{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:37:05Z","timestamp":1788518225994,"version":"build-2803163510"},"reference-count":0,"publisher":"Esmon Publicidad, SA","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Investig Allergol Clin Immunol"],"published-print":{"date-parts":[[2026,6,9]]},"abstract":"<jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with a high incidence of postoperative recurrence despite medical and surgical treatments. However, a universal definition of recurrence and its determinants is lacking. Our objective was to establish a clear definition of recurrence and reach consensus on the contributing factors. A consensus study was conducted using the Delphi method. The literature on recurrence of CRSwNP was reviewed and assessed by a multidisciplinary scientific committee. The committee designed a 2-round online Delphi questionnaire addressing recurrence in CRSwNP. As for consensus, \u226570% of panelists scored 1-3 (disagreement) or 7-9 (agreement). The survey involved 70 physicians (69 completed both rounds) with expertise in the management of CRSwNP (47 ear, nose, and throat [ENT] specialists and 22 allergists). Consensus was reached on the characteristics defining recurrence (87% overall agreement, 95% agreement among allergists, and 83% agreement among ENT specialists). Finally, a list of 10 key prognostic factors was agreed upon. The top 5 were presence of nonsteroidal anti-inflammatory drug\u2013exacerbated respiratory disease, eosinophilic CRSwNP, asthma, extent of surgery, and eosinophils in nasal polyposis (&gt;50\/high-power field). This study identified 10 key prognostic factors for recurrence and clarified the definition of recurrence in CRSwNP as the reappearance or worsening of sinonasal symptoms (&gt;3 points on a visual analog scale and\/or \u226512 points in the 22-item Sino-Nasal Outcome Test) and\/or objective evidence of inflammation (nasal polyposis grade \u22651 or other endoscopic or radiological signs of persistent mucosal inflammation) after initial postoperative improvement (baseline postoperative assessment 1 month after surgery, recurrence evaluated 6 months thereafter), excluding persistence and suboptimal surgical outcome.<\/jats:p>","DOI":"10.18176\/jiaci.1176","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:55:26Z","timestamp":1777452926000},"page":"198-206","source":"Crossref","is-referenced-by-count":1,"title":["Consensus Review: Predicting Recurrence in Chronic Rhinosinusitis With Nasal Polyps: Multidisciplinary Insights From the RELAPSE Project"],"prefix":"10.18176","volume":"36","author":[{"given":"Isam","family":"Alobid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Sandra","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Calvo-Henriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Col\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Fern\u00e1ndez-Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruperto","family":"Gonz\u00e1lez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7491","published-online":{"date-parts":[[2026,6,16]]},"container-title":["Journal of Investigational Allergology and Clinical Immunology"],"original-title":[],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:27:17Z","timestamp":1781605637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jiaci.org\/summary\/vol36-issue3-num3281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,16]]},"published-print":{"date-parts":[[2026,6,9]]}},"URL":"https:\/\/doi.org\/10.18176\/jiaci.1176","relation":{},"ISSN":["1018-9068","1698-0808"],"issn-type":[{"value":"1018-9068","type":"print"},{"value":"1698-0808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]}}}