{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:29:21Z","timestamp":1769599761113,"version":"3.49.0"},"reference-count":25,"publisher":"Institute of Biochemistry","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>A comparative analysis of molecular genetic phenotypes of mucous membrane cells in five anatomical regions  of the colon in a group of healthy donors was conducted by comparing mRNA expression profiles of 62 genes  involved in the regulation of vital cellular function. We used 181 biopsy samples of morphologically unchanged  colonic mucosa, obtained from the colon (ascending, transverse-colon, descending, sigmoid) and rectum sections  during prophylactic colonoscopy of 58 donors with no colon pathology. The mRNA levels for 62 genes involved  in the regulation of apoptosis, proliferation, transcription, differentiation, cell-cell adhesion, and immune response were  assessed by RT-PCR. Statistically significant differences were found for the molecular phenotypes of five sections  of the colon. The results of the study can serve as a basis for creating a reference database (values of expression profiles),  developing methods of differential diagnostics and screening of various pathologies of the colon.<\/jats:p>","DOI":"10.18097\/pbmc20216704366","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T12:03:58Z","timestamp":1629461038000},"page":"366-373","source":"Crossref","is-referenced-by-count":1,"title":["The study of mRNA expression profiles of main cell function regulator genes in unchanged colonic mucosa from healthy donors"],"prefix":"10.18097","volume":"67","author":[{"given":"M.V.","family":"Zakharenko","sequence":"first","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.K.","family":"Bozhenko","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya.Yu.","family":"Kiseleva","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.L.","family":"Dzhikiya","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.S.","family":"Stanoevich","sequence":"additional","affiliation":[{"name":"Kursk Regional Clinical Oncology Center, Kislino, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Kulinich","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.V.","family":"Melnikova","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L.","family":"Senchukova","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.B.","family":"Urakova","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.B.","family":"Grunin","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.V.","family":"Goncharov","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.P.","family":"Bliznyukov","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.A.","family":"Solodkiy","sequence":"additional","affiliation":[{"name":"Russian Scientific Center of Roentgenoradiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2021]]},"reference":[{"key":"ref1","unstructured":"Dobrovolsky O.V., Serebrova S.Yu. (2007) RMJ, 15(16), 1193-1198."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Paschke S., Jafarov S., Staib L., Kreuser E.D., Maulbecker-Armstrong C., Roitman M., Holm T., Harris C.C., Link K.H., Kornmann M. (2018) Int. J. Mol. Sci., 19(9), 2577.","DOI":"10.3390\/ijms19092577"},{"key":"ref3","unstructured":"Glebov O.K., Rodriguez L.M., Nakahara K., Jenkins J., Cliatt J., Humbyrd C.-J., DeNobile J., Soballe P., Simon R., Wright G., Lynch P., Patterson S., Lynch H., Gallinger S., Buchbinder A., Gordon G., Hawk E., Kirsch I.R. (2003) Cancer Epidemiol. Biomarkers Prev., 12(8), 755-762."},{"key":"ref4","unstructured":"Churkin I.A. (2002) Primenenie pricel&apos;noj endoskopicheskoj rN-metrii dlya ocenki funkcional&apos;nogo sostoyaniya slizistoj pryamoj i sigmovidnoj obodochnoj kishki. Avtoref. diss. kand. nauk. Altajskij Gosudarstvennyj Medicinskij Universitet MZ RF, Tomsk."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Distler P., Holt P.R. (1997) Dig. Dis., 15, 302-311.","DOI":"10.1159\/000171605"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Iacopetta B. (2002) Int. J. Cancer, 101(5), 403-408.","DOI":"10.1002\/ijc.10635"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Benedix F., Kube R., Meyer F., Schmidt U., Gastinger I., Lippert H. (2010) Dis. Colon Rectum., 53(1), 57-64.","DOI":"10.1007\/DCR.0b013e3181c703a4"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Forster S., Sattler H.P., Hack M., Romanakis K., Rohde V., Seitz G., Wullich B. (1998) Surgery., 123(1), 13-18.","DOI":"10.1016\/S0039-6060(98)70223-5"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Hinoue T., Weisenberger D.J., Lange C.P., Shen H., Byun H.