{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:29:36Z","timestamp":1791473376298,"version":"4.3.4"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"published-print":{"date-parts":[[2021,10,22]]},"abstract":"<jats:p>Background: Asthma is associated with low-grade systemic inflammation, prothrombotic state, and premature atherosclerosis. Objective: To evaluate the relationships between asthma, inflammatory biomarkers, and parameters of endothelial dysfunction. Material and Methods: We analyzed flow-mediated dilatation (FMD) of the brachial artery and intima-media thickness (IMT) of the common carotid artery using ultrasound in 92 clinically stable adult asthmatics and 62 well-matched controls. We also measured blood levels of selected inflammatory and asthma-specific biomarkers, including interleukin (IL) 4, IL-5, IL-6, IL-10, IL-12 (p70), IL-17A, IL-23, and interferon \u03b3, as well as a disintegrin and metalloproteinase domain\u2013containing protein 33 (ADAM-33). In addition, we assessed endothelial damage using 2 laboratory biomarkers: circulating von Willebrand factor (vWF) and pentraxin-3. We analyzed relationships between the study variables and asthma severity, lung function abnormalities, airway remodeling indices on computed tomography, and transthoracic echocardiography parameters. Results: Asthmatics had higher IL-6, IL-10, and ADAM-33 levels. They were also characterized by 23% lower FMD% and 15% thicker IMT, as compared with controls (P&lt;.001, both). In asthma, vWF was related to age (\u00df=0.28 [95%CI, 0.15-0.41]) and remained inversely associated with FEV1 (\u00df=\u20130.2 [95%CI, \u20130.05 to \u20130.35]). Surprisingly, a negative correlation was revealed between vWF and pentraxin-3 (\u00df=\u20130.17 [95%CI, \u20130.3 to \u20130.04]). Pentraxin-3 remained positively associated with airway remodeling indices. Conclusions: Asthma is characterized by endothelial dysfunction associated with airway obstruction. The biological role of pentraxin-3 is unknown, although our data suggest a protective role against endothelial damage and atherosclerosis.<\/jats:p>","DOI":"10.18176\/jiaci.0563","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T06:14:32Z","timestamp":1588745672000},"page":"417-425","source":"Crossref","is-referenced-by-count":16,"title":["Endothelial Dysfunction and Pentraxin-3 in Clinically Stable Adult Asthma Patients"],"prefix":"10.18176","volume":"31","author":[{"given":"R","family":"Pacholczak-Madej","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Kuszmiersz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Iwaniec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zar\u0119ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zarychta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JA","family":"Walocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dropi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bazan-Socha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7491","published-online":{"date-parts":[[2021,10,25]]},"container-title":["Journal of Investigational Allergy and Clinical Immunology"],"original-title":[],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T08:14:43Z","timestamp":1635236083000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jiaci.org\/summary\/vol31-issue5-num2348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,10,25]]},"published-print":{"date-parts":[[2021,10,22]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.0563","relation":{},"ISSN":["1018-9068"],"issn-type":[{"value":"1018-9068","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,22]]}}}