{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:55:51Z","timestamp":1781607351086,"version":"3.54.5"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"published-print":{"date-parts":[[2026,6,9]]},"abstract":"<jats:p>Background: Provocation tests with contrast media are increasingly necessary to complete an allergy work-up. However, they are not standardized.\nObjective: We aimed to evaluate a rapid provocation test in patients with a history of anaphylaxis. Our secondary objectives included phenotyping the study population and proposing a predictive methodology for allergy test outcomes.\nMethods: We performed an allergy study using iohexol, iodixanol, ioversol, and iobitridol in patients \u226518 years of age with previous hypersensitivity reactions to iodinated contrast media. A rapid provocation test (100 cc administered in 12 minutes) was performed using a noninvolved iodinated contrast medium that had yielded negative skin test results. The statistical analysis comprised binary logistic regression and cluster analysis.\nResults: A total of 130 patients were enrolled. Ninety-six patients (74%) developed cutaneous symptoms exclusively, while 17 patients (13%) experienced anaphylaxis. Nine patients (7%) had positive skin test results, and 20 of 141 provocation tests performed were positive. All patients developed mild cutaneous symptoms, including those with a history of anaphylaxis. A safe alternative contrast medium was recommended to 122 patients (94%), with good tolerance in 50 patients in a new radiological examination. We identified 3 patient phenotypes, each associated with a different risk of a positive drug provocation test result. A predictive model for allergy test outcomes was developed, although its statistical predictive capacity was low.\nConclusions: We confirmed the efficacy and safety of a protocol including rapid provocation tests in patients with hypersensitivity reactions to iodinated contrast media of varying severity. Three patient clusters were identified, each showing a different risk level for a positive provocation test result.<\/jats:p>","DOI":"10.18176\/jiaci.1091","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:39:31Z","timestamp":1762421971000},"page":"226-236","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of an Allergy Study Including Rapid Provocation Tests to Identify a Safe Alternative Contrast Agent and Phenotyping of Patients With a History of Hypersensitivity to Iodinated Contrast Media"],"prefix":"10.18176","volume":"36","author":[{"given":"Francisco","family":"Vega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azahara","family":"Lopez-Raigada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Soria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Catala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Blanco-Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mugica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7491","published-online":{"date-parts":[[2026,6,16]]},"container-title":["Journal of Investigational Allergology and Clinical Immunology"],"original-title":[],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:27:18Z","timestamp":1781605638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jiaci.org\/summary\/vol36-issue3-num3284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,16]]},"published-print":{"date-parts":[[2026,6,9]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.1091","relation":{},"ISSN":["1018-9068","1698-0808"],"issn-type":[{"value":"1018-9068","type":"print"},{"value":"1698-0808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]}}}