{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T14:12:58Z","timestamp":1724854378064},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2024,9,18]]},"abstract":"<jats:p>AIM: To investigate the effect of \u03b2-alanine (BA) on laser-induced choroidal neovascularization (CNV) mice models.\nMETHODS: Laser-induced CNV mice models were established, and BA was administrated for one week and two weeks in advance, separately. Furthermore, retinal pigment epithelium (RPE)-choroid flat mounts were separated, and immunohistochemical staining was performed. The laser-induced CNV lesion areas were measured and compared. In addition, liver and kidney morphologies were observed to identify potential hepatorenal toxicity.\nRESULTS: Enlarged CNV lesion areas were observed in the BA treated group. No significant differences were observed in the liver and kidney sections between groups.\nCONCLUSION: BA treatment increase CNV lesion areas, suggesting the detrimental effects of BA as a nutritional supplement in age-related macular degeneration (AMD) population.<\/jats:p>","DOI":"10.18240\/ijo.2024.09.03","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T07:15:29Z","timestamp":1724138129000},"page":"1592-1598","source":"Crossref","is-referenced-by-count":0,"title":["Beta-alanine promotes angiogenesis in laser-induced choroidal neovascularization mice models"],"prefix":"10.18240","volume":"17","author":[{"name":"Department of Ophthalmology, Shanghai General Hospital (Shanghai First People&#x2019;s Hospital), Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Li","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Dong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Shanghai General Hospital (Shanghai First People&#x2019;s Hospital), Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China; National Clinical Research Center for Ophthalmic Diseases, Shanghai 200080, China; National Clinical Research Center for Eye Diseases, Shanghai 200080, China; Shanghai Key Laboratory of Fundus Diseases, Shanghai 200080, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2024\/9\/20240903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T07:15:34Z","timestamp":1724138134000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20240903&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2024.09.03","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,18]]}}}