{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:53:34Z","timestamp":1780383214370,"version":"3.54.1"},"reference-count":31,"publisher":"Institute of Biochemistry","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIOMED KHIM"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Temporary cessation or restriction of breastfeeding can lead to metabolic disorders in adulthood. However,  data on the effect of fasting in the early postnatal period on the functions of the endocrine system in adulthood are rare  and contradictory. Approaches for the correction of metabolic and hormonal disorders caused by premature cessation  of breastfeeding have not been developed yet. The aim of the work was to study the metabolic and hormonal parameters  and changes in the hormonal status of the gonadal and thyroid systems in 10-month-old male rats with interruption  of breastfeeding on days P19-P21, as well as to evaluate the restorative effect on them of four weeks of treatment  with intranasal insulin (II) administered in the postnatal period (P28-P55) or in adulthood (P183-P210). Lactation  interruption has been induced by treatment of lactating females with bromocriptine (10 mg\/day\/rat, P19-P21).  Male rats with temporary cessation of breastfeeding developed characteristic signs of the metabolic syndrome  (obesity, dyslipidemia, impaired glucose tolerance, hyperleptinemia), decreased levels of testosterone and thyroid  hormones (fT4, tT3) and weakened the synthesis of testosterone and thyroxine, stimulated respectively by GnRH and  thyroliberin. This was due to a decrease in the sensitivity of the testes to luteinizing hormone (LH) and the thyroid gland  to thyroid-stimulating hormone (TSH). Treatment with II in early ontogenesis reduced body weight and fat, improved  lipid profile, sensitivity to insulin, leptin, LH and TSH, restored the levels of testosterone and thyroid hormones and  their stimulation by releasing factors. Treatment with II in adulthood normalized the levels of testosterone, thyroid  hormones, their stimulation by releasing factors, but had a little effect on metabolic and hormonal parameters.  The obtained data point to a wide range of metabolic and hormonal disorders in adult male rats with the \u201cneonatal\u201d model  of metabolic syndrome and to the effectiveness of various strategies for their correction using long-term II treatment.<\/jats:p>","DOI":"10.18097\/pbmc20226804263","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T13:05:02Z","timestamp":1661432702000},"page":"263-271","source":"Crossref","is-referenced-by-count":5,"title":["Influence of intranasally administered insulin on metabolic and hormonal parameters in adult male rats, impaired due to three-day fasting in the early postnatal period"],"prefix":"10.18097","volume":"68","author":[{"given":"K.V.","family":"Derkach","sequence":"first","affiliation":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.M.","family":"Bondareva","sequence":"additional","affiliation":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.O.","family":"Shpakov","sequence":"additional","affiliation":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint-Petersburg, Russia; Faculty of Medicine, Saint Petersburg State University, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7443","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Smith C.J., Ryckman K.K. 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