{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T05:13:55Z","timestamp":1737090835643,"version":"3.33.0"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:p>AIM: To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage (DVH) and its correlation with clinical characteristics.\nMETHODS: Twenty-one individuals with DVH (male\/female 12\/9; mean age 52.29\u00b111.66y) were selected, alongside 21 appropriately matched controls with diabetes mellitus (DM). Voxel-based morphometry (VBM) techniques were employed to identify aberrant functional regions in the brain. Receiver operating characteristic (ROC) curves were utilized for classification based on the average VBM values of the two groups, and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical manifestations.\nRESULTS: Relative to the DM controls, DVH patients exhibited reduced VBM values in the right superior temporal pole, the right superior temporal gyrus, the right medial orbital frontal gyrus, and the left superior frontal gyrus. Furthermore, ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy, as indicated by the area under the curve. The average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale (HADS).\nCONCLUSION: Pathological alterations in four distinct brain regions are observed in patients with DVH, potentially reflecting neuropathological changes associated with this condition.<\/jats:p>","DOI":"10.18240\/ijo.2025.02.09","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:56:41Z","timestamp":1737014201000},"page":"258-267","source":"Crossref","is-referenced-by-count":0,"title":["Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry"],"prefix":"10.18240","volume":"18","author":[{"name":"Department of Ophthalmology, Dahua Hospital, Shanghai 200237, China","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jun","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Mei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Qi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Ophthalmology Centre of Maastricht University, Maastricht 6200MS, Limburg Provincie, the Netherlands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"School of optometry and vision science, Cardiff University, Cardiff, CF24 4HQ, Wales, UK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200080, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2025\/2\/20250209.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:56:48Z","timestamp":1737014208000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20250209&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2025.02.09","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}