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It is noteworthy that in the analysis of fecal matter in obese children, revealed a 2-fold increase  in the level of kynurenine while the concentration of kynurenine pathway metabolites corresponded to the level  of the group of healthy children. This may indicate the metabolic activation of the microbiota associated with  the intestinal mucosa. This is also supported by the absence of statistically significant differences in the concentration  of indole in healthy children and in obese children in fecal analyses, and a significant increase in the concentration  of indole-3-lactate and indole-3-acetate in the blood serum of obese children.<\/jats:p>","DOI":"10.18097\/pbmc20206606494","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T06:17:32Z","timestamp":1609222652000},"page":"494-501","source":"Crossref","is-referenced-by-count":7,"title":["The study of tryptophan metabolite concentrations in blood serum and fecal extracts from obese children"],"prefix":"10.18097","volume":"66","author":[{"given":"A.V.","family":"Shestopalov","sequence":"first","affiliation":[{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; Center for digital and translational Biomedicine \u201cCenter for Molecular Health\u201d, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.P.","family":"Shatova","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Gaponov","sequence":"additional","affiliation":[{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; Center for digital and translational Biomedicine \u201cCenter for Molecular Health\u201d, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.E.","family":"Moskaleva","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Appolonova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.V.","family":"Tutelyan","sequence":"additional","affiliation":[{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.V.","family":"Makarov","sequence":"additional","affiliation":[{"name":"Center for Strategic Planning and Management of Biomedical Health Risks, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Yudin","sequence":"additional","affiliation":[{"name":"Center for Strategic Planning and Management of Biomedical Health Risks, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Rumyantsev","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University, Moscow, Russia; Center for digital and translational Biomedicine \u201cCenter for Molecular Health\u201d, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7443","published-online":{"date-parts":[[2020]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Comai S., Bertazzo A., Brughera M., Crotti S. 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