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The results of such studies can be useful for the development of new markers of the degree of alcohol intoxication of the body for the subsequent choice of the method drug correction of disorders caused by acute or chronic alcohol effects. The review summarizes results in vivo and in vitro of studies performed during more than 60 years on the effect of ethanol on the biogenesis, number, morphology and biochemistry of platelets.<\/jats:p>","DOI":"10.18097\/pbmc20226802081","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T10:31:19Z","timestamp":1651228279000},"page":"81-92","source":"Crossref","is-referenced-by-count":0,"title":["Effect of ethanol on platelet biology"],"prefix":"10.18097","volume":"68","author":[{"given":"M.I.","family":"Airapetov","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology, Institute of Experimental Medicine, Saint Petersburg, Russia; Department of Pharmacology, St. Petersburg State Pediatric Medical University, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.O.","family":"Eresko","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Institute of Experimental Medicine, Saint Petersburg, Russia; Research and Training Center of Molecular and Cellular Technologies, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.R.","family":"Bychkov","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Institute of Experimental Medicine, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Lebedev","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Institute of Experimental Medicine, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.D.","family":"Shabanov","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Institute of Experimental Medicine, Saint Petersburg, Russia; Department of Pharmacology, Kirov Military Medical Academy, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7443","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Kissin B., Begleiter H. 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(2016) Molecular and Cellular Biology of Platelet Formation., Springer International Publishing Switzerland, Switzerland, Cham, 460 p.","DOI":"10.1007\/978-3-319-39562-3"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Moreau T., Evans A.L., Vasquez L. et al. (2016) Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Nat. Commun., 7, 1-16.","DOI":"10.1038\/ncomms11208"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Wilde M.I., Faulds D. (1998) Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs, 10, 159-171.","DOI":"10.2165\/00063030-199810020-00006"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Huising M.O., Kruiswijk C.P., van Schijndel J.E., Savelkoul H.F., Flik G., Verburg-van Kemenade B.M. (2005) Multiple and highly divergent IL-11 genes in teleost fish. Immunogenetics, 57(6), 432-443.","DOI":"10.1007\/s00251-005-0012-2"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Clancy L., Beaulieu L.M., Tanriverdi K., Freedman J.E. (2017) The role of RNA uptake in platelet heterogeneity. Thromb. Haemost., 117(5), 948-961.","DOI":"10.1160\/TH16-11-0873"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Solari F.A., Mattheij N.J.A., Burkhart J.M. et al. (2016) Combined quantification of the global proteome, phosphoproteome and protein cleavage to characterize altered platelet functions in the human Scott syndrome. Mol. Cell. Proteomics, 15(10), 3154-3169.","DOI":"10.1074\/mcp.M116.060368"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Baaten C.C.F.M.J., Ten C.H., Meijden P.E.J., Heemskerk J.W.M. (2017) Platelet populations and priming in hematological diseases. Blood Rev., 31(6), 389-399.","DOI":"10.1016\/j.blre.2017.07.004"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Meijden P.E.J., Heemskerk J.W.M. (2018) Platelet biology and functions: new concepts and clinical perspectives. Nature Reviews Cardiology, 16(3), 166-179.","DOI":"10.1038\/s41569-018-0110-0"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Zeiler M., Moser M., Mann M. (2014) Copy number analysis of the murine platelet proteome spanning the complete abundance range. Mol. Cell. Proteom., 13(12), 