{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T05:16:05Z","timestamp":1740114965174,"version":"3.37.3"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2025,3,18]]},"abstract":"<jats:p>AIM: To investigate the refractive and the histological changes in guinea pig eyes after posterior scleral reinforcement with scleral allografts.\nMETHODS: Four-week-old guinea pigs were implanted with scleral allografts, and the changes of refraction, corneal curvature and axis length were monitored for 51d. The effects of methylprednisolone (MPS) on refraction parameters were also evaluated. And the microstructure and ultra-microstructure of eyes were observed on the 9d and 51d after operation. Repeated-measures analysis of variance and one-way analysis of variance were used.\nRESULTS: The refraction outcome of the implanted eye decreased after operation, and the refraction change of the 3 mm scleral allografts group was significantly different with control group (P=0.005) and the sham surgical group (P=0.004). After the application of MPS solution, the reduction of refraction outcome was statistically suppressed (P=0.008). The inflammatory encapsulation appeared 9d after surgery. On 51d after operation, the loose implanted materials were absorbed, while the adherent implanted materials with MPS group were still tightly attached to the recipient\u2019s eyeball.\nCONCLUSION: After implantation of scleral allografts, the refraction of guinea pig eyes fluctuated from a decrease to an increase. The outcome of the scleral allografts is affected by implantation methods and the inflammatory response. Stability of the material can be improved by MPS.<\/jats:p>","DOI":"10.18240\/ijo.2025.03.01","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T07:52:31Z","timestamp":1740037951000},"page":"375-382","source":"Crossref","is-referenced-by-count":0,"title":["Refractive status and histological changes after posterior scleral reinforcement in guinea pig"],"prefix":"10.18240","volume":"18","author":[{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Yan","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; Hefei Aier Eye Hospital, Hefei 230000, Anhui Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215000, Jiangsu Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao-Zhen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; Department of Ophthalmology, Shanghai Ninth People&#x2019;s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2025\/3\/20250301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T07:52:32Z","timestamp":1740037952000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20250301&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2025.03.01","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]}}}