{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:59:25Z","timestamp":1784829565670,"version":"3.55.0"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"abstract":"<jats:p>Background: The prevalence of eosinophilic esophagitis (EoE) continues to increase, although nearly a decade has passed since the last reported epidemiological assessment in Spain.\nObjective: To update population-based estimates of incidence, prevalence, and trends in EoE among children and adults.\nMethods: A population-based study was conducted between 2006 and 2024 in 2 Spanish EoE units. Cases were retrieved from the EoE CONNECT database; pathology databases were also consulted to ensure exhaustive data inclusion. Diagnosis of EoE was confirmed with symptoms of esophageal dysfunction and eosinophilia \u226515\/HPF. Annual incidence rates and prevalence with 95%CIs were standardized to each area population.\nResults: A total of 563 patients were treated during 2006-2024 (243 at Tomelloso General Hospital [50 children] and 320 at Hospital Universitario de Caceres). The average incidence in children was 15.74 (95%CI, 11.3-20.3) new cases\/100 000 inhabitants\/year for the whole study period, peaking at 23.95 (95%CI, 16.9-32.5) during the last decade. The prevalence of pediatric EoE in 2024 was 143.6 (95%CI, 88.1-215.4)\/100 000 inhabitants. The average incidence for adults at Tomelloso for the whole period was 11.49 (95%CI, 9.9-13.2) new cases\/100 000 inhabitants\/year, with prevalence in 2024 reaching 251.39 (95%CI, 219.3-287.1) cases\/100 000 inhabitants. The incidence in Caceres was 9.41 (95%CI, 8.3-10.5)\/100 000 inhabitants, increasing markedly throughout the period, with prevalence in 2024 at 194.73 (95%CI, 175-216.8) cases\/100 000 inhabitants. All prevalence figures doubled prior estimates from 2016-2017.\nConclusion: EoE is growing sharply and steadily and is increasingly considered a chronic disorder. Its prevalence has doubled in both children and adults in less than a decade in Spain.<\/jats:p>","DOI":"10.18176\/jiaci.1161","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:11:12Z","timestamp":1774876272000},"source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of Eosinophilic Esophagitis Doubles in Less Than a Decade: A Population-Based Study in 2 Regions of Spain"],"prefix":"10.18176","volume":"37","author":[{"given":"\u00c1ngel","family":"Arias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cabrera-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"\u00dabeda-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulianni","family":"Jim\u00e9nez-Colmen\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Dom\u00ednguez-Humanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Guti\u00e9rrez-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Ju\u00e1rez-Tosina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Molina-Infante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Lucendo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7491","published-online":{"date-parts":[[2026,3,30]]},"container-title":["Journal of Investigational Allergology and Clinical Immunology"],"original-title":[],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:11:13Z","timestamp":1774876273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jiaci.org\/ahead-of-print\/prevalence-of-eosinophilic-esophagitis-doubles-in-less-than-a-decade--a-population-based-study-in-2-regions-of-spain"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,30]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.1161","relation":{},"ISSN":["1018-9068","1698-0808"],"issn-type":[{"value":"1018-9068","type":"print"},{"value":"1698-0808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}