{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:33:00Z","timestamp":1777901580735,"version":"3.51.4"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2023,2,18]]},"abstract":"<jats:p>AIM: To assess the efficacy of ketotifen in treating allergic conjunctivitis.\nMETHODS: A systematic search of systematic reviews and Meta-analyses was conducted on the PubMed and Web Science of Science until October 2021 to address this knowledge gap. Mean difference with 95%CI and P values were used to assess the efficacy of ketotifen. The heterogeneity (I2) was used to evaluate the impact of heterogeneity.\nRESULTS: Eight randomized controlled trials (RCTs) involving 1589 patients were included in this Meta-analysis. The results revealed that after treating with ketotifen, itching (MD=-0.91, 95%CI: -1.63 to -0.20, I2=94%, P=0.01), tearing (MD=-0.40, 95%CI: -0.61 to -0.18, I2=75%, P=0.0003) and total signs and symptoms (MD=-0.85, 95%CI: -1.12 to -0.58, I2=0, P&lt;0.00001) showed better benefit effect compared to the placebo group.\nCONCLUSION: Topical ketotifen is an effective treatment for patients with allergic conjunctivitis.<\/jats:p>","DOI":"10.18240\/ijo.2023.02.17","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T22:11:27Z","timestamp":1675375887000},"page":"286-292","source":"Crossref","is-referenced-by-count":5,"title":["Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis"],"prefix":"10.18240","volume":"16","author":[{"name":"Department of Ophthalmology, Shanghai Wusong Central Hospital, Shanghai 200940, China","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yan","family":"Dou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2023\/2\/20230217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T22:11:56Z","timestamp":1675375916000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20230217&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,18]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2023.02.17","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,18]]}}}