{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:25:15Z","timestamp":1787023515253,"version":"build-2736575974"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"published-print":{"date-parts":[[2023,12,11]]},"abstract":"<jats:p>Background: Positive bronchodilator reversibility (BDR) is a diagnostic criterion for asthma. However, patients with asthma may exhibit a negative BDR response. Aim: To describe the frequency of positive and negative BDR response in patients with severe asthma and study associations with phenotypic characteristics. Methods: A positive BDR response was defined as an increase in FEV1 &gt;200 mL and &gt;12% upon testing with a short-acting \u00df-agonist. Results: BDR data were available for 793 of the 2013 patients included in the German Asthma Net (GAN) severe asthma registry. Of these, 250 (31.5%) had a positive BDR response and 543 (68.5%) a negative BDR response. Comorbidities significantly associated with a negative response were gastroesophageal reflux disease (GERD) (28.0% vs 40.0%, P&lt;.01) and eosinophilic granulomatosis with polyangiitis (0.4% vs 3.0%; P&lt;.05), while smoking history (active: 2.8% vs 2.2%; ex: 40.0% vs 41.7%) and comorbid chronic obstructive pulmonary disease (COPD) (5.2% vs 7.2%) were similar in both groups. Patients with a positive BDR response had worse asthma control (median Asthma Control Questionnaire 5 score, 3.4 vs 3.0, P&lt;.05), more frequently reported dyspnea at rest (26.8% vs 16.4%, P&lt;.001) and chest tightness (36.4% vs 26.2%, P&lt;.001), and had more severe airway obstruction at baseline (FEV1% predicted, 56 vs 64, P&lt;.001) and higher fractional exhaled nitric oxide (FeNO) levels (41 vs 33 ppb, P&lt;0.05). There were no differences in diffusion capacity of the lung for carbon monoxide, single breath (% pred, 70% vs 71%). Multivariate linear regression analysis identified an association between positive BDR response and lower baseline FEV1% (P&lt;.001) and chest tightness (P&lt;.05) and a negative association between BDR and GERD (P&lt;.05). Conclusion: In this real-life setting, most patients with severe asthma had a negative BDR response. Interestingly, this was not associated with smoking history or COPD, but with lower FeNO and presence of GERD.<\/jats:p>","DOI":"10.18176\/jiaci.0850","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:19:55Z","timestamp":1661329195000},"page":"445-456","source":"Crossref","is-referenced-by-count":11,"title":["Bronchodilator Reversibility in the GAN Severe Asthma Cohort"],"prefix":"10.18176","volume":"33","author":[{"given":"K","family":"Milger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Skowasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hamelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"M\u00fcmmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Idzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Gappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"K\u00f6rner-Rettberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Ehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Taube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Holtdirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Timmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Buhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Korn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7491","published-online":{"date-parts":[[2023,12,13]]},"container-title":["Journal of Investigational Allergy and Clinical Immunology"],"original-title":["English"],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T10:58:21Z","timestamp":1702551501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jiaci.org\/summary\/vol33-issue6-num2795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,11]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,13]]},"published-print":{"date-parts":[[2023,12,11]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.0850","relation":{},"ISSN":["1018-9068"],"issn-type":[{"value":"1018-9068","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,11]]}}}