{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:44:34Z","timestamp":1790635474247,"version":"4.1.0"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"published-print":{"date-parts":[[2025,4,16]]},"abstract":"<jats:p>Objective: To analyze sensitization to Dermatophagoides pteronyssinus and to investigate the association between diagnostic findings and clinical severity in 218 allergic patients from 2 continents.\nMethods: Mite-allergic patients were recruited by allergology departments in Latin America (n=88: Colombia, Costa Rica, and Guatemala) and Spain (n=130). All patients had allergic rhinitis with or without asthma and positive skin prick test results to D pteronyssinus. Specific IgE levels to D pteronyssinus, Dermatophagoides farinae, Der p 1, Der p 2, and Der p 23 were quantified using ImmunoCAP (Thermo Fisher Scientific). The allergenic profile was also determined by Western blotting. A comparative statistical analysis was performed using GraphPad software.\nResults: Patients most frequently recognized Der p 2 (79%), followed by Der p 1 (73%) and Der p 23 (69%). The percentage of patients with asthma increased with the number of sensitizations; however, no statistically significant differences were found. Interestingly, patients with asthma presented the highest median levels of total IgE and specific IgE for D pteronyssinus and molecular allergens, mainly Der p 2. Analysis of both populations revealed that Spanish patients were predominantly sensitized to Der p 2 (88.46%) and Der p 1 (83.84%), whereas Latin American patients were more sensitized to Der p 23.\nConclusions: Our data support the relevance of Der p 2 as the major allergen in mite allergy. A large percentage of patients are sensitized to this allergen, which plays a key role in the development of asthma. Sensitization to Der p 23 was more relevant in Latin America.<\/jats:p>","DOI":"10.18176\/jiaci.0968","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T10:38:25Z","timestamp":1704278305000},"page":"114-121","source":"Crossref","is-referenced-by-count":4,"title":["Differences in Molecular Sensitization Profiles Between Spanish and Latin American Mite-Allergic Patients"],"prefix":"10.18176","volume":"35","author":[{"given":"D","family":"Calzada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bartra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CD","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Riggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JP","family":"Maselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DL","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LF","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pascal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Carn\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7491","published-online":{"date-parts":[[2025,4,22]]},"container-title":["Journal of Investigational Allergy and Clinical Immunology"],"original-title":["english"],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T15:49:25Z","timestamp":1745336965000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jiaci.org\/summary\/vol35-issue2-num3036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4,22]]},"published-print":{"date-parts":[[2025,4,16]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.0968","relation":{},"ISSN":["1018-9068"],"issn-type":[{"value":"1018-9068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,16]]}}}