{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:35:45Z","timestamp":1781879745733,"version":"3.54.5"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:p>AIM: To explore the effect of orthokeratology (OK) fitting on retinal vessel density in low to moderate myopia adolescents by using optical coherence tomography angiography.\nMETHODS: Children aged 10 to 14y with a cycloplegic spherical equivalent refraction of \u22120.50 diopter (D) to \u22125.00 D and astigmatism with more than \u22121.50 D were recruited. The enrolled adolescents were divided into OK group and spectacle group. During regular follow-up, adolescents were measured respectively at pre-wear, 1, 3, and 6mo after treatment. The follow-up included uncorrected distance visual acuity (UDVA), axial length (AL), superficial capillary plexus density (SCPD), deep capillary plexus density (DCPD), central retinal thickness (CRT), foveal avascular zone area (FAZ-A), foveal avascular zone perimeter (FAZ-P) and foveal vessel density in a 300-\u00b5m-wide region around foveal avascular zone (FD-300). The collected data were analyzed using statistical methods.\nRESULTS: By one month, SCPD significantly increased in the fovea and superior retina, and DCPD significantly increased inferiorly in OK group compared to spectacle group (P&amp;#x003C;0.05). By three months, there were significant increases in SCPD in the fovea and inferior retina, and DCPD in the parafovea, superior, and inferior retina in OK group (P&amp;#x003C;0.05), while the increase in SCPD and DCPD in the fovea were observed by six months (P&amp;#x003C;0.05). The FD-300 significantly increased at every follow-up in OK group compared to spectacle group (P&amp;#x003C;0.05). No significant differences in the CRT, FAZ-A and FAZ-P and FD-300 were observed between two groups (P&amp;#x003E;0.05). OK group showed a significant improvement in UDVA after wearing OK, compared to spectacle group (P&amp;#x003C;0.01), while the AL did not show a significant difference between two groups (P&amp;#x003E;0.05).\nCONCLUSION: Short-term OK worn can increase local retinal vessel density in adolescents with low-to-moderate myopia.<\/jats:p>","DOI":"10.18240\/ijo.2023.09.19","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:46:48Z","timestamp":1692679608000},"page":"1512-1520","source":"Crossref","is-referenced-by-count":6,"title":["Changes of retinal vessel density in low to moderate myopic eyes with orthokeratology evaluated by optical coherence tomography angiography"],"prefix":"10.18240","volume":"16","author":[{"name":"Medical College of Anhui University of Science and Technology, Huainan 232000, Anhui Province, China; South Hospital of the Sixth People's Hospital, Shanghai 201400, China","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hui","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"South Hospital of the Sixth People's Hospital, Shanghai 201400, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"South Hospital of the Sixth People's Hospital, Shanghai 201400, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"South Hospital of the Sixth People's Hospital, Shanghai 201400, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Cheng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"South Hospital of the Sixth People's Hospital, Shanghai 201400, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Shibei Hospital, Shanghai 200435, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2023\/9\/20230919.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:47:15Z","timestamp":1692679635000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20230919&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,18]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2023.09.19","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,18]]}}}