-M., van den Berg D., Malik S., Pan F., Noushmehr H., van Dijk C.M., Tollenaar R.A.E.M., Laird P.W. (2012) Genome Res., 22, 271-282.","DOI":"10.1101\/gr.117523.110"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Yamauchi M., Lochhead P., Morikawa T., Huttenhower C., Chan A.T., Giovannucci E., Fuchs C., Ogino S. (2012) Gut, 61(6), 794-797.","DOI":"10.1136\/gutjnl-2012-302014"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Aran D., Camarda R., Odegaard J., Paik H., Oskotsky B., Krings G., Goga A., Sirota M., Butte A.J. (2017) Nat. Commun., 8(1), 1077.","DOI":"10.1038\/s41467-017-01027-z"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Sanz-Pamplona R., Berenguer A., Cordero D., Mollev\u00ed D.G., Crous-Bou M., Sole X., Par\u00e9-Brunet L., Guino E., Salazar R., Santos C., de Oca J., Sanjuan X., Rodriguez-Moranta F., Moreno V. (2014) Mol. Cancer., 13, 46.","DOI":"10.1186\/1476-4598-13-46"},{"key":"ref13","unstructured":"Stanoevich U. (2017) Klinicheskoe znachenie rezul&apos;tatov molekulyarno-geneticheskih issledovanij tolstoj kishki pri kolorektal&apos;nom rake. Diss. dokt. med. nauk. FGBU Rossijskij nauchnyj centr rentgenoradiologii Ministerstva zdravoohraneniya Rossijskoj Federacii, Moskva."},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Bozhenko V.K., Stanoevich U.S., Trotsenko I.D., Zakharenko M.V., Kiseleva Ya.Yu., Solodky V.A. (2018) Biomeditsinskaya Khimiya, 64(1), 46-52.] DOI: 10.18097\/PBMC20186401046.","DOI":"10.18097\/PBMC20186401046"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Kulinich T.M., Zakharenko M.V., Dzhikiya E.L., Senchukova A.L., Stanoevich U.S., Grunin I.B., Melnikova N.V., Goncharov S.V., Krashikhina T.V., Kudinova E.A., Bliznyukov O.P., Bozhenko V.K. (2020) Uspekhi Molekulyarnoy Oncologii, 7(2), 39-46.","DOI":"10.17650\/2313-805X-2020-7-2-39-46"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Dowling C.M., Walsh D., Coffey J.C., Kiely P.A. (2016) F1000Research, 5, 99.","DOI":"10.12688\/f1000research.7656.1"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"de Kok J., Roelofs R., Giesendorf B. (2005) Lab. Invest., 85, 154-159.","DOI":"10.1038\/labinvest.3700208"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Wang H., Wang J., Zhao Y., Zhang X., Liu J., Zhang C., Haffty B., Verzi M., Zhang L., Gao N., Feng Z., Hu W. (2020) Cell Death Dis., 11(7), 588.","DOI":"10.1038\/s41419-020-02790-6"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"McTernan P.G., Anderson L.A., Anwar A.J., Eggo M.C., Crocker J., Barnett A.H., Stewart P.M., Kumar S. (2002) J. Clin. Endocrinol. Metab., 87(3), 1327-1336.","DOI":"10.1210\/jcem.87.3.8288"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Murphy N., Carreras-Torres R., Song M., Martin R.M., Tsilidis K.K., Smith-Byrne K., Fensom G., Perez-Cornago A., Travis R.C., Key T.J. (2020) Gastroenterology, 158, 1300-1312. e20.","DOI":"10.1053\/j.gastro.2019.12.020"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Kasprzak A., Szaflarski W. (2020) Int. J. Mol. Sci., 21(19), 6995.","DOI":"10.3390\/ijms21196995"},{"key":"ref22","unstructured":"Bozhenko V.K., Zakharenko M.V., Kulinich T.M., Dzhikia E.L., Senchukova A.L., Stanoevich U.S., Grunin I.B., Melnikova N.V., Krashikhina T.V., Bliznyukov O.P., Goncharov S.V., Kudinova E.A. (2020) Vestnik RNCRR, 20(3), 15-39."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Song Q., Li C., Feng X., Yu A., Tang H., Peng Z., Wang X. (2015) Oncol. Rep., 33(4), 1956-1964.","DOI":"10.3892\/or.2015.3790"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Tsai M.T., Cheng C.J., Lin Y.C., Chen C.C., Wu A.R., Wu M.T., Hsu C.C., Yang R.B. (2009) Biochem. J., 422(1), 119-128.","DOI":"10.1042\/BJ20090341"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Rawla P., Sunkara T., Barsouk A. (2019) Prz. Gastroenterol., 14(2), 89-103.","DOI":"10.5114\/pg.2018.81072"}],"container-title":["Biomeditsinskaya Khimiya"],"original-title":[],"language":"ru","deposited":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T12:05:28Z","timestamp":1629461128000},"score":1,"resource":{"primary":{"URL":"http:\/\/pbmc.ibmc.msk.ru\/en\/article-en\/PBMC-2021-67-4-366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021]]},"published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.18097\/pbmc20216704366","relation":{},"ISSN":["2310-6905","2310-6972"],"issn-type":[{"value":"2310-6905","type":"electronic"},{"value":"2310-6972","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]}}}