{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:42:25Z","timestamp":1792496545593,"version":"4.5.0"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"published-print":{"date-parts":[[2026,10,19]]},"abstract":"<jats:p>Background: House dust mite (HDM) allergy is a leading cause of allergic rhinoconjunctivitis and asthma. Among the major HDM allergens, Der p 23 has been recognized as clinically relevant. However, allergen immunotherapy (AIT) extracts often lack defined amounts of Der p 23, which may compromise treatment in patients sensitized exclusively to this component.\nObjective: To determine the prevalence of monosensitization to Der p 23 among HDM-allergic patients and to assess the capacity of commercial HDM skin prick test (SPT) extracts to inhibit IgE binding.\nMethods: A retrospective analysis on 1700 HDM-allergic patients was carried out between 2019 and 2023. Specific IgE to Der p 1, 2, and 23 was measured using ImmunoCAP. Monosensitization to Der p 23 was defined as sIgE &gt;0.35 kUA\/L to Der p 23 and &lt;0.10 kUA\/L to Der p 1 and 2. Additional molecular profiling (ALEX microarray) was performed to confirm exclusive sensitization. sIgE inhibition assays were used to evaluate 5 commercial HDM extracts.\nResults: Almost two-thirds of patients (62.3%) were sensitized to Der p 23, and 3.47% (n=59) were monosensitized. Of these, 72.7% (16\/22) were confirmed by ALEX. SPT extracts inhibited IgE binding in between 42% and 77% of cases depending on the manufacturer.\nConclusions: The findings indicate that monosensitization to Der p 23, though relatively infrequent, affects a clinically relevant subset of patients. Commercial extracts vary in their ability to inhibit sIgE to Der p 23, underscoring the need for improved extract formulations and further research into the efficacy of AIT in this subgroup.<\/jats:p>","DOI":"10.18176\/jiaci.1121","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:48:53Z","timestamp":1761119333000},"page":"375-381","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Sensitization to Der p 23 and Inhibition of Specific IgE Using Commercial Extracts in House Dust Mite\u2013Allergic Patients"],"prefix":"10.18176","volume":"36","author":[{"given":"Patricia","family":"Bigas Pe\u00f1uela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Vi\u00f1as-Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s","family":"Labrador Horrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Cardona Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Tatiana","family":"Verdesoto Viteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Luengo S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7491","published-online":{"date-parts":[[2026,10,20]]},"container-title":["Journal of Investigational Allergology and Clinical Immunology"],"original-title":[],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:08:18Z","timestamp":1792494498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jiaci.org\/summary\/vol36-issue5-num3335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10,20]]},"published-print":{"date-parts":[[2026,10,19]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.1121","relation":{},"ISSN":["1018-9068","1698-0808"],"issn-type":[{"value":"1018-9068","type":"print"},{"value":"1698-0808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]}}}