3435-3445.","DOI":"10.1074\/mcp.M114.038513"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Shi D.S., Smith M.C.P., Campbell R.A. et al. (2014) Proteasome function is required for platelet production. J. Clin. Invest., 124(9), 3757-3766.","DOI":"10.1172\/JCI75247"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Semeniak D., Kulawig R., Stegner D. et al. (2016) Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling. J. Cell Sci., 129(18), 3473-3484.","DOI":"10.1242\/jcs.187971"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Quach M.E., Chen W., Li R. (2018) Mechanisms of platelet clearance and translation to improve platelet storage. Blood, 131(14), 1512-1521.","DOI":"10.1182\/blood-2017-08-743229"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Girish S., Komal H., Ghanshyam P. et al. (2021) Platelet augmentation potential of polyherbal formulation in cyclophosphamide-induced thrombocytopenia in Wistar rat. Folia Med (Plovdiv), 63(1), 67-73.","DOI":"10.3897\/folmed.63.e49167"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Rudmann D.G., Page T.J., Vahle J.L. et al. (2011) Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol. Sci., 125(2), 586-594.","DOI":"10.1093\/toxsci\/kfr318"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Okamoto M., Miyazawa T., Morikawa S. et al. (2015) Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host. Sci. Rep., 5(1), 8850.","DOI":"10.1038\/srep08850"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Goggs R., Boag A.K., Chan D.L. (2008) Concurrent immune-mediated haemolytic anaemia and severe thrombocytopenia in 21 dogs. Veterinary Record, 163(11), 323-327.","DOI":"10.1136\/vr.163.11.323"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Koenhemsi L. (2019) Determination of platelet count and platelet indices in Canine Parvoviral Enteritit. Medical Science Discovery, 6(2), 24-26.","DOI":"10.17546\/msd.522081"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Yang C., Chun L.Y., Kuter D.J. (1999) The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat. Br. J. Haematol., 105(2), 478-485.","DOI":"10.1111\/j.1365-2141.1999.01359.x"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Teixeira M.A., Chaguri L.C.A.G., Carissimi A.S. et al. (2000) Hematological and biochemical profiles of rats (Rattus norvegicus) kept under microenvironmental ventilation system. Brazilian J. Veterinary Research Animal Science, 37(5), 341-347.","DOI":"10.1590\/S1413-95962000000500001"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Yamashita K.M., Nogueira T.O., Senise L.V. et al. (2011) Involvement of circulating platelets on the hyperalgesic response evoked by carrageenan and Bothrops jararaca snake venom. J. Thromb. Haemost., 9(10), 2057-2066.","DOI":"10.1111\/j.1538-7836.2011.04449.x"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Kobuchi S., Ito Y., Hayakawa T. et al. (2014) Semi-physiological pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats. Xenobiotica, 45(1), 19-28.","DOI":"10.3109\/00498254.2014.943335"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Crow A.R., Song S., Semple J.W. et al. (2001) IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity. Br. J. Haematol., 115(3), 679-686.","DOI":"10.1046\/j.1365-2141.2001.03136.x"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Ross R., Bowen-Pope D.F., Raines E.W. (1985) Platelets, macrophages, endothelium, and growth factors. Their effects upon cells and their possible roles in atherogenesis. Ann. NY Acad. Sci., 454, 254-260.","DOI":"10.1111\/j.1749-6632.1985.tb11865.x"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Hawrylowicz C.M., Howells G.L., Feldmann M. (1991) Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J. Exp. Med., 174(4), 785-790.","DOI":"10.1084\/jem.174.4.785"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Ramadori P., Klag T., Malek N.P., Heikenwalder M. (2019) Platelets in chronic liver disease, from bench to bedside. JHEP Reports, 1(6), 448-459.","DOI":"10.1016\/j.jhepr.2019.10.001"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Orian J.M., D'Souza C.S., Kocovski P. et al. (2021) Platelets in multiple sclerosis: