{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:14:58Z","timestamp":1787962498233,"version":"build-2784847793"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2025,3,18]]},"abstract":"<jats:p>AIM: To assess the relationship between serological parameters and the prognosis of young patients with retinal vein occlusion (RVO) after intravitreal conbercept injection (IVC).\nMETHODS: This study enrolled 100 young patients (\u226450 years old) diagnosed with RVO-related macular edema (RVO-ME) who had been undergoing IVC at the 474 Hospital in Xinjiang between January 2022 and October 2023. Patients were categorized into two groups: 70 eyes in the effective group and 30 eyes in the ineffective group. The effective group comprised patients exhibiting a visual acuity improvement of \u22652 lines at the last follow-up, with resolved ME and central macular thickness (CMT) &lt;300 \u03bcm. Conversely, the ineffective group included patients with visual acuity improvement of &lt;1 line, persistent ME, and CMT \u2265300 \u03bcm at the last follow-up. Serological parameters, including white blood cell count, neutrophil count, lymphocyte count, monocyte count, and mean platelet volume were assessed before treatment. The correlation between best-corrected visual acuity (BCVA) and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and systemic immune response index (SIRI) was analyzed. Additionally, the association between these serological parameters and the efficacy of IVC was explored.\nRESULTS: Three months after treatment, the effective group demonstrated a significant improvement in BCVA from 0.82\u00b10.20 to 0.36\u00b10.10, with a concurrent decrease in CMT from 661.28\u00b1163.90 to 200.61\u00b182.45 \u03bcm (P&lt;0.001). Conversely, the ineffective group exhibited minimal changes in BCVA (0.86\u00b10.25 to 0.82\u00b10.14) and CMT (669.84\u00b1164.95 to 492.13\u00b1138.67 \u03bcm, P&lt;0.001). The differences in BCVA and CMT between the two groups were statistically significant (P&lt;0.001). According to subgroup analysis, in patients with central RVO (CRVO), BCVA improved from 0.82\u00b10.23 to 0.49\u00b10.12 in the effective group and from 0.80\u00b10.18 to 0.76\u00b10.22 in the ineffective group (P&lt;0.001). The CMT changes followed a similar pattern. In patients with branch RVO (BRVO), comparable trends in BCVA and CMT changes were observed between the effective and ineffective groups (P&lt;0.001). Additionally, the effective group exhibited higher PLR and SII values than the ineffective group (P&lt;0.05). Further CRVO and BRVO subgroups analysis exhibited consistent PLR and SII value trends.\nCONCLUSION: Compared to other inflammatory factors, elevated PLR and SII levels before treatment are better predictors of outcomes in young RVO-ME patients undergoing IVC treatment.<\/jats:p>","DOI":"10.18240\/ijo.2025.03.09","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T07:52:31Z","timestamp":1740037951000},"page":"424-434","source":"Crossref","is-referenced-by-count":1,"title":["Serologic parameters in young patients with retinal vein occlusion treated with anti-vascular endothelial growth factor"],"prefix":"10.18240","volume":"18","author":[{"name":"Department of Ophthalmology, Xinjiang 474 Hospital, Urumchi 830000, Xinjiang Uygur Autonomous Region, China","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Tong","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Juan","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Xinjiang 474 Hospital, Urumchi 830000, Xinjiang Uygur Autonomous Region, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Xinjiang 474 Hospital, Urumchi 830000, Xinjiang Uygur Autonomous Region, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2025\/3\/20250309.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T07:52:42Z","timestamp":1740037962000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20250309&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2025.03.09","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]}}}