":"Zyryanov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2020]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association (2018) American Stroke Association. Stroke. 49.3 DOI: 10.1161\/STR.0000000000000158.","DOI":"10.1161\/STR.0000000000000158"},{"key":"ref2","unstructured":"Hui C., Tadi P., Patti L. (2019) Ischemic Stroke Last Update www.ncbi.nlm.nih.gov\/books\/NBK499997\/."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Sergeev D.V., Domashenko M.A., Piradov M.A. (2017) Journal Neurology Psychiatry, 4, 86-91.","DOI":"10.17116\/jnevro20171174186-91"},{"key":"ref4","unstructured":"Pyatigorskaya N.V., Brkich G.E., Lavrov M.I., Palyulin V.A., Aladysheva Z.I. (2018) Journal Pharmaceutical Sciences Research, 10, 1103-1106."},{"key":"ref5","unstructured":"Zefirov N.S., Palyulin V.A., Lavrov M.I., Zapolsky M.E. (2013) patent RF No. 2480470. Appl. 2011113043 from 06.04.2011; publ. 27.04.2013 in BI No. 12."},{"key":"ref6","unstructured":"Lavrov M.I. (2011) Novel AMPA receptor modulators: design and assessment. Diss. kand. nauk, Lomonosov Moscow State University, Moscow]."},{"key":"ref7","unstructured":"State Pharmacopoeia of the Russian Federation XIV edition of OFS.1.1.0012.15 \u201cValidation of analytical methods\u201d."},{"key":"ref8","unstructured":"Decision of the Board of the Eurasian Economic Commission of July 17, 2018 N 113 \u201cOn approval of the Guidelines for the validation of analytical methodsfor testing drugs\u201d. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/www.alta.ru\/tamdoc\/18kr0113\/ \u0414\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 28.11.2019."},{"key":"ref9","unstructured":"Guidelines for preclinical studies of drugs. (2012) Part One (Mironov A.N., ed. ). M. Grif and K, 2012. 944."}],"container-title":["Biomeditsinskaya Khimiya"],"original-title":[],"language":"ru","deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T12:47:23Z","timestamp":1582894043000},"score":1,"resource":{"primary":{"URL":"http:\/\/pbmc.ibmc.msk.ru\/en\/article-en\/PBMC-2020-66-1-71"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020]]},"published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.18097\/pbmc20206601071","relation":{},"ISSN":["2310-6905","2310-6972"],"issn-type":[{"value":"2310-6905","type":"electronic"},{"value":"2310-6972","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}