{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:25:41Z","timestamp":1762093541858,"version":"build-2065373602"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"published-print":{"date-parts":[[2024,12,9]]},"abstract":"<jats:p>Background: Patients sensitized to lipid transfer protein (LTP) are characterized by wide clinical variability. The lack of practical diagnostic and therapeutic guidelines complicates their management.\nObjective: The aim of the study was to describe the clinical approach of Spanish allergists to sensitization to LTP.\nMethods: We used a survey designed following the PICO method and subsequent validation using the Delphi approach.\nResults: The survey was completed by 224 allergists (75% women; 57.1% with &gt;20 years of professional experience). Clinical practice for the main points of diagnosis of LTP allergy was homogeneous, except for patients with suspected hypersensitivity to nonsteroidal anti-inflammatory drugs (44.6% frequently included skin testing with LTP). Oral food challenges were not frequently performed (63.6% occasionally to never) and were generally (75.5%) used to confirm tolerance. It was common to recommend fruit skin avoidance (77.2%) and to maintain consumption of foods to which patients were sensitized but tolerant (99.1%). The results were heterogeneous for other dietary indications, modifications due to cofactors, and trace avoidance. Peach sublingual immunotherapy (SLIT) was considered very\/quite effective by 55.9% of allergists. Most (79.5%) consider SLIT indicated in &lt;25% of LTP-allergic patients based on severity (95.2%), frequency of reactions (99.4%), allergy to multiple food families (97.4%), and impairment of quality of life\/nutrition (91.5%). Practice with respect to prescription of SLIT varied based on cofactor involvement.\nConclusions: These data suggest that there is a need to increase evidence to reduce heterogeneity in the clinical management of LTP allergy.<\/jats:p>","DOI":"10.18176\/jiaci.0947","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T14:17:36Z","timestamp":1697552256000},"page":"395-403","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Management of Plant Food Allergy in Patients Sensitized to Lipid Transfer Proteins Is Heterogeneous: Identifying the Gaps"],"prefix":"10.18176","volume":"34","author":[{"given":"BE","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MB","family":"Mateo-Borrega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CM","family":"D'Amelio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Comp\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Villareal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Garc\u00eda-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MJ","family":"Goikoetxea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7491","published-online":{"date-parts":[[2024,12,10]]},"container-title":["Journal of Investigational Allergy and Clinical Immunology"],"original-title":["english"],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T11:12:29Z","timestamp":1733829149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jiaci.org\/summary\/vol34-issue6-num2973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,12,10]]},"published-print":{"date-parts":[[2024,12,9]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.0947","relation":{},"ISSN":["1018-9068"],"issn-type":[{"type":"print","value":"1018-9068"}],"subject":[],"published":{"date-parts":[[2024,12,9]]}}}