{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T18:24:40Z","timestamp":1771525480016,"version":"3.50.1"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2021,3,18]]},"abstract":"<jats:p>AIM: To evaluate the two-year outcomes of patients treated for diabetic macular edema (DME) with intravitreal Conbercept (IVC).\nMETHODS: The clinical data of 30 DME patients (36 eyes) were retrospectively reviewed. The patients were treated with IVC for 3mo. Additional IVC was given at subsequent monthly visits, if needed (3+PRN). The patients were followed up for 24mo.\nRESULTS: The best-corrected visual acuity (BCVA) at 24mo significantly increased (66.7\u00b115.3 letters) in comparison with the baseline (54.4\u00b115.4 letters, P&lt;0.0001). The mean improvement in BCVA was 11.0\u00b12.9 letters. At 24mo, 44.1% of the eyes surveyed gained \u226515 letters, 52.9% of the eyes gained \u226510 letters, and 70.6% of the eyes gained \u22655 letters. No vision loss was noted in 96.8% of the eyes, and 5.9% of the eyes lost \u22655 letters, but \u226410 letters. The central retinal thickness (CRT) at 24mo was significantly reduced (277.1\u00b1122.9 \u03bcm) in comparison with the baseline (510.9\u00b1186.1 \u03bcm, P&lt;0.0001). At 24mo, 43.3% of the patients had a CRT \u2264250 \u03bcm. The mean number of injections over 24mo was 10.6\u00b12.0. No severe eye or systemic adverse events related to either the drug or injection were noted.\nCONCLUSION: IVC is safe and effective for the treatment of DME.<\/jats:p>","DOI":"10.18240\/ijo.2021.03.14","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T01:35:38Z","timestamp":1614476138000},"page":"416-422","source":"Crossref","is-referenced-by-count":9,"title":["Real-world outcomes of two-year Conbercept therapy for diabetic macular edema"],"prefix":"10.18240","volume":"14","author":[{"name":"Department of Ophthalmology, People&#x2019;s Hospital, Peking University, Beijing 100044, China; Eye Diseases and Optometry Institute, College of Optometry, Peking University Health Science Center, Beijing 100044, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, China","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, People&#x2019;s Hospital, Peking University, Beijing 100044, China; Eye Diseases and Optometry Institute, College of Optometry, Peking University Health Science Center, Beijing 100044, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, People&#x2019;s Hospital, Peking University, Beijing 100044, China; Eye Diseases and Optometry Institute, College of Optometry, Peking University Health Science Center, Beijing 100044, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2021\/3\/20210314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T01:35:54Z","timestamp":1614476154000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20210314&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2021.03.14","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]}}}