early and central mediators of inflammation and neurodegeneration and attractive targets for molecular imaging and site-directed therapy. Front. Immunol., 12, 620963.","DOI":"10.3389\/fimmu.2021.620963"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Silczuk A., Habrat B. (2020) Alcohol induced thrombocytopenia. Current review. Alcohol, 86, 9-16.","DOI":"10.1016\/j.alcohol.2020.02.166"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Cowan D.H. (1971) Thrombocytopenia of severe alcoholism. Ann. Intern. Med., 74(1), 37.","DOI":"10.7326\/0003-4819-74-1-37"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Sullivan L.W., Herbert V. (1964) Suppression hematopoiesis by ethanol. J. Clin. Investig., 43, 2048-2062.","DOI":"10.1172\/jci105079"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Lindenbaum J., Hargrove R.L. (1968) Thrombocytopenia in alcoholics. Ann. Intern. Med., 68, 526-532.","DOI":"10.7326\/0003-4819-68-3-526"},{"key":"ref38","unstructured":"Paraf A., Coste T., Gouffier E. (1971) Disorders of hematopoiesis in acute alcoholism. Presse. Med., 79(49), 2219-2220."},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Eichner E.R. (1973) The hematologic disorders of alcoholism. Am. J. Med., 54, 621-630.","DOI":"10.1016\/0002-9343(73)90120-4"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Peltz S. (1991) Severe thrombocytopenia secondary to alcohol use. Postgraduate Medicine, 89(6), 75-85.","DOI":"10.1080\/00325481.1991.1170091"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Bakovic D., Pivac N., Eterovic D. et al. (2013) The effects of low-dose epinephrine infusion on spleen size, central and hepatic circulation and circulating platelets. Clin. Physiol. Funct. Imaging, 33(1), 30-37.","DOI":"10.1111\/j.1475-097X.2012.01156.x"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Chen S., Du C., Shen M. et al. (2016) Sympathetic stimulation facilitates thrombopoiesis by promoting megakaryocyte adhesion, migration, and proplatelet formation. Blood, 127(8), 1024-1035.","DOI":"10.1182\/blood-2015-07-660746"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Mitchell O., Feldman D.M., Diakow M., Sigal S.H. (2016) The pathophysiology of thrombocytopenia in chronic liver disease. Hepatic Medicine: Evidence and Research, 8, 39-50.","DOI":"10.2147\/hmer.S74612"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Peck-Radosavljevic M. (2016) Thrombocytopenia in chronic liver disease. Liver International, 37(6), 778-793.","DOI":"10.1111\/liv.13317"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Leon C., Dupuis A., Gachet C., Lanza F. (2016) The contribution of mouse models to the understanding of constitutional thrombocytopenia. Haematologica, 101(8), 896-908.","DOI":"10.3324\/haematol.2015.139394"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Post R.M., Desforges J.F. (1968) Thrombocytopenia and alcoholism. Ann. Intern. Med., 68, 1230-1236.","DOI":"10.7326\/0003-4819-68-6-1230"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Lindenbaum J., Lieber C.S. (1969) Hematologic effects of alcohol in man in the absence of nutritional deficiency. N. Engl. J. Med., 281(7), 333-338.","DOI":"10.1056\/NEJM196908142810701"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Yokoyama A., Yokoyama T., Mizukami T., Matsui T., Kimura M., Matsushita S., Maruyama K. (2016) Platelet counts and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in japanese alcoholic men. Alcohol. Clin. Exp. Res., 41(1), 171-178.","DOI":"10.1111\/acer.13283"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Liu L., Chen M., Zhao L. et al. (2017) Ethanol induces platelet apoptosis. Alcohol. Clin. Exp. Res., 41(2), 291-298.","DOI":"10.1111\/acer.13295"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Maturu P., Reddy V.D., Padmavathi P., Varadacharyulu N. (2012) Ethanol induced adaptive changes in blood for the pathological and toxicological effects of chronic ethanol consumption in humans. Exper. Toxicol. Pathol., 64(7-8), 697-703.","DOI":"10.1016\/j.etp.2011.01.002"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Vo Q.T., Thompson D.F. (2019) A review and assessment of drug-induced