{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:33:58Z","timestamp":1789774438394,"version":"4.0.1"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"published-print":{"date-parts":[[2025,7,22]]},"abstract":"<jats:p>Background: Peanut allergy (PA) is an IgE-mediated food allergy with variable clinical outcomes. Mild-to-severe symptoms affect various\norgans and, often, the gastrointestinal tract. The role of intestine-derived IgE antibodies in gastrointestinal PA symptoms is poorly understood.\nObjective: This study aimed to examine fecal IgE responses in PA as a novel approach to patient endotyping.\nMethods: Feces and serum samples were collected from peanut-allergic and healthy children (n=26) to identify IgE and cytokines using\nmultiplex assays. Shotgun metagenomics DNA sequencing and allergen database comparisons made it possible to identify microbial\npeptides with homology to known allergens.\nResults: Compared to controls, fecal IgE signatures showed broad diversity and increased levels for 13 allergens, including food, venom,\ncontact, and respiratory allergens (P&lt;.01-.0001). Overall, fecal IgE patterns were negatively correlated compared to sera IgE patterns in PA\npatients, with the greatest differences recorded for peanut allergens (P&lt;.0001). For 83% of the allergens recognized by fecal IgE, we found\nbacterial homologs from PA patients\u2019 gut microbiome (eg, thaumatin-like protein Acinetobacter baumannii vs Act d 2, 109\/124 aa identical).\nCompared to controls, PA patients had higher levels of fecal IgA, IL-22, and auto-IgE binding to their own fecal proteins (P&lt;.001). Finally,\nlevels of fecal IgE correlated with abdominal pain scores (P&lt;.0001), suggesting a link between local IgE production and clinical outcomes.\nConclusion: Fecal IgE release from the intestinal mucosa could be an underlying mechanism of severe abdominal pain through the\nassociation between leaky gut epithelia and anticommensal TH2 responses in PA.<\/jats:p>","DOI":"10.18176\/jiaci.1008","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T06:40:34Z","timestamp":1721976034000},"page":"276-287","source":"Crossref","is-referenced-by-count":5,"title":["Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients"],"prefix":"10.18176","volume":"35","author":[{"given":"R","family":"Czolk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Codreanu-Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"de Nies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SB","family":"Busi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Halder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Hunewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TM","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FQ","family":"Hefeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"De Beaufort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Wilmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ollert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kuehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7491","published-online":{"date-parts":[[2025,7,29]]},"container-title":["Journal of Investigational Allergology and Clinical Immunology"],"original-title":["English"],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:06:57Z","timestamp":1753787217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jiaci.org\/summary\/vol35-issue4-num3101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,7,29]]},"published-print":{"date-parts":[[2025,7,22]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.1008","relation":{},"ISSN":["1018-9068"],"issn-type":[{"value":"1018-9068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,22]]}}}