{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:05:48Z","timestamp":1794323148720,"version":"4.9.0"},"reference-count":0,"publisher":"European Society of Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRAJ"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Neonatal lung injury is a leading contributor to morbidity and long-term respiratory complications among preterm infants, and remains a persistent challenge in neonatology (O\u2019Reilly 6). Among the most common outcomes of neonatal lung injury is bronchopulmonary dysplasia (BPD), a disease hallmarked by disrupted alveolar development, inflammation, and fibrosis (O\u2019Reilly 6; Borzone 7). Over the past two decades, substantial progress has been made in unraveling the cellular and molecular underpinnings of BPD, particularly the role of alveolar epithelial cells in coordinating repair and regeneration (McGowan 5; Chapman 4). This review focuses on the emerging role of CCN5, a matricellular protein, as a regulator of epithelial cell plasticity during lung injury and repair (Bhandari 8; Fiaturi 1). We synthesize key findings from our own research and integrate them with the broader scientific literature, exploring how epithelial biology, extracellular matrix remodeling, and molecular signaling converge to influence neonatal lung outcomes. The review also highlights recent experimental insights, existing knowledge gaps, and promising therapeutic directions, with the goal of advancing translational strategies for mitigating neonatal lung injury.<\/jats:p>","DOI":"10.18103\/mra.v13i10.6931","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T18:05:20Z","timestamp":1762020320000},"source":"Crossref","is-referenced-by-count":0,"title":["Matricellular Regulation of Alveolar Epithelial Cell Plasticity in Neonatal Lung Injury: Insights from CCN5 and Beyond"],"prefix":"10.18103","volume":"13","author":[{"given":"Najla","family":"Fiaturi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7483","published-online":{"date-parts":[[2025]]},"container-title":["Medical Research Archives"],"original-title":[],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T18:05:24Z","timestamp":1762020324000},"score":1,"resource":{"primary":{"URL":"https:\/\/esmed.org\/MRA\/mra\/article\/view\/6931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18103\/mra.v13i10.6931","relation":{},"ISSN":["2375-1916","2375-1924"],"issn-type":[{"value":"2375-1916","type":"print"},{"value":"2375-1924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}