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The presence of CaCC  has also been recognized in the vascular muscles, smooth muscles of the respiratory tract, which control vascular tone  and hypersensitivity of the respiratory tract. TMEM16A is activated in many cancers; it is believed that TMEM16A  is involved in carcinogenesis. TMEM16A is also involved in cancer cells proliferation. The role of TMEM16A  in the mechanisms of hypertension, asthma, cystic fibrosis, nociception, and dysfunction of the gastrointestinal tract  has been determined. In addition to TMEM16A, its isoforms are involved in other physiological and pathophysiological  processes. TMEM16B (or ANO2) is involved in the sense of smell, while ANO6 works like scramblase, and its mutation  causes a rare bleeding disorder, known as Scott syndrome. ANO5 is associated with muscle and bone diseases.  TMEM16A interacts with various cellular signaling pathways including: epidermal growth factor receptor (EGFR),  mitogen-activated protein kinases (MAPK), calmodulin (CaM) kinases, transforming growth factor TGF-\u03b2. The review  summarizes existing information on known natural and synthetic compounds that can block\/modulate CaCC currents  and their effect on some pathologies in which CaCC is involved.<\/jats:p>","DOI":"10.18097\/pbmc20216701017","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T11:27:52Z","timestamp":1614598072000},"page":"17-33","source":"Crossref","is-referenced-by-count":8,"title":["Calcium-activated chloride channels: structure, properties, role in physiological and pathological processes"],"prefix":"10.18097","volume":"67","author":[{"given":"V.V.","family":"Grigoriev","sequence":"first","affiliation":[{"name":"Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2021]]},"reference":[{"key":"ref1","unstructured":"Fuller C.M. (2002) Calcium-activated chloride channels. 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