{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T03:40:37Z","timestamp":1731987637733,"version":"3.28.0"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:p>AIM: To establish an animal model of form deprivation amblyopia based on a simulated cataract intraocular lens (IOLs).\nMETHODS: Poly(dimethyl siloxane)-SiO2 thin films (PSF) with different degrees of opacity as IOL materials were prepared. The light transmission of the PSF-IOL was measured, and its in vitro biosafety was determined by cell counting kit (CCK)-8 assay using the HLEC-B3 cell line and ARPE-19 cell line. Subsequently, the in vivo safety was determined by implanting the PSF-IOL with 10% wt SiO2 into the right eyes of New Zealand white rabbits (PSF-IOL group), and compared with two control groups: contralateral comparison group and normal control (NC) group (Contralateral comparison group: the fellow eye; NC group: a group of binocular normal rabbits without intervention). The flash visual-evoked potentials (F-VEPs) were measured to verify amblyopia.\nRESULTS: PSFs containing 0, 2%, and 10% wt SiO2 were successfully constructed. The 0 SiO2 PSF was transparent, while the 10% wt SiO2 PSF was completely opaque. It was found that PSF did not induce unwanted cytotoxicity in HLECs and ARPE19 cells in vitro. In vitro, PSF-IOL with 10% wt SiO2 was also non-toxic, and no significant inflammation or structural changes occurred after four weeks of PSF-IOL implantation. Finally, our IOL-simulated congenital cataract rabbit detected by F-VEPs suggested tentative amblyopia.\nCONCLUSION: A PSF-IOL that mimics cataracts is created. A novel form deprivation model is created by the IOL-simulated congenital cataract rabbit. It can be developed fast and stable and holds great potential for future study.<\/jats:p>","DOI":"10.18240\/ijo.2024.12.04","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T03:11:37Z","timestamp":1731985897000},"page":"2177-2184","source":"Crossref","is-referenced-by-count":0,"title":["Modeling monocular form deprivation in rabbits using a simulated-cataract intraocular lens"],"prefix":"10.18240","volume":"17","author":[{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325003, Zhejiang Province, China; The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou 325003, Zhejiang Province, China; National Center for Clinical and Medical Research, Wenzhou 325003, Zhejiang Province, China","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Yi","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325003, Zhejiang Province, China; The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou 325003, Zhejiang Province, China; National Center for Clinical and Medical Research, Wenzhou 325003, Zhejiang Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Li","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325003, Zhejiang Province, China; The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou 325003, Zhejiang Province, China; National Center for Clinical and Medical Research, Wenzhou 325003, Zhejiang Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325003, Zhejiang Province, China; 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The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou 325003, Zhejiang Province, China; National Center for Clinical and Medical Research, Wenzhou 325003, Zhejiang Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325003, Zhejiang Province, China; The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou 325003, Zhejiang Province, China; National Center for Clinical and Medical Research, Wenzhou 325003, Zhejiang Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Jun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325003, Zhejiang Province, China; The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou 325003, Zhejiang Province, China; National Center for Clinical and Medical Research, Wenzhou 325003, Zhejiang Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-E","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325003, Zhejiang Province, China; The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou 325003, Zhejiang Province, China; National Center for Clinical and Medical Research, Wenzhou 325003, Zhejiang Province, China; Eye Hospital of Wenzhou Medical University at Hangzhou, Hangzhou 310000, Zhejiang Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2024\/12\/20241204.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T03:11:42Z","timestamp":1731985902000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20241204&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2024.12.04","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]}}}