thrombocytosis. Ann. Pharmacother., 53(5), 523-536.","DOI":"10.1177\/1060028018819450"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Harshe D.G., Thadasare H., Karia S.B. (2017) A study of patterns of platelet counts in alcohol withdrawal. Indian J. Psychol. Med., 39(4), 441-444.","DOI":"10.4103\/0253-7176.211766"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"Michot F., Gut J. (1987) Alcohol-induced bone marrow damage. Acta Haematologica, 78(4), 252-257.","DOI":"10.1159\/000205888"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Latvala J., Parkkila S., Niemela O. (2004) Excess alcohol consumption is common in patients with cytopenia: Studies in blood and bone marrow cells. Alcohol. Clin. Exp. Res., 28(4), 619-624.","DOI":"10.1097\/01.alc.0000122766.54544.3b"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Orum M.H., Kara M.Z. (2019) Platelet to lymphocyte ratio (PLR) in alcohol use disorder. J. Immunoassay Immunochem., 41(2), 184-194.","DOI":"10.1080\/15321819.2019.1705853"},{"key":"ref56","unstructured":"Smith C.M., Tobin J.D., Burris S.M., White J.G. (1992) Alcohol consumption in the Guinea pig is associated with reduced megakaryocyte deformability and platelet size. J. Lab. Clin. Med., 120, 699-706."},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Tisman G., Herbert V. (1973) In vitro myelosuppression and immunosuppression by ethanol. J. Clin. Invest., 52(6), 1410-1414.","DOI":"10.1172\/JCI107314"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Airapetov M., Eresko S., Lebedev A., Bychkov E., Shabanov P. (2021) The role of Toll-like receptors in neurobiology of alcoholism. Biosci. Trends, 15(2), 74-82.","DOI":"10.5582\/bst.2021.01041"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Haut M.J., Cowan D.H. (1974) The effect of ethanol on hemostatic properties of human blood platelets. Am. J. Med., 56(1), 22-33.","DOI":"10.1016\/0002-9343(74)90747-5"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"Littleton J.M., Fenn C.G., Umney N.D., Yazdanbakhsh M. (1982) Effects of ethanol administration on platelet function in the rat. Alcohol. Clin. Exp. Res., 6(4), 512-519.","DOI":"10.1111\/j.1530-0277.1982.tb05015.x"},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"Baker R.C., Fish H.T., Fitzpatrick F.A. (1989) Effects of ethanol on human platelets stimulated with platelet-activating factor, a biologically active ether phospholipid. Alcohol. Clin. Exp. Res., 13(6), 824-828.","DOI":"10.1111\/j.1530-0277.1989.tb00430.x"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"Hwang D.H., LeBlanc P., Chanmugan P. (1981) In vitro and in vivo effects of ethanol on the formation of endoperoxide metabolites in rat platelets. Lipids, 16(8), 583-588.","DOI":"10.1007\/bf02534903"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"Renaud S.C., Ruf J.C. (1996) Effects of alcohol on platelet functions. Clinica Chimica Acta, 246(1-2), 77-89.","DOI":"10.1016\/0009-8981(96)06228-6"},{"key":"ref64","unstructured":"Hillbom M. (1985) Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. Thromb. Haemost., 53(3), 419-422. PMID: 4049313."},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"Abbott L., Nadler J., Rude R.K. (1994) Magnesium deficiency in alcoholism: possible contribution to osteoporosis and cardiovascular disease in alcoholics. Alcohol. Clin. Exp. Res., 18(5), 1076-1082.","DOI":"10.1111\/j.1530-0277.1994.tb00084.x"},{"key":"ref66","doi-asserted-by":"publisher","unstructured":"Ge P.X., Jiang L.P., Tai T., Zhu T., Ji J.Z., Li Y.F., Xie H.G. (2021) Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2\/Ces1 pathway and induction of Cyp2c in mice. Life Sci., 279, 119268.","DOI":"10.1016\/j.lfs.2021.119268"},{"key":"ref67","doi-asserted-by":"publisher","unstructured":"Lex B.W., Ellingboe J., LaRosa K., Teoh S.K., Mendelson J.H. (1993) Platelet adenylate cyclase and monoamine oxidase in women with alcoholism or a family history of alcoholism. Harvard Rev. Psychiatry, 1(4), 229-237.","DOI":"10.3109\/10673229309017083"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"Tabakoff B., Hoffman P.L., Lee J.M. et al. (1988) Differences in platelet enzyme activity between alcoholics and nonalcoholics. N. Engl. J. Med., 318(3), 134-139.","DOI":"10.1056\/NEJM198801213180302"},{"key":"ref69","unstructured":"Chabielska E., Pietraszek M., Malinowska B., Buczko W. (1988) The effect of ethanol on some serotonergic mechanisms in rat blood platelets. Pol. J. Pharmacol. Pharm., 40(3), 241-249."