{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:24:48Z","timestamp":1777289088629,"version":"3.51.4"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2022,5,18]]},"abstract":"<jats:p>AIM: To investigate effects of anti-TNF biologic drugs on uveitis severity (comparing visual acuity logMAR levels) in Beh\u00e7et patients.\nMETHODS: Three databases PubMed, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-\u03b1 factors treatment in Beh\u00e7et\u2019s disease (BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted.\nRESULTS: The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis (with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies (28.56 and 7.56 mg\/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity logMAR levels (MD=-1.5 IU\/L, 95%CI: -2.1, -0.01).\nCONCLUSION: Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.<\/jats:p>","DOI":"10.18240\/ijo.2022.05.19","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T08:40:04Z","timestamp":1651048804000},"page":"813-819","source":"Crossref","is-referenced-by-count":11,"title":["Effects of anti-TNF biologic drugs on uveitis severity in Behcet patients: systematic review and Meta-analysis"],"prefix":"10.18240","volume":"15","author":[{"name":"Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5756115111, Iran; Student Research Committee, Urmia University of Medical Sciences, Urmia 5756115111, Iran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Abolhasani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foroogh","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614766, Iran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva Gholizadeh-Ghaleh","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5756115111, Iran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahriar","family":"Alipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5756115111, Iran; Student Research Committee, Urmia University of Medical Sciences, Urmia 5756115111, Iran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2022\/5\/20220519.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T08:40:29Z","timestamp":1651048829000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20220519&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,18]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2022.05.19","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,18]]}}}