{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:51:39Z","timestamp":1775155899841,"version":"3.50.1"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:p>AIM: To determine the risk factors and time to non-arteric ischemic optic neuropathy (NAION) occurrence among Thai type 2 diabetes mellitus (T2DM) patients.\nMETHODS: A retrospective review of 266 newly diagnosed T2DM cases at Rajavithi Hospital between 2007 and 2016 was conducted to determine time to occurrence of NAION and evaluate associated risk factors.\nRESULTS: Hypertension and dyslipidemia were the most common pre-existing vascular diseases and there was a significant male predominance in the NAION group. The mean age of the NAION group was significantly higher than that of the group without NAION. A higher proportion of subjects in the NAION group had hypertension, dyslipidemia, high diastolic blood pressure, smokers, and had a small cup-to-disc ratio (CDR). Higher levels of triglycerides and low-density lipoprotein-cholesterol in the group with NAION. Fifty-five patients among 266 participants (20.68%) developed NAION during a mean follow-up time of 81.26\u00b125.04mo. In a multivariable logistic regression analysis, dyslipidemia (OR=8.36, 95%CI, 3.447\u201320.273, P&lt;0.001), high low density lipoprotein levels (OR=1.017, 95%CI, 1.004\u20131.029, P=0.009), and small CDR (OR=11.92, 95%CI, 4.477\u201331.741, P&lt;0.001) were significant risk factors for NAION development. Smoking was the strongest predictive risk (OR=12.843, 95%CI, 3.959\u201341.659, P&lt;0.001). Vascular complications of T2DM and aspirin were not associated with NAION.\nCONCLUSION: T2DM patients with dyslipidemia or a small CDR should be carefully followed up as they are at increased risk of developing NAION.<\/jats:p>","DOI":"10.18240\/ijo.2025.02.13","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:56:41Z","timestamp":1737014201000},"page":"290-296","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study"],"prefix":"10.18240","volume":"18","author":[{"name":"Department of Ophthalmology, Rangsit University, Rajavithi Hospital, Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parinee","family":"Kemchoknatee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thansit","family":"Srisombut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Rangsit University, Rajavithi Hospital, Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand; Faculty of Medicine, Rajavithi Hospital, Rangsit University, Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2025\/2\/20250213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:56:51Z","timestamp":1737014211000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20250213&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2025.02.13","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}