},{"key":"ref70","doi-asserted-by":"publisher","unstructured":"Nedic Erjavec G., Bektic Hodzic J., Repovecki S., Nikolac Perkovic M., Uzun S., Kozumplik O., Tudor L., Mimica N., Svob Strac D., Pivac N. (2021) Alcohol-related phenotypes and platelet serotonin concentration. Alcohol, 97, 41-49.","DOI":"10.1016\/j.alcohol.2021.09.001"},{"key":"ref71","doi-asserted-by":"publisher","unstructured":"Pattiselanno S., Gunning W., Schoffelmeer A. (1994) Adenylate cyclase, a biochemical marker of alcoholism? Acta Paediatrica, 83(404), 1-3.","DOI":"10.1111\/j.1651-2227.1994.tb13374.x"},{"key":"ref72","doi-asserted-by":"publisher","unstructured":"Miceli M., Alberti L., Bennardini F. et al. (2003) Effect of low doses of ethanol on platelet function in long-life abstainers and moderate-wine drinkers. Life Sci., 73(12), 1557-1566.","DOI":"10.1016\/s0024-3205(03)00473-9"},{"key":"ref73","doi-asserted-by":"publisher","unstructured":"Atkinson J.P., Sullivan T.J., Kelley J.P., Parker C.W. (1977) Stimulation by alcohols of cyclic AMP metabolism in human leukocytes. J. Clin. Invest., 60(2), 284-294.","DOI":"10.1172\/JCI108776"},{"key":"ref74","doi-asserted-by":"publisher","unstructured":"Hoffman P.L., Tabakoff B. (1990) Ethanol and guanine nucleotide binding proteins: a selective interaction. FASEB J., 4(9), 2612-2622.","DOI":"10.1096\/fasebj.4.9.2161371"},{"key":"ref75","doi-asserted-by":"publisher","unstructured":"Hwang D.H., Chanmugam P., Hymel G., Boudreau M. (1987) Effects of chronic ethanol ingestion on arachidonic acid metabolism in rat tissues and in vitro effect of ethanol on camp in platelets. Prostaglandins, Leukotrienes and Medicine, 26(3), 299-305.","DOI":"10.1016\/0262-1746(87)90039-4"},{"key":"ref76","doi-asserted-by":"publisher","unstructured":"Dong Q.S., Wroblewska B., Myers A.K. (1995) Inhibitory effect of alcohol on cyclic GMP accumulation in human platelets. Thromb. Res., 80(2), 143-151.","DOI":"10.1016\/0049-3848(95)00160-S"},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"McKenzie M.E., Bell C.R., Horowitz E.D. et al. (2002) Effects of in vitro exposure of alcohol on surface receptor expression of human platelets. Clin. Physiol. Funct. Imaging, 22(2), 153-156.","DOI":"10.1046\/j.1365-2281.2002.00411.x"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"Stach K., Kalsch A.I., Weiss C. et al. (2012) Effects of ethanol on the properties of platelets and endothelial cells in model experiments. World J. Cardiol., 4(6), 201-205.","DOI":"10.4330\/wjc.v4.i6.201"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"Sage S.O., Reast R., Rink T.J. (1990) ADP evokes biphasic Ca2+ influx in fura-2-loaded human platelets. Evidence for Ca2+ entry regulated by the intracellular Ca2+ store. Biochem. J., 265(3), 675-680.","DOI":"10.1042\/bj2650675"},{"key":"ref80","doi-asserted-by":"publisher","unstructured":"Sage S.O. (1997) The Wellcome Prize Lecture. Calcium entry mechanisms in human platelets. Exp. Physiol, 82(5), 807-823.","DOI":"10.1113\/expphysiol.1997.sp004066"},{"key":"ref81","doi-asserted-by":"publisher","unstructured":"Berridge M.J. (1997) The AM and FM of calcium signalling. Nature, 386(6627), 759-760.","DOI":"10.1038\/386759a0"},{"key":"ref82","doi-asserted-by":"publisher","unstructured":"Kasuda S., Sakurai Y., Shima M. et al. (2006) Inhibition of PAR4 signaling mediates ethanol-induced attenuation of platelet function in vitro. Alcohol. Clin. Exp. Res., 30(9), 1608-1614.","DOI":"10.1111\/j.1530-0277.2006.00193.x"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"Wakabayashi I., Marumo M. (2002) Ethanol inhibits store-operated Ca2+ entry of platelets. Pharmacol. Toxicol., 90(4), 226-228.","DOI":"10.1034\/j.1600-0773.2002.900410.x"},{"key":"ref84","doi-asserted-by":"publisher","unstructured":"Rosado J.A., Nunez A.M., Parients J.A., Salido G.M. (2006) Alterations in