{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:50:01Z","timestamp":1792162201022,"version":"4.4.0"},"reference-count":0,"publisher":"Knowledge Enterprise Journals","issue":"8","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRAJ"],"abstract":"<jats:p>Despite decades of research, survival rates following cardiac arrest remain dismal. The recent use of pressure-volume (PV) loop analysis has provided important insights into the underlying physiology of cardiopulmonary resuscitation (CPR). During conventional CPR (C-CPR), ventricular ejection is limited, contributing to poor circulatory effectiveness. In contrast, automated head-up CPR (AHUP-CPR)\u2014which combines active compression-decompression (ACD) CPR, an impedance threshold device (ITD), and controlled head-thorax elevation\u2014generates favorable negative intrathoracic pressure, promoting cerebral venous drainage and increases right heart preload, resulting in enhanced stroke volume, cardiac output, and end-tidal CO\u2082 (ETCO\u2082) by improving ventricular\u2013pulmonary\u2013arterial circulation. This article summarizes recent advances related to AHUP-CPR with a focus on novel physiological findings derived from intraventricular conductance catheter recordings during ventricular fibrillation, C-CPR, and AHUP-CPR. The PV loop observations shed new light on the mechanisms through which AHUP-CPR improves circulatory efficiency and neurological outcomes.<\/jats:p>","DOI":"10.18103\/mra.v13i8.6907","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:17:11Z","timestamp":1756991831000},"source":"Crossref","is-referenced-by-count":0,"title":["Head Up Cardiopulmonary Resuscitation: Novel Physiological Discoveries and Latest Clinical Outcomes"],"prefix":"10.18103","volume":"13","author":[{"given":"Pouria","family":"Pourzand","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Lehigh Valley Health Network, Bethlehem, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Lurie","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7483","published-online":{"date-parts":[[2025,9,1]]},"container-title":["Medical Research Archives"],"original-title":[],"link":[{"URL":"https:\/\/esmed.org\/MRA\/mra\/article\/download\/6907\/99193549539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esmed.org\/MRA\/mra\/article\/download\/6907\/99193549539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:26:00Z","timestamp":1792160760000},"score":1,"resource":{"primary":{"URL":"https:\/\/esmed.org\/MRA\/mra\/article\/view\/6907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.18103\/mra.v13i8.6907","relation":{},"ISSN":["2375-1924","2375-1916"],"issn-type":[{"value":"2375-1924","type":"electronic"},{"value":"2375-1916","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}