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The treatment of an invasive  form of bronchopulmonary aspergillosis is directly related to the immunomodulatory and immunostimulating  properties of the macrocyclic polyene drug amphotericin B. The article presents experimental data on the study  of the biological activity and membrane properties of amphotericin B and the effect of its chemically modified  derivatives, as well as liposomal forms of amphotericin B on viral, bacterial and fungal infections. The mechanism  of action of amphotericin B and its analogues is based on their interaction with cellular and lipid membranes,  by forming ion channels of molecular size in them. The importance of these studies is that polyenes are sensitive  to membranes that contain sterols of a certain structure. The analysis showed that pathogenic fungal cells containing  ergosterol were 10-100 times more sensitive to polyene antibiotics than host cell membranes containing cholesterol.  The high sterol selectivity of the action of polyenes opens up broad prospects for the use of polyene antifungal drugs  in practical medicine and pharmacology in the treatment of invasive mycoses and the prevention of atherosclerosis.  In this connection, it should be noted that polyene antibiotics are the main tool in the study of the biochemical  mechanism of changes in the permeability of cell membranes for energy-dependent substrates. Chemical and genetic  engineering transformation of the structure of polyene antibiotic molecules opens up prospects for the identification  and creation of new biologically active forms of the antibiotic that have a high selectivity of action in the treatment  of pathogenic infections.<\/jats:p>","DOI":"10.18097\/pbmc20216704311","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T12:03:58Z","timestamp":1629461038000},"page":"311-322","source":"Crossref","is-referenced-by-count":0,"title":["Antifungal macrocycle antibiotic amphotericin B \u2014 its present and future. 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