intracellular calcium homeostasis and platelet aggregation induced by ethanol. Biochem. Biophys. Res. Commun., 341(4), 917-924.","DOI":"10.1016\/j.bbrc.2006.01.056"},{"key":"ref85","doi-asserted-by":"publisher","unstructured":"Mitidieri F., de Meis L. (1995) Ethanol has different effects on Ca2+-transport ATPases of muscle, brain and blood platelets. Biochem. J., 312(3), 733-737.","DOI":"10.1042\/bj3120733"},{"key":"ref86","doi-asserted-by":"publisher","unstructured":"Marumo M., Wakabayashi I. (2010) Diverse effects of ethanol on Ca2+ entry and subsequent aggregation of platelets. Alcohol, 44(4), 343-350.","DOI":"10.1016\/j.alcohol.2010.02.002"},{"key":"ref87","doi-asserted-by":"publisher","unstructured":"Benistant C., Rubin R. (1990) Ethanol inhibits thrombininduced secretion by human platelets at a site distinct from phospholipase C or protein kinase C. Biochem. J., 269(2), 489-497.","DOI":"10.1042\/bj2690489"},{"key":"ref88","doi-asserted-by":"publisher","unstructured":"Nguyen A., Packham M.A., Rand M.L. (1999) Effects of ethanol on platelet responses associated with adhesion to collagen. Thromb. Res., 95(6), 303-314.","DOI":"10.1016\/s0049-3848(99)00050-x"},{"key":"ref89","unstructured":"Nguyen A., Gemmell C.H., Yeo E.L. et al. (1998) Ethanol inhibits thrombin-induced secretion of the contents of human platelet dense and alpha-granules and lysosomes. Thromb. Haemost., 80(4), 662-667."},{"key":"ref90","doi-asserted-by":"publisher","unstructured":"Manku M.S., Horrobin D.I. (1979) Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. Prostagland. Med., 3(2), 119-128.","DOI":"10.1016\/0161-4630(79)90079-x"},{"key":"ref91","doi-asserted-by":"publisher","unstructured":"Salem R.O., Laposata M. (2005) Effects of alcohol on hemostasis. Am. J. Clin. Pathol., 123, 96-105.","DOI":"10.1309\/113N8EUFXYUECCNA"},{"key":"ref92","doi-asserted-by":"publisher","unstructured":"Hillbom M., Kangasaho M., L\u00f6wbeer C. et al. (1985) Effects of ethanol on platelet function. Alcohol, 2(3), 429-432.","DOI":"10.1016\/0741-8329(85)90109-0"},{"key":"ref93","doi-asserted-by":"publisher","unstructured":"Dunn E.L. (1981) Acute alcohol ingestion and platelet function. Archives Surgery, 116(8), 1082-1083.","DOI":"10.1001\/archsurg.1981.01380200078016"},{"key":"ref94","doi-asserted-by":"publisher","unstructured":"Pennington S.N., Smith C.P. (1979) The effect of ethanol on thromboxane synthesis by blood platelets. Prostagland. Med., 2(1), 43-49.","DOI":"10.1016\/s0161-4630(79)80007-5"},{"key":"ref95","doi-asserted-by":"publisher","unstructured":"Helander A., Tottmar O. (1987) Effects of ethanol, acetaldehyde and disulfiram on the metabolism of biogenic aldehydes in isolated human blood cells and platelets. Biochem. Pharmacol., 36(22), 3981-3985.","DOI":"10.1016\/0006-2952(87)90467-9"},{"key":"ref96","doi-asserted-by":"publisher","unstructured":"Spertini O., Hauert J., Bachmann F. (1992) Reaction of acetaldehyde with human platelets. Thromb. Haemost., 67(1), 126-130.","DOI":"10.1055\/s-0038-1648393"},{"key":"ref97","doi-asserted-by":"publisher","unstructured":"Chen Y., Davis-Gorman G., Watson R.R., McDonagh P.F. (2003) Platelet CD62p expression and microparticle formation in murine acquired immune deficiency syndrome and chronic ethanol consumption. Alcohol Alcoholism, 38(1), 25-30.","DOI":"10.1093\/alcalc\/agg013"},{"key":"ref98","doi-asserted-by":"publisher","unstructured":"Sherif F.M. (1994) GABA-Transaminase in brain and blood platelets: Basic and clinical aspects. Prog. Neuropsychopharmacol. Biol. Psychiatry, 18(8), 1219-1233.","DOI":"10.1016\/0278-5846(94)90089-2"},{"key":"ref99","doi-asserted-by":"publisher","unstructured":"White K., Shih J., Fong T. et al. (1980) Elevated platelet monoamine oxidase activity in patients with nonendogenous depression. Am. J. Psychiatry, 137(10), 1258-1259.","DOI":"10.1176\/ajp.137.10.1258"},{"key":"ref100","doi-asserted-by":"publisher","unstructured":"Wargelius H.L., Fahlke C., Suomi S.J. et al. (2010) Platelet monoamine oxidase activity predicts alcohol sensitivity and voluntary alcohol intake in rhesus monkeys. Upsala J